scholarly journals MnAl Layered Double Hydroxide Nanoparticles as a Dual-Functional Platform for Magnetic Resonance Imaging and siRNA Delivery

2017 ◽  
Vol 23 (57) ◽  
pp. 14299-14306 ◽  
Author(s):  
Huali Zuo ◽  
Weiyu Chen ◽  
Bei Li ◽  
Kewei Xu ◽  
Helen Cooper ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Layered Double Hydroxide ◽  
Sirna Delivery ◽  
Resonance Imaging ◽  
Dual Functional ◽  
Double Hydroxide ◽  
Layered Double Hydroxide Nanoparticles

scholarly journals Effect of Gd and Dy Concentrations in Layered Double Hydroxides on Contrast in Magnetic Resonance Imaging

Processes ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 462 ◽  
Author(s):  
Karina Nava Andrade ◽  
Gregorio Guadalupe Carbajal Arízaga ◽  
José Antonio Rivera Mayorga
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Mri Contrast Agents ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Molar Ratios ◽  
Magnetic Resonance Imaging Mri ◽  
Double Hydroxide ◽  
Double Hydroxides

In this work, we explore the synthesis of layered double hydroxide (LDH) particles containing different molar ratios of Gd3+ and Dy3+ cations. A single crystalline phase was obtained for Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH, and their efficiency as contrast agents was evaluated by T1- and T2-weighted magnetic resonance imaging (MRI). Both GdDy-LDHs exhibited longitudinal relaxivity (r1) higher than a commercial reference. The highest contrast in the T1 mode was achieved with the Zn2.0Al0.75Gd0.125Dy0.125-LDH, which contained the lowest concentration of lanthanides; this efficiency is related to the lowest amount of carbonate anions complexing the lanthanide sites. On the contrary, the best contrast in the T2 mode was achieved with Zn2.0Al0.5Gd0.25Dy0.25-LDH. Zn2.0Al0.75Gd0.125Dy0.125-LDH and Zn2.0Al0.5Gd0.25Dy0.25-LDH presented r2/r1 ratios of 7.9 and 22.5, respectively, indicating that the inclusion of gadolinium and dysprosium into layered structures is a promising approach to the development of efficient bimodal (T1/T2) MRI contrast agents.

Gadolinium-containing polymer microspheres: a dual-functional theranostic agent for magnetic resonance imaging and cancer therapy

2019 ◽  
Vol 43 (15) ◽  
pp. 5987-5995 ◽  
Author(s):  
Xu Dong ◽  
Muhammad Ali Tahir ◽  
Liwu Zhang ◽  
Christian G. Schäfer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Drug Loading ◽  
Cancer Drug ◽  
Resonance Imaging ◽  
Mri Contrast ◽  
Theranostic Agent ◽  
Dual Functional ◽  
Acid Copolymer ◽  
Anti Cancer

Preparation of poly(gadolinium methacrylate-co-methacrylic acid) copolymer microspheres with high MRI contrast efficiency and controlled anti-cancer drug loading and release capability.

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