scholarly journals A meta‐analysis of amino acid δ 15 N trophic enrichment factors in fishes relative to nutritional and ecological drivers

Ecosphere ◽  
2021 ◽  
Vol 12 (6) ◽  
Author(s):  
M. Teresa Nuche‐Pascual ◽  
Rocío I. Ruiz‐Cooley ◽  
Sharon Z. Herzka
Keyword(s):  
Amino Acid ◽  
Meta Analysis ◽  
Enrichment Factors ◽  
Trophic Enrichment

scholarly journals Amino acid-specific δ15N trophic enrichment factors in fish fed with formulated diets varying in protein quantity and quality

2018 ◽  
Vol 8 (18) ◽  
pp. 9192-9217 ◽  
Author(s):  
M. Teresa Nuche-Pascual ◽  
Juan Pablo Lazo ◽  
Rocío I. Ruiz-Cooley ◽  
Sharon Z. Herzka
Keyword(s):  
Amino Acid ◽  
Enrichment Factors ◽  
Formulated Diets ◽  
Trophic Enrichment

Amino acid 15N trophic enrichment factors of four large carnivorous fishes

2014 ◽  
Vol 453 ◽  
pp. 76-83 ◽  
Author(s):  
Danielle K. Hoen ◽  
Sora L. Kim ◽  
Nigel E. Hussey ◽  
Natalie J. Wallsgrove ◽  
Jeffrey C. Drazen ◽  
...  
Keyword(s):  
Amino Acid ◽  
Enrichment Factors ◽  
Trophic Enrichment

1505 Influence of essential amino acid balancing postpartum on lactation performance by dairy cows through a meta-analysis

2016 ◽  
Vol 94 (suppl_5) ◽  
pp. 730-731
Author(s):  
L. F. Ferraretto ◽  
C. S. Ballard ◽  
C. J. Sniffen ◽  
I. Shinzato
Keyword(s):  
Amino Acid ◽  
Dairy Cows ◽  
Essential Amino Acid ◽  
Meta Analysis ◽  
Lactation Performance

Branched-chain amino acid supplementation and exercise-induced muscle damage in exercise recovery: A meta-analysis of randomized clinical trials

Nutrition ◽  
2017 ◽  
Vol 42 ◽  
pp. 30-36 ◽  
Author(s):  
Mohammad Hossein Rahimi ◽  
Sakineh Shab-Bidar ◽  
Mehdi Mollahosseini ◽  
Kurosh Djafarian
Keyword(s):  
Clinical Trials ◽  
Amino Acid ◽  
Muscle Damage ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Amino Acid Supplementation ◽  
Exercise Recovery ◽  
Branched Chain Amino Acid ◽  
Branched Chain ◽  
Exercise Induced

A systematic meta-analysis of the association of Neuregulin 1 (NRG1), d-amino acid oxidase (DAO), and DAO activator (DAOA)/G72 polymorphisms with schizophrenia

2017 ◽  
Vol 125 (1) ◽  
pp. 89-102 ◽  
Author(s):  
Vinita Jagannath ◽  
Miriam Gerstenberg ◽  
Christoph U. Correll ◽  
Susanne Walitza ◽  
Edna Grünblatt
Keyword(s):  
Amino Acid ◽  
Meta Analysis ◽  
Acid Oxidase ◽  
Amino Acid Oxidase ◽  
Neuregulin 1

scholarly journals Identifying Potential Drug Targets for Sickle Cell Disease through Gene Expression and Pathway Analysis of GEO Data

Blood ◽  
2020 ◽  
Vol 136 (Supplement 1) ◽  
pp. 15-16
Author(s):  
Sharjeel Syed ◽  
Jihad Aljabban ◽  
Jonathan Trujillo ◽  
Saad Syed ◽  
Robert Cameron ◽  
...  
Keyword(s):  
Gene Expression ◽  
Amino Acid ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Drug Targets ◽  
Meta Analysis ◽  
Cell Disease ◽  
Blood Samples ◽  
Disease Modifying Therapies ◽  
Disease Modifying

Background: The pathogenesis of sickle cell disease (SCD) and its complications have been well characterized down to the molecular level. However, there remains a relative dearth of disease modifying therapies that reduce the frequency and number of vas-occlusive crises, hospitalizations, and deaths. Recent advancements in utilizing hydroxyurea and L-glutamine, which both impact unique disease pathways, should pave way for the identification of other molecular pathways as ideal drug targets. In this regard, our meta-analysis serves to identify key genes and associated pathways that are differentially expressed in SC patients. Methods: We employed our STARGEO platform to tag samples from the NCBI Gene Expression Omnibus and performed meta-analysis to compare SC and healthy control transcriptomes. For the meta-analysis, we tagged 285 peripheral blood samples from SC patients and 86 samples from healthy subjects as a control. We then analyzed the signature in Ingenuity Pathway Analysis to elucidate top disease functions from our analysis. Results: From our meta-analysis, we identified iron homeostasis signaling, NRF2-mediated oxidative stress response, cell senescence, and pyrimidine interconversion/biosynthesis as top canonical pathways that were upregulated in the peripheral blood samples from SC patients. Top upstream regulators included membrane associated protein and transporter ABCB6, non-coding RNY3, and erythroid maturation transcription factors GATA1, KLF1, and HIPK2 (with predicted activation). The most upregulated genes included inflammatory modulators RNF182 and IFI27, the latter of which has been shown to inhibit vascular endothelial growth and repair. Several membrane-associated protein coding genes such as GYPA, RAP1GAP, and PAQR9 were also upregulated in the SC samples. RAP1GAP is known to modulate neutrophil cell adhesion and homing while PAQR9 has roles in regulating protein quality control: a role also seen in similarly upregulated YOD1, a deubiquitinating enzyme involved in trafficking of misfolded proteins. Expectedly, also upregulated were HBBP1 and SOX6, which regulate globin genes and have been shown to silence γ-globin expression. Lastly, SLC6A19, the neutral amino acid transporter mutated in Hartnup disease, was also upregulated. Of the downregulated genes, WASF3, a member of the Wiskott-Aldrich syndrome protein family, has been linked to poor survival in many malignancies, including AML and CMML, but has not previously been linked to SCD pathogenesis. ENKUR was also downregulated and has been annotated as a tethering protein to cation channels as well as linked to pathways involving vascular leakage. SIGLEC10, which binds to vascular adhesion proteins, is a key suppressor of inflammatory responses to damage; it's downregulation along with ELAPOR1, a transmembrane protein involved in cellular response to stress, was also observed. Finally, based off the focus genes in our analysis we identified several networks with most being involved in amino acid metabolism, cellular assembly, function, and maintenance, hematological disease, and organismal injury. The top pathway is illustrated in Figure 1. Conclusions: Our study illustrates differentially expressed gene activity in SCD consistent with known pathophysiology such as immune response, endothelial damage and adherence, heme metabolism, and globin regulation. We also showed evidence of genes not previously studied in SCD, which may have novel roles such as those part of the ubiquitin-proteasome system like YOD1 and RNF182. Additionally, while some genes in our analysis like EKLF and GAT1 have been shown to enhance δ-globin expression, paving way for possible drug therapies for B-hemoglobinopathies, others like IFI27, PAQR9, RAP1GAP, ENKUR, SIGLEC10, WASF3, and SOX9 have yet to be studied as mediators of disease pathogenesis in SCD. A target to SOX9, a known suppressor of γ-globin, or ABCB6, a known modulator of erythroid cell shape and hydration, have particularly promising potential as disease modifying therapies. Finally, HIPK2, HBBP1, and SLC6A19 have previously been shown to have intriguing effects on hydroxyurea dosing and responsivity in SC patients and may also be candidate target molecules to enhance existing therapies. These data identify potential candidate pathways for mechanistic studies seeking to confirm a causative role in the pathogenesis of sickle cell disease. Disclosures No relevant conflicts of interest to declare.

Effect of phytase on amino acid digestibility in pig: A meta-analysis

2018 ◽  
Vol 238 ◽  
pp. 18-28 ◽  
Author(s):  
M. Zouaoui ◽  
M.P. Létourneau-Montminy ◽  
F. Guay
Keyword(s):  
Amino Acid ◽  
Meta Analysis

scholarly journals Expanded Spectrum of Antiretroviral-Selected Mutations in Human Immunodeficiency Virus Type 2

2020 ◽  
Vol 221 (12) ◽  
pp. 1962-1972 ◽  
Author(s):  
Philip L Tzou ◽  
Diane Descamps ◽  
Soo-Yon Rhee ◽  
Dana N Raugi ◽  
Charlotte Charpentier ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Amino Acid ◽  
Meta Analysis ◽  
Multiple Comparisons ◽  
Resistance Mutations ◽  
Drug Resistance Mutations ◽  
Immunodeficiency Virus ◽  
Hiv 1

Abstract Background HIV-1 and HIV-2 differ in their antiretroviral (ARV) susceptibilities and drug resistance mutations (DRMs). Methods We analyzed published HIV-2 pol sequences to identify HIV-2 treatment-selected mutations (TSMs). Mutation prevalences were determined by HIV-2 group and ARV status. Nonpolymorphic mutations were those in <1% of ARV-naive persons. TSMs were those associated with ARV therapy after multiple comparisons adjustment. Results We analyzed protease (PR) sequences from 483 PR inhibitor (PI)-naive and 232 PI-treated persons; RT sequences from 333 nucleoside RT inhibitor (NRTI)-naive and 252 NRTI-treated persons; and integrase (IN) sequences from 236 IN inhibitor (INSTI)-naive and 60 INSTI-treated persons. In PR, 12 nonpolymorphic TSMs occurred in ≥11 persons: V33I, K45R, V47A, I50V, I54M, T56V, V62A, A73G, I82F, I84V, F85L, L90M. In RT, 9 nonpolymorphic TSMs occurred in ≥10 persons: K40R, A62V, K70R, Y115F, Q151M, M184VI, S215Y. In IN, 11 nonpolymorphic TSMs occurred in ≥4 persons: Q91R, E92AQ, T97A, G140S, Y143G, Q148R, A153G, N155H, H156R, R231 5-amino acid insertions. Nine of 32 nonpolymorphic TSMs were previously unreported. Conclusions This meta-analysis confirmed the ARV association of previously reported HIV-2 DRMs and identified novel TSMs. Genotypic and phenotypic studies of HIV-2 TSMs will improve approaches to predicting HIV-2 ARV susceptibility and treating HIV-2–infected persons.

scholarly journals Insights into the structure and function of HV1 from a meta-analysis of mutation studies

2016 ◽  
Vol 148 (2) ◽  
pp. 97-118 ◽  
Author(s):  
Thomas E. DeCoursey ◽  
Deri Morgan ◽  
Boris Musset ◽  
Vladimir V. Cherny
Keyword(s):  
Amino Acid ◽  
Ion Channel ◽  
Meta Analysis ◽  
Structure And Function ◽  
Proton Channel ◽  
Vast Array ◽  
Voltage Gated ◽  
Interspecies Differences ◽  
And Function ◽  
Sheer Number

The voltage-gated proton channel (HV1) is a widely distributed, proton-specific ion channel with unique properties. Since 2006, when genes for HV1 were identified, a vast array of mutations have been generated and characterized. Accessing this potentially useful resource is hindered, however, by the sheer number of mutations and interspecies differences in amino acid numbering. This review organizes all existing information in a logical manner to allow swift identification of studies that have characterized any particular mutation. Although much can be gained from this meta-analysis, important questions about the inner workings of HV1 await future revelation.

Meta-analysis of amino acid stable nitrogen isotope ratios for estimating trophic position in marine organisms

Oecologia ◽  
2015 ◽  
Vol 178 (3) ◽  
pp. 631-642 ◽  
Author(s):  
Jens M. Nielsen ◽  
Brian N. Popp ◽  
Monika Winder
Keyword(s):  
Amino Acid ◽  
Trophic Position ◽  
Meta Analysis ◽  
Nitrogen Isotope ◽  
Isotope Ratios ◽  
Marine Organisms ◽  
Stable Nitrogen Isotope ◽  
Acid Stable
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