Association of age and gender with anxiety disorders in older adults: A systematic review and meta‐analysis

AbstractSeveral comorbidities have been shown to be associated with coronavirus disease 2019 (COVID-19) related severity and mortality. However, considerable variation in the prevalence estimates of comorbidities and their effects on COVID-19 morbidity and mortality have been observed in prior studies. This systematic review and meta-analysis aimed to determine geographical, age, and gender related differences in the prevalence of comorbidities and associated severity and mortality rates among COVID-19 patients. We conducted a search using PubMed, Scopus, and EMBASE to include all COVID-19 studies published between January 1st, 2020 to July 24th, 2020 reporting comorbidities with severity or mortality. We included studies reporting the confirmed diagnosis of COVID-19 on human patients that also provided information on comorbidities or disease outcomes. We used DerSimonian and Laird random effects method for calculating estimates. Of 120 studies with 125,446 patients, the most prevalent comorbidity was hypertension (32%), obesity (25%), diabetes (18%), and cardiovascular disease (16%) while chronic kidney or other renal diseases (51%, 44%), cerebrovascular accident (43%, 44%), and cardiovascular disease (44%, 40%) patients had more COVID-19 severity and mortality respectively. Considerable variation in the prevalence of comorbidities and associated disease severity and mortality in different geographic regions was observed. The highest mortality was observed in studies with Latin American and European patients with any medical condition, mostly older adults (≥ 65 years), and predominantly male patients. Although the US studies observed the highest prevalence of comorbidities in COVID-19 patients, the severity of COVID-19 among each comorbid condition was highest in Asian studies whereas the mortality was highest in the European and Latin American countries. Risk stratification and effective control strategies for the COVID-19 should be done according to comorbidities, age, and gender differences specific to geographical location.

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Age- and gender-specific prevalence of depression in latest-life – Systematic review and meta-analysis

Journal of Affective Disorders ◽

10.1016/j.jad.2010.11.033 ◽

2012 ◽

Vol 136 (3) ◽

pp. 212-221 ◽

Cited By ~ 335

Author(s):

M. Luppa ◽

C. Sikorski ◽

T. Luck ◽

L. Ehreke ◽

A. Konnopka ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Age And Gender ◽

Prevalence Of Depression ◽

And Gender ◽

Gender Specific

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TRENDS IN THE PREVALENCE OF FRAILTY IN JAPAN: A META-ANALYSIS FROM THE ILSA-J

Journal of Frailty & Aging ◽

10.14283/jfa.2020.68 ◽

2020 ◽

pp. 1-8

Author(s):

H. MAKIZAKO ◽

Y. NISHITA ◽

S. JEONG ◽

R. OTSUKA ◽

H. SHIMADA ◽

...

Keyword(s):

Older Adults ◽

Weight Loss ◽

Meta Analysis ◽

Physical Frailty ◽

Age And Gender ◽

Frailty Status ◽

Japanese Cohort ◽

And Gender ◽

Meta Analyses ◽

Low Activity

Objective: To examine whether age-specific prevalence of frailty in Japan changed between 2012 and 2017. Design: This study performed meta-analyses of data collected from 2012 to 2017 using the Integrated Longitudinal Studies on Aging in Japan (ILSA-J), a collection of representative Japanese cohort studies. Setting: The ILSA-J studies were conducted on community-living older adults. Participants: ILSA-J studies were considered eligible for analysis if they assessed physical frailty status and presence of frailty in the sample. Seven studies were analyzed for 2012 (±1 year; n = 10312) and eight studies were analyzed for 2017 (±1 year; n = 7010). Five studies were analyzed for both 2012 and 2017. Measurements: The study assessed the prevalence of frailty and frailty status according to 5 criteria: slowness, weakness, low activity, exhaustion, and weight loss.Results: The overall prevalence of physical frailty was 7.0% in 2012 and 5.3% in 2017. The prevalence of frailty, especially in people 70 years and older, tended to decrease in 2017 compared to 2012. Slight decreases were found in the prevalence of frailty subitems including weight loss, slowness, exhaustion, and low activity between 2012 and 2017, but change in the prevalence of weakness was weaker than other components. Conclusions: The prevalence of physical frailty decreased from 2012 to 2017. There are age- and gender-related variations in the decrease of each component of frailty.

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Efficacy and effectiveness of psychological interventions on co‐occurring mood and anxiety disorders in older adults: A systematic review and meta‐analysis

International Journal of Geriatric Psychiatry ◽

10.1002/gps.5486 ◽

2021 ◽

Author(s):

Viviana M. Wuthrich ◽

Denise Meuldijk ◽

Tess Jagiello ◽

Alberto González Robles ◽

Michael P. Jones ◽

...

Keyword(s):

Systematic Review ◽

Older Adults ◽

Anxiety Disorders ◽

Meta Analysis ◽

Psychological Interventions ◽

Mood And Anxiety Disorders

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Therapeutic efficacy of denosumab for rheumatoid arthritis: a systematic review and meta-analysis

Rheumatology Advances in Practice ◽

10.1093/rap/rkab099 ◽

2021 ◽

Author(s):

Mayu Yagita ◽

Takayoshi Morita ◽

Atsushi Kumanogoh

Keyword(s):

Rheumatoid Arthritis ◽

Systematic Review ◽

Bone Resorption ◽

Disease Activity ◽

Therapeutic Efficacy ◽

Meta Analysis ◽

Mineral Density ◽

Age And Gender ◽

And Gender ◽

Denosumab Treatment

Abstract Objectives Denosumab is used for osteoporosis, as it inhibits osteoclast maturation and suppresses bone resorption. Although denosumab is expected to inhibit the bone erosion in rheumatoid arthritis (RA), its therapeutic efficacy is not well established. The aim of this study was to estimate the effects of denosumab on RA through a meta-analysis. Methods A systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. PubMed, Web of Science and Scopus were searched for original studies providing information on bone mineral density (BMD), joint destruction and disease activity in denosumab-treated RA. A random-effects model was used in the meta-analysis. Results Of the 367 studies identified, 18 met the selection criteria. The BMDs of the lumbar spine, total hip and femoral neck at 12 months after denosumab treatment increased by 5.27% (95% confidence interval: 4.37–6.18), 2.82% (2.46–3.18) and 3.07% (2.66–3.48), respectively. In the sensitivity analysis, age and gender tended to influence the effect of denosumab therapy on the variation rate of BMD, but not glucocorticoid use. The changes in the modified total sharp, erosion and joint space narrowing scores at 12 months after denosumab treatment were significantly smaller with denosumab than with placebo, although the disease activity score did not change after denosumab treatment. Conclusion Although denosumab has an inhibitory effect on the bone resorption in RA, its effects may be influenced by age and gender of RA, but not glucocorticoid use.

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Is swimming in recreational water associated with the occurrence of respiratory illness? A systematic review and meta-analysis

Journal of Water and Health ◽

10.2166/wh.2016.266 ◽

2016 ◽

Vol 14 (4) ◽

pp. 590-599 ◽

Cited By ~ 4

Author(s):

Alice Mannocci ◽

Giuseppe La Torre ◽

Alessandro Spagnoli ◽

Angelo G. Solimini ◽

Caterina Palazzo ◽

...

Keyword(s):

Systematic Review ◽

Meta Analysis ◽

Respiratory Illness ◽

Water Quality Monitoring ◽

Polluted Water ◽

Monitoring Systems ◽

Significant Heterogeneity ◽

Recreational Water ◽

Age And Gender ◽

And Gender

This study represents the first systematic review and meta-analysis conducted to assess the association between swimming in recreational water and the occurrence of respiratory illness. Most studies focus their attention on gastrointestinal illnesses occurring after exposure to microbial polluted water. Fourteen independent studies that included 50,117 patients with significant heterogeneity (I2 = 95.3%) were reviewed. The meta-analysis reports that people exposed to recreational water (swimmers/bathers) present a higher risk of respiratory illness compared to non-swimmers/non-bathers [relative risk (RR) = 1.63 (confidence interval at 95% [95% CI]: 1.34–1.98)]. This percentage increases if adjusted RR by age and gender [RR = 2.24 (95% CI: 1.81–2.78)] are considered. A clear association between swimming in recreational water and the occurrence of respiratory illness was found. The surveillance of water quality monitoring systems is crucial not only for gastrointestinal illness, but also for respiratory ones.

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