scholarly journals Targeted treatment in viral‐associated inflammatory cardiomyopathy

2021 ◽  
Vol 9 (7) ◽  
Author(s):  
Ahmad Amin ◽  
Sepideh Taghavi ◽  
Maryam Chenaghlou ◽  
Elahe Zare ◽  
Monireh Kamali ◽  
...  
Keyword(s):  
Targeted Treatment ◽  
Inflammatory Cardiomyopathy

scholarly journals Targeted treatment in viral associated inflammatory cardiomyopathy

2021 ◽  
Author(s):  
Ahmad Amin ◽  
Sepideh Taghavi ◽  
Maryam Chenaghlou ◽  
Elahe Zare ◽  
Monireh Kamali ◽  
...  
Keyword(s):  
Dilated Cardiomyopathy ◽  
Cardiac Failure ◽  
Antiviral Treatment ◽  
Clinical Status ◽  
Viral Myocarditis ◽  
Targeted Treatment ◽  
Human Herpes ◽  
Inflammatory Cardiomyopathy ◽  
Human Herpes Virus ◽  
Human Herpes Virus 6

Though generally self-limited, viral myocarditis can lead to acute cardiac failure or chronic dilated cardiomyopathy. We describe three cases of human herpes virus 6 (HHV6) associated -myocarditis unresponsive to conventional therapies, with detection of HHV-6 evidences and initiation of antiviral treatment, we observed significant improvement in clinical status of patients.

Surface Modified Nanoparticulate Carriers for the Targeted Treatment of Breast Cancer

2015 ◽  
Vol 8 (1) ◽  
pp. 2698-2714
Author(s):  
Neeraj Mishra ◽  
Tejinder Singh ◽  
Nidhi ◽  
Supandeep Singh Hallan ◽  
Veerpal Kaur
Keyword(s):  
Breast Cancer ◽  
Tumor Targeting ◽  
Lipid Nanoparticles ◽  
Targeted Treatment ◽  
Therapeutic Effects ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Therapeutic Outcomes ◽  
Lipid Nanocarriers ◽  
Surface Modified

Breast cancer left overs one of the greatest common metastasis disease in females. Advanced diagnostic devices and better understanding of tumour biology can extend the better therapeutic outcomes. Nanotechnology is a tool that helps in cancer diagnosis and treatment therapy. Many nanocarriers such as solid lipid nanoparticles, magnetic nanoparticles, nanocrystals, nanogels, nano-lipid nanocarriers, biodegradable nanoparticles, liposomes, and dendrimers are introduced to improve the therapeutic efficacy of antineoplastic agents. Surface modified target drug delivery system has the potential to increase the therapeutic effects and also reduce the cytotoxicity of breast cancer. Different approaches have been explored for treatment of breast cancer. This review describes the recent advances in the development of nanocarriers used for the targeted treatment of breast cancer. It also focuses on etiology, risk factor and conventional therapy of breast cancer. KEYWORDS: Breast Cancer; Nano-carriers; Tumor Targeting; Ligands; Receptor.

Gene Therapy, A Targeted Treatment for Diabetic Nephropathy

2013 ◽  
Vol 20 (30) ◽  
pp. 3774-3784 ◽  
Author(s):  
X. Lin ◽  
L. Tao ◽  
D. Tang
Keyword(s):  
Gene Therapy ◽  
Diabetic Nephropathy ◽  
Targeted Treatment

Development of A Novel System Based on Green Magnetic / Graphene Oxide / Chitosan /Allium Sativum / Quercus / Nanocomposite for Targeted Release of Doxorubicin Anti-Cancer Drug

2020 ◽  
Vol 20 (9) ◽  
pp. 1094-1104 ◽  
Author(s):  
Omid Arjmand ◽  
Mehdi Ardjmand ◽  
Ali M. Amani ◽  
Mohmmad H. Eikani
Keyword(s):  
Graphene Oxide ◽  
Allium Sativum ◽  
Cytotoxicity Assay ◽  
Targeted Treatment ◽  
Cancer Drug ◽  
Magnetic Graphene Oxide ◽  
Magnetic Graphene ◽  
Anti Cancer ◽  
Cancerous Cells ◽  
Targeted Release

Background: Doxorubicin, as a strong anti-cancer agent for clinical treatment of various cancer types along with other drugs, is widely utilized. Due to the physiology of the human body and cancerous tissues, the applicability of doxorubicin is still limited and the targeted treatment of the different types of cancers is considered. Also, the side effects of the conventional forms of chemotherapy medicines, damaging and stressing the normal cells are considerable. Objective: This study introduces a novel and effective system for the targeted release of doxorubicin by successfully fabricating the green magnetic graphene oxide, chitosan, allium sativum, and quercus nanocomposite. Methods: The in vitro release of doxorubicin loaded on the nanocomposite was evaluated and investigated at pH 7.4 and 6.5, respectively. The drug diffusivity in the plasma environment was assessed for a more accurate analysis of the drug diffusion process. The nanocomposite loaded drug release mechanism and kinetics, as well as cytotoxicity assay was investigated. Results: The efficiency of the drug encapsulation was significantly enhanced using natural extract ingredients and consequently, the efficacy of the targeted treatment of cancerous tissues was improved. The developed nanocomposite provided a controlled release of doxorubicin in similar acidic conditions of the normal and cancerous cells and affirming that the fabricated system is thoroughly pH-dependent. Conclusion: The cytotoxicity assay confirmed that the fabricated nanocomposite at a high growth rate of cancerous cells has an anticancer property and acts as a toxic agent against tumor cells, suggesting that in conjunction with doxorubicin, it can be highly improved for killing cancerous cells.

scholarly journals Discovery of a rare GKAP1-NTRK2 fusion in a pediatric low-grade glioma, leading to targeted treatment with TRK-inhibitor larotrectinib

2021 ◽  
Vol 22 (3) ◽  
pp. 184-195
Author(s):  
Lily Deland ◽  
Simon Keane ◽  
Thomas Olsson Bontell ◽  
Helene Sjögren ◽  
Henrik Fagman ◽  
...  
Keyword(s):  
Low Grade Glioma ◽  
Targeted Treatment ◽  
Low Grade

scholarly journals The potential role of plasma miR‐155 and miR‐206 as circulatory biomarkers in inflammatory cardiomyopathy

2021 ◽  
Author(s):  
Danilo Obradovic ◽  
Karl‐Philipp Rommel ◽  
Stephan Blazek ◽  
Karin Klingel ◽  
Matthias Gutberlet ◽  
...  
Keyword(s):  
Potential Role ◽  
Inflammatory Cardiomyopathy
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