Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridization

2005 ◽  
Vol 42 (3) ◽  
pp. 247-259 ◽  
Author(s):  
Kylie L. Gorringe ◽  
Alex Boussioutas ◽  
David D. L. Bowtell ◽  
◽  
Keyword(s):  
Gastric Cancer ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization

scholarly journals Cancer Comprehensive Analysis in Gastric Carcinoma: Benefits and New Perspectives

2021 ◽  
pp. 1682-1690
Author(s):  
Vasiliki Pisanidou ◽  
Panagiotis Apostolou ◽  
Georgios Beis ◽  
Eleana Hatzidaki ◽  
Ioannis Papasotiriou
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Tumor Cells ◽  
Circulating Tumor Cells ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Screening Tools ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Efficient Treatment

Gastric cancer is one of the most common and deadly cancers worldwide. Screening tests as well as tools for prediction of treatment outcomes and prognosis have been developed, but they have many limitations. The integration of liquid biopsy provided new aspects in screening and diagnosis of gastric cancer. In the present study, we used different techniques, studying the genetic and epigenetic profile of circulating tumor cells. We aimed to acquire all the available information, compare it with already existing studies, and evaluate the benefit of this approach. A blood sample was isolated from 2 gastric cancer patients at stages III–IV, followed by the isolation of CTCs. The circulating tumor cells were used for array comparative genomic hybridization, next-generation sequencing, and whole gene expression microarrays. Different variants were detected, while the microsatellite instability status was stable in both cases. The tumor mutational burden was low to medium. Gene expression assays revealed that >100 genes were overexpressed compared to noncancer samples. Amplifications of X chromosome were also observed in both cases, by using array comparative genomic hybridization. Although there are several techniques for cancer screening, prediction of therapy outcomes, and prognosis, the application of a complete comprehensive cancer panel, combining the study of variants, fusions, chromosomal abnormalities, and gene expression, is more appropriate. Information provided by the above techniques might contribute in designing more efficient treatment protocols and screening tools. Despite the limitation of samples, the data are encouraging, and further study is needed so that they can be used at clinical level.

The clinical utility of molecular karyotyping using high-resolution array-comparative genomic hybridization

2012 ◽  
Vol 12 (5) ◽  
pp. 449-457 ◽  
Author(s):  
Maria Tzetis ◽  
Sofia Kitsiou-Tzeli ◽  
Helen Frysira ◽  
Athena Xaidara ◽  
Emmanuel Kanavakis
Keyword(s):  
High Resolution ◽  
Comparative Genomic Hybridization ◽  
Clinical Utility ◽  
Array Comparative Genomic Hybridization ◽  
Molecular Karyotyping ◽  
Comparative Genomic ◽  
Genomic Hybridization

Metaphase and array comparative genomic hybridization: unique copy number changes and gene amplification of medulloblastomas in South America

2006 ◽  
Vol 170 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Maisa Yoshimoto ◽  
Jane Bayani ◽  
Paulo A.S. Nuin ◽  
Nasjla S. Silva ◽  
Sergio Cavalheiro ◽  
...  
Keyword(s):  
South America ◽  
Comparative Genomic Hybridization ◽  
Gene Amplification ◽  
Copy Number ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Copy Number Changes

Immortalization of epithelial cells in oral carcinogenesis as revealed by genome-wide array comparative genomic hybridization: A meta-analysis

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E783-E797
Author(s):  
Vui King Vincent-Chong ◽  
Iman Salahshourifar ◽  
Rozaimi Razali ◽  
Arif Anwar ◽  
Rosnah Binti Zain
Keyword(s):  
Epithelial Cells ◽  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Meta Analysis ◽  
Comparative Genomic ◽  
Genomic Hybridization ◽  
Oral Carcinogenesis ◽  
Genome Wide

Homozygous deletions of cadherin genes in chondrosarcoma—an array comparative genomic hybridization study

2012 ◽  
Vol 205 (11) ◽  
pp. 588-593 ◽  
Author(s):  
Tarja Niini ◽  
Ilari Scheinin ◽  
Leo Lahti ◽  
Suvi Savola ◽  
Fredrik Mertens ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Array Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Hybridization Study ◽  
Genomic Hybridization ◽  
Homozygous Deletions
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