Hybrid Mesoporous Silica Nanoparticles with pH-Operated and Complementary H-Bonding Caps as an Autonomous Drug-Delivery System

2014 ◽  
Vol 20 (30) ◽  
pp. 9372-9380 ◽  
Author(s):  
Christophe Théron ◽  
Audrey Gallud ◽  
Carole Carcel ◽  
Magali Gary-Bobo ◽  
Marie Maynadier ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles

Wetting transition in nanochannels for biomimetic free-blocking on-demand drug transport

2018 ◽  
Vol 6 (39) ◽  
pp. 6269-6277 ◽  
Author(s):  
Yaya Cheng ◽  
Xiangyu Jiao ◽  
Liang Zhao ◽  
Yang Liu ◽  
Fang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Mesoporous Silica Nanoparticles ◽  
Wetting Transition ◽  
On Demand ◽  
Inner Surface

Inspired by aquaporins in nature, herein, a biomimetic free-blocking on-demand drug delivery system is proposed, which is constructed by controlling the wettability of the inner surface of nanochannels on mesoporous silica nanoparticles (MSNs).

scholarly journals ADAM9-Responsive Mesoporous Silica Nanoparticles for Targeted Drug Delivery in Pancreatic Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3321
Author(s):  
Etienne J. Slapak ◽  
Lily Kong ◽  
Mouad el Mandili ◽  
Rienk Nieuwland ◽  
Alexander Kros ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Conditioned Medium ◽  
Drug Delivery System ◽  
Delivery System ◽  
Targeted Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Pdac Cell ◽  
Targeted Drug

Pancreatic ductal adenocarcinoma (PDAC) has the worst survival rate of all cancers. This poor prognosis results from the lack of efficient systemic treatment regimens, demanding high-dose chemotherapy that causes severe side effects. To overcome dose-dependent toxicities, we explored the efficacy of targeted drug delivery using a protease-dependent drug-release system. To this end, we developed a PDAC-specific drug delivery system based on mesoporous silica nanoparticles (MSN) functionalized with an avidin–biotin gatekeeper system containing a protease linker that is specifically cleaved by tumor cells. Bioinformatic analysis identified ADAM9 as a PDAC-enriched protease, and PDAC cell-derived conditioned medium efficiently cleaved protease linkers containing ADAM9 substrates. Cleavage was PDAC specific as conditioned medium from leukocytes was unable to cleave the ADAM9 substrate. Protease linker-functionalized MSNs were efficiently capped with avidin, and cap removal was confirmed to occur in the presence of PDAC cell-derived ADAM9. Subsequent treatment of PDAC cells in vitro with paclitaxel-loaded MSNs indeed showed high cytotoxicity, whereas no cell death was observed in white blood cell-derived cell lines, confirming efficacy of the nanoparticle-mediated drug delivery system. Taken together, this research introduces a novel ADAM9-responsive, protease-dependent, drug delivery system for PDAC as a promising tool to reduce the cytotoxicity of systemic chemotherapy.

Heat shock responsive drug delivery system based on mesoporous silica nanoparticles coated with temperature sensitive gatekeeper

2017 ◽  
Vol 253 ◽  
pp. 96-101 ◽  
Author(s):  
In-Hye Cho ◽  
Man Kyu Shim ◽  
Bom Jung ◽  
Eun Hyang Jang ◽  
Min-Ju Park ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Heat Shock ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Temperature Sensitive

Mesoporous silica nanoparticles: a promising multifunctional drug delivery system

2017 ◽  
pp. 593-621 ◽  
Author(s):  
Priti P. Pednekar ◽  
Shilpa C. Godiyal ◽  
Kisan R. Jadhav ◽  
Vilasrao J. Kadam
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles

Poly(amidoamine)-modified mesoporous silica nanoparticles as a mucoadhesive drug delivery system for potential bladder cancer therapy

2020 ◽  
Vol 189 ◽  
pp. 110832 ◽  
Author(s):  
Beilei Wang ◽  
Kebiao Zhang ◽  
Jiadong Wang ◽  
Ruibo Zhao ◽  
Quan Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Bladder Cancer ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles

An anticancer drug delivery system based on surfactant-templated mesoporous silica nanoparticles

Biomaterials ◽  
2010 ◽  
Vol 31 (12) ◽  
pp. 3335-3346 ◽  
Author(s):  
Qianjun He ◽  
Jianlin Shi ◽  
Feng Chen ◽  
Min Zhu ◽  
Lingxia Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Anticancer Drug ◽  
Delivery System ◽  
Mesoporous Silica Nanoparticles ◽  
Anticancer Drug Delivery

scholarly journals Evaluation of anti-inflammatory activity and biocompatibility of curcumin loaded mesoporous silica nanoparticles as an oral drug delivery system

2018 ◽  
Vol 9 (3) ◽  
pp. 035007 ◽  
Author(s):  
Lannie Hadisoewignyo ◽  
Sandy Budi Hartono ◽  
Angelica Kresnamurti ◽  
Ivonne Soeliono ◽  
Yolenta Nataline ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Inflammatory Activity ◽  
Oral Drug ◽  
Oral Drug Delivery System
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