The effects of the dopamine and serotonin transporter polymorphisms on clinical features and treatment response in geriatric depression: a pilot study

2007 ◽  
Vol 23 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Helen Lavretsky ◽  
Prabha Siddarth ◽  
Anand Kumar ◽  
Charles F. Reynolds
Keyword(s):  
Pilot Study ◽  
Treatment Response ◽  
Clinical Features ◽  
Serotonin Transporter ◽  
Geriatric Depression

scholarly journals Regional White Matter Integrity Predicts Treatment Response to Escitalopram and Memantine in Geriatric Depression: A Pilot Study

2020 ◽  
Vol 11 ◽  
Author(s):  
Beatrix Krause-Sorio ◽  
Prabha Siddarth ◽  
Michaela M. Milillo ◽  
Roza Vlasova ◽  
Linda Ercoli ◽  
...  
Keyword(s):  
White Matter ◽  
Pilot Study ◽  
Treatment Response ◽  
White Matter Integrity ◽  
Geriatric Depression

P.309 Late-life depression: How do patients with early-onset vs late-onset differ in clinical features and treatment response?

2020 ◽  
Vol 31 ◽  
pp. S52-S53
Author(s):  
W.R. Chae ◽  
M. Fuentes Casan ◽  
F. Gutknecht ◽  
A. Ljubez ◽  
S.M. Gold ◽  
...  
Keyword(s):  
Treatment Response ◽  
Clinical Features ◽  
Early Onset ◽  
Late Onset ◽  
Late Life ◽  
Late Life Depression

scholarly journals The Influence of Genetics in Myopia Control: A Pilot Study

2021 ◽  
Vol 10 (4) ◽  
pp. 808
Author(s):  
Cristina Alvarez-Peregrina ◽  
Miguel Ángel Sánchez-Tena ◽  
Clara Martinez-Perez ◽  
Catalina Santiago-Dorrego ◽  
Thomas Yvert ◽  
...  
Keyword(s):  
Pilot Study ◽  
Treatment Response ◽  
Axial Length ◽  
Contact Lenses ◽  
Control Method ◽  
Saliva Sample ◽  
Experimental Studies ◽  
Strong Linkage Disequilibrium ◽  
Student’S T ◽  
Myopia Control

Background: Many epidemiological and experimental studies have established that myopia is caused by a complex interaction between common genetic and environmental factors. The objective of this study was to describe and compare the allelic and genotypic frequencies of the rs524952 (GJD2), rs8000973 (ZIC2), rs1881492 (CHRNG), rs1656404 (PRSS56), rs235770 (BMP2), and rs7744813 (KCNQ5) SNPs (single-nucleotide polymorphism) between responder and nonresponder patients who had undergone a two-year treatment with lenses for myopia control. Method: Twenty-eight participants from the MiSight Assessment Study Spain (MASS), who had received treatment for myopia control for two years with MiSight contact lenses, were examined. The criteria for better/worse treatment response was the change in the axial length (< / ≥ 0.22 mm two years after the treatment). The clinical procedure consisted of the extraction of a saliva sample, and the participants also underwent an optometric examination. Genetic data were analyzed using SNPStats software (Catalan Institute of Oncology, Barcelona, Spain), and statistical analysis was performed using SPSS v.25 (SPSS Inc., Chicago, IL, USA). Demographic variables were analyzed using the Student’s t-test. Results: The T allele, the one with the lowest frequency, of the “rs235770” SNP was associated with a better treatment response [AL/CR (axial length/corneal radius): OR = 3.37; CI = 1.079–10.886; SE (spherical equivalent): OR = 1.26; CI: = 0.519–57.169; p = 0.019). By performing haplotype analysis, significant differences were found between the rs235770…rs1881492 and rs235770–rs1656404 polymorphisms. The latter presented a strong linkage disequilibrium with each other (r2 ≥ 0.54). Conclusion: The result of lens therapies for myopia control could vary depending on genetic variants. Studies with a larger sample are needed to confirm the results presented in this pilot study.

Default mode network connectivity and treatment response in geriatric depression

2021 ◽  
Vol 29 (4) ◽  
pp. S104-S105
Author(s):  
Lisa Kilpatrick ◽  
Beatrix Krause-Sorio ◽  
Prabha Siddarth ◽  
Katherine Narr ◽  
Helen Lavretsky
Keyword(s):  
Treatment Response ◽  
Default Mode Network ◽  
Network Connectivity ◽  
Geriatric Depression ◽  
Default Mode

Allelic Differences in the Serotonin Transporter-Linked Polymorphic Region in Geriatric Depression

2002 ◽  
Vol 10 (2) ◽  
pp. 185-191 ◽  
Author(s):  
David C. Steffens ◽  
Ingrid Svenson ◽  
Douglas A. Marchuk ◽  
Robert M. Levy ◽  
Judith C. Hays ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Geriatric Depression ◽  
Polymorphic Region ◽  
Allelic Differences

Selective genotyping for the role of 5-HT2A, 5-HT2C, and GABAα6 receptors and the serotonin transporter in the level of response to alcohol: a pilot study

1999 ◽  
Vol 45 (5) ◽  
pp. 647-651 ◽  
Author(s):  
Marc A Schuckit ◽  
Chiara Mazzanti ◽  
Tom L Smith ◽  
Umbereen Ahmed ◽  
Marta Radel ◽  
...  
Keyword(s):  
Pilot Study ◽  
Serotonin Transporter ◽  
Selective Genotyping

A Pilot Study of Antidepressant-Induced Mania in Pediatric Bipolar Disorder: Characteristics, Risk Factors, and the Serotonin Transporter Gene

2006 ◽  
Vol 60 (9) ◽  
pp. 1005-1012 ◽  
Author(s):  
Fiona M. Baumer ◽  
Meghan Howe ◽  
Kim Gallelli ◽  
Diana Iorgova Simeonova ◽  
Joachim Hallmayer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Pilot Study ◽  
Serotonin Transporter ◽  
Serotonin Transporter Gene ◽  
Pediatric Bipolar Disorder ◽  
Transporter Gene

scholarly journals Clinical Features of Familial or Hereditary Prostate Cancer in Korean Men: A Pilot Study

2011 ◽  
Vol 52 (1) ◽  
pp. 9 ◽  
Author(s):  
Seung Hwan Lee ◽  
Kyung Kgi Park ◽  
Mun Su Chung ◽  
Byung Ha Chung
Keyword(s):  
Prostate Cancer ◽  
Pilot Study ◽  
Clinical Features ◽  
Hereditary Prostate Cancer
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