Effects of high-dose vitamin E supplementation on oxidative stress and microalbuminuria in young adult patients with childhood onset type 1 diabetes mellitus

2007 ◽  
Vol 23 (7) ◽  
pp. 539-546 ◽  
Author(s):  
C. Giannini ◽  
F. Lombardo ◽  
F. Currò ◽  
M. Pomilio ◽  
T. Bucciarelli ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Vitamin E ◽  
Young Adult ◽  
High Dose ◽  
Childhood Onset ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes

Diabetes Care ◽  
1999 ◽  
Vol 22 (8) ◽  
pp. 1245-1251 ◽  
Author(s):  
S. E. Bursell ◽  
A. C. Clermont ◽  
L. P. Aiello ◽  
L. M. Aiello ◽  
D. K. Schlossman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Type 1 Diabetes ◽  
Vitamin E ◽  
Creatinine Clearance ◽  
Retinal Blood Flow ◽  
High Dose ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

Evaluation of the effect of oxidative stress and vitamin E supplementation on renal function in rats with streptozotocin-induced Type 1 diabetes

2009 ◽  
Vol 23 (2) ◽  
pp. 130-136 ◽  
Author(s):  
Mohamed A. Haidara ◽  
Dimitri P. Mikhailidis ◽  
Moshira A. Rateb ◽  
Zeinab A. Ahmed ◽  
Hanaa Z. Yassin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Renal Function ◽  
Vitamin E ◽  
Vitamin E Supplementation

Lower dietary n-6 : n-3 ratio and high-dose vitamin E supplementation improve sperm morphology and oxidative stress in boars

2017 ◽  
Vol 29 (5) ◽  
pp. 940 ◽  
Author(s):  
Qing Liu ◽  
Yuanfei Zhou ◽  
Runjia Duan ◽  
Hongkui Wei ◽  
Siwen Jiang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Antioxidant Capacity ◽  
Sperm Morphology ◽  
Tocopherol Content ◽  
High Dose ◽  
Beneficial Effects ◽  
And Oxidative Stress ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

A 2 × 2 factorial experiment (10 boars per treatment) was conducted for 16 weeks to evaluate the effects of the dietary n-6 : n-3 ratio (14 : 1 vs 6 : 1) and vitamin E (200 vs 400 mg kg–1) on boar sperm morphology and oxidative stress. Sperm mitochondrial membrane potential (MMP), reactive oxygen species (ROS), DNA damage (8-hydroxydeoxyguanosine; 8-OHdG), seminal lipoperoxidation (malondialdehyde; MDA) and antioxidant capacity in the serum, spermatozoa and seminal plasma were assessed as indicators of oxidative stress. Sperm production was similar among groups but increased (P < 0.05) throughout the 16 weeks of the study. Although sperm α-tocopherol content, ROS and seminal MDA did not differ between the two dietary n-6 : n-3 ratio treatments, enhanced antioxidant enzyme activity and MMP, but decreased 8-OHdG, were found in spermatozoa from boars consuming the 6 : 1 diet. The diet with the 6 : 1 ratio positively affected sperm morphology at Weeks 12 and 16 (P < 0.05). The α-tocopherol content and antioxidant capacity increased in boars with increasing levels of vitamin E supplementation. Compared with low-dose vitamin E, high-dose vitamin E supplementation improved sperm morphology. Overall, the results indicate that an n-6 : n-3 ratio of 6 : 1 and 400 mg/kg vitamin E have beneficial effects on sperm morphology by improving antioxidative stress.

scholarly journals Long-Term Pharmacologic Doses of Vitamin E Only Moderately Affect the Erythrocytes of Patients with Type 1 Diabetes Mellitus

2001 ◽  
Vol 131 (6) ◽  
pp. 1723-1730 ◽  
Author(s):  
Begoña Manuel y Keenoy ◽  
Honglei Shen ◽  
Wendy Engelen ◽  
Jan Vertommen ◽  
Guido Van Dessel ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Vitamin E ◽  
Type 1 Diabetes Mellitus

Birthweight is not a risk factor for childhood onset Type 1 diabetes mellitus

2000 ◽  
Vol 17 (7) ◽  
pp. 552-552 ◽  
Author(s):  
E. Stenhouse ◽  
H. X. Zhao ◽  
B A. Millward
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Risk Factor ◽  
Type 1 Diabetes Mellitus ◽  
Childhood Onset ◽  
Onset Type

scholarly journals Prevalence of pulmonary tuberculosis in young adult patients with Type 1 diabetes mellitus in India

2016 ◽  
Vol 11 (1) ◽  
Author(s):  
Abilash Nair ◽  
Randeep Guleria ◽  
Devasenathipathy Kandasamy ◽  
Raju Sharma ◽  
Nikhil Tandon ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Young Adult ◽  
Pulmonary Tuberculosis ◽  
Type 1 Diabetes Mellitus ◽  
Adult Patients

scholarly journals Serum Metabolomic Response to Low and High Dose Vitamin E Supplementation in Two Randomized Controlled Trials

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1810-1810
Author(s):  
Jiaqi Huang ◽  
Stephanie Weinstein ◽  
Wendy Mack ◽  
Howard Hodis ◽  
Demetrius Albanes
Keyword(s):  
Prostate Cancer ◽  
Vitamin E ◽  
Cancer Prevention ◽  
Low Dose ◽  
Alpha Tocopherol ◽  
P Value ◽  
High Dose ◽  
Atbc Study ◽  
High Dose Vitamin ◽  
Vitamin E Supplementation

Abstract Objectives Vitamin E is an essential micronutrient and critical human antioxidant that has been tested for cancer and cardiovascular preventative effects for decades with conflicting results. For example, prostate cancer incidence was reduced by a low-dose vitamin E supplement in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study, but the findings were not replicated by high-dose vitamin E trials such as the Selenium and Vitamin E Cancer Prevention Trial (SELECT). The present investigation examined the serum metabolomic responses to low- and high-dose vitamin E supplementation in order to gain biological insight into the divergent trial outcomes. Methods We examined baseline and on-study serum samples for 154 men randomly assigned to receive 400 IU vitamin E (as alpha-tocopheryl acetate; ATA) or placebo daily in the Vitamin E Atherosclerosis Prevention Study (VEAPS), and 100 men administered 50 IU ATA or placebo daily in the ATBC Study. Over 970 known metabolites were identified using an ultrahigh-performance LC-MS/MS platform. Linear regression models estimated the change in serum metabolites of men supplemented with vitamin E to those assigned to placebo in VEAPS compared with ATBC. Results Serum alpha-carboxyethyl hydrochroman (CEHC) sulfate, alpha-tocopherol, and beta-/gamma-tocopherol were significantly altered by supplementation with ATA in both the VEAPS and ATBC trials (all P-values ≤ 5.1 × 10−5, the Bonferroni multiple-comparisons corrected statistical threshold). Serum C22 lactone sulfate was also significantly decreased in response to the high-dose vitamin E supplement in VEAPS (β = −0.70, P-value = 8.1 × 10−6), but not altered in the low-dose ATBC trial (β = −0.17, P-value = 0.4). Additionally, changes in several androgenic steroid metabolites were strongly related to the vitamin E supplement-associated change in C22 lactone sulfate only in the high-dose VEAPS trial. Conclusions We found evidence of a dose-dependent vitamin E supplementation effect on a novel C22 lactone sulfate compound as well as several androgenic steroids that may have relevance to previous controlled trial findings for prostate cancer. Funding Sources This research was supported by the Intramural Research Program of the National Cancer Institute, National Institutes of Health, U.S. Public Health Service, Department of Health and Human Services.

Sign in / Sign up

Export Citation Format

Share Document