Abstract
Context
Pancreatic steatosis may contribute to β-cell dysfunction in type 2 diabetes (T2D), but data are controversial. Women who had gestational diabetes mellitus (GDM) are at high risk for developing T2D.
Objective
To examine the association of pancreatic fat content with early/first-phase insulin secretion (as markers of β-cell function).
Design
Cross-sectional analysis of a subcohort of the monocentric, prospective cohort study titled Prediction, Prevention, and Subclassification of Type 2 Diabetes.
Setting
Ludwig Maximilians University Hospital, Munich, Germany.
Participants
Ninety-seven women, 3 to 16 months after pregnancy [41 normoglycemic women post-GDM, 19 women post-GDM with pathological glucose metabolism, and 37 normoglycemic women after a normoglycemic pregnancy (controls)].
Main Outcome Measures
Correlation of MRI-measured pancreatic fat content with early insulin release in an oral glucose tolerance test (OGGT) [insulin increment within the first 30 minutes of the OGTT (IR30)] and first-phase insulin response (FPIR) in an intravenous glucose tolerance test (n = 65), both adjusted for insulin sensitivity index (ISI).
Results
Pancreatic fat content did not correlate with IR30 and FPIR adjusted for ISI. It correlated positively with body mass index, waist circumference, liver fat, and intraabdominal fat volume.
Conclusion
Pancreatic fat content does not correlate with β-cell function in a cohort of young women with different degrees of T2D risk.
Comparing the effects of 6 months aerobic exercise and resistance training on metabolic control and β‐cell function in Chinese patients with prediabetes: A multicenter randomized controlled trial
