Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia-1

Head & Neck ◽  
2015 ◽  
Vol 38 (S1) ◽  
pp. E761-E770 ◽  
Author(s):  
Haeng-Eun Lee ◽  
Jeong-Seok Nam ◽  
Ji-Ae Shin ◽  
In-Sun Hong ◽  
In-Hyoung Yang ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cancer Treatment ◽  
Myeloid Cell ◽  
Salivary Gland Cancer ◽  
Cell Leukemia ◽  
Therapeutic Alternative ◽  
Novel Therapeutic

From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)

2019 ◽  
Author(s):  
James Papatzimas ◽  
Evgueni Gorobets ◽  
Ranjan Maity ◽  
Mir Ishruna Muniyat ◽  
Justin L. MacCallum ◽  
...  
Keyword(s):  
Small Molecules ◽  
E3 Ligase ◽  
Myeloid Cell ◽  
Cell Leukemia ◽  
New Class ◽  
Apoptotic Protein ◽  
Family Protein ◽  
Ubiquitination Pathway

<div> <div> <div> <p>Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family protein degraders. </p> </div> </div> </div>

Systemic Therapy for Salivary Gland Cancer

2021 ◽  
pp. 455-469
Author(s):  
Janakiraman Subramanian ◽  
Lara Kujtan
Keyword(s):  
Salivary Gland ◽  
Systemic Therapy ◽  
Salivary Gland Cancer

scholarly journals Exposure‐toxicity relationship of cabozantinib in patients with renal cell cancer and salivary gland cancer

2021 ◽  
Author(s):  
Stefanie D. Krens ◽  
Wim Boxtel ◽  
Maike J. M. Uijen ◽  
Frank G. A. Jansman ◽  
Ingrid M. E. Desar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Renal Cell Cancer ◽  
Renal Cell ◽  
Cell Cancer ◽  
Salivary Gland Cancer ◽  
Relationship Of ◽  
Toxicity Relationship

scholarly journals Heterogeneous impact of smoking on major salivary gland cancer according to histopathological subtype: A case-control study

Cancer ◽  
2017 ◽  
Vol 124 (1) ◽  
pp. 118-124 ◽  
Author(s):  
Michi Sawabe ◽  
Hidemi Ito ◽  
Taishi Takahara ◽  
Isao Oze ◽  
Daisuke Kawakita ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Case Control Study ◽  
Case Control ◽  
Salivary Gland Cancer ◽  
Major Salivary Gland ◽  
Subtype A ◽  
Histopathological Subtype ◽  
Control Study
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