scholarly journals Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice

Hepatology ◽  
2013 ◽  
Vol 58 (4) ◽  
pp. 1339-1348 ◽  
Author(s):  
Joy X. Jiang ◽  
Xiangling Chen ◽  
Hiroo Fukada ◽  
Nobuko Serizawa ◽  
Sridevi Devaraj ◽  
...  
Keyword(s):  
Enzyme Activity ◽  
Nonalcoholic Steatohepatitis ◽  
Advanced Glycation Endproducts ◽  
Converting Enzyme ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Tnf Α

Effects of plant-derived polyphenols on TNF-α and nitric oxide production induced by advanced glycation endproducts

2010 ◽  
Vol 54 (S2) ◽  
pp. S141-S150 ◽  
Author(s):  
Dave Chandler ◽  
Ameha Woldu ◽  
Anton Rahmadi ◽  
Kirubakaran Shanmugam ◽  
Nicole Steiner ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Advanced Glycation Endproducts ◽  
Nitric Oxide Production ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Oxide Production ◽  
Tnf Α

scholarly journals The Immune Tolerance Role of the HMGB1-RAGE Axis

Cells ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 564
Author(s):  
Haruki Watanabe ◽  
Myoungsun Son
Keyword(s):  
Immune Responses ◽  
Immune Tolerance ◽  
Lupus Erythematosus ◽  
Advanced Glycation Endproducts ◽  
High Mobility ◽  
Chromatin Binding ◽  
Advanced Glycation ◽  
Glycation Endproducts ◽  
Extracellular Milieu

The disruption of the immune tolerance induces autoimmunity such as systemic lupus erythematosus and vasculitis. A chromatin-binding non-histone protein, high mobility group box 1 (HMGB1), is released from the nucleus to the extracellular milieu in particular environments such as autoimmunity, sepsis and hypoxia. Extracellular HMGB1 engages pattern recognition receptors, including Toll-like receptors (TLRs) and the receptor for advanced glycation endproducts (RAGE). While the HMGB1-RAGE axis drives inflammation in various diseases, recent studies also focus on the anti-inflammatory effects of HMGB1 and RAGE. This review discusses current perspectives on HMGB1 and RAGE’s roles in controlling inflammation and immune tolerance. We also suggest how RAGE heterodimers responding microenvironments functions in immune responses.

scholarly journals Pomelo fruit wastes are potentially valuable antioxidants, anti-inflammatories, antihypertensives, and antihyperglycemics

2021 ◽  
Author(s):  
Li-Yun Lin ◽  
Chi-Yun Huang ◽  
Kuan-Chou Chen ◽  
Robert Y. Peng
Keyword(s):  
Enzyme Activity ◽  
Hepg2 Cells ◽  
Protocatechuic Acid ◽  
Converting Enzyme ◽  
Coumaric Acid ◽  
Angiotensin Converting Enzyme Activity ◽  
Tnf Α ◽  
Ethanolic Extracts ◽  
Fruit Wastes ◽  
Considerable Loss

AbstractGrapefruit (G) parts contain abundant phenolic acids and flavonoids (PPNs and FLVs). The wastes created from exocarps, mesocarps (G wastes, GW) and waste blanching water (WBW) lead to a considerable loss of PPNs and FLVs. Here, we assessed Buntan (CB), Buntan Hayata (CBH), and Peiyu (CP) cultivars and observed considerable amounts of PPNs and FLVs. The ethanolic extracts of GW (GWE) and WBW contained gallic acid, protocatechuic acid, chlorogenic acid, caffeic acid, ferulic acid, coumaric acid, naringin, hesperidin, diosmin, quercetin, hesperetin, nobiletin, and tangeretin (GWC). GWE has previously been reported to be a relatively active antioxidant, anti-inflammatory (based on the expression of TNF-α in Raw264.7 cells), antihypertensive, and anti-hyperglycemic compound. The IC50 values for antihyperglycemic activity with WBW for α-amylase were as follows: CB (27.96 ± 0.03 mg/mL) < CP (28.13 ± 0.19 mg/mL) < CBH (41.60 ± 0.16 mg/mL), and those for α-glucosidase were CB (1.80 ± 0.03 mg/mL) < CP (2.97 ± 0.29 mg/mL) < CBH (9.10 ± 0.51 mg/mL). GWC upregulated Glut4 in HepG2 cells, as well as the insulin secretion capability, and intracellular levels in RIN-m5F cells, and it downregulated DPP4 in HepG2 cells. The IC50 values for the angiotensin-converting enzyme activity were: CBP (5.10 ± 0.02 mg/mL) < CB (7.24 ± 0.65 mg/mL) < CP (8.60 ± 2.03 mg/mL). Our results indicate that PPNs and FLVs present in GW are worth reclaiming.

scholarly journals Is skin autofluorescence (SAF) representative of dermal advanced glycation endproducts (AGEs) in dark skin? A pilot study

Heliyon ◽  
2020 ◽  
Vol 6 (11) ◽  
pp. e05364
Author(s):  
Isabella M. Atzeni ◽  
Jeltje Boersema ◽  
Hendri H. Pas ◽  
Gilles F.H. Diercks ◽  
Jean L.J.M. Scheijen ◽  
...  
Keyword(s):  
Pilot Study ◽  
Advanced Glycation Endproducts ◽  
Skin Autofluorescence ◽  
Advanced Glycation ◽  
Dark Skin ◽  
Glycation Endproducts

scholarly journals Receptor for advanced glycation endproducts (RAGE) maintains pulmonary structure and regulates the response to cigarette smoke

PLoS ONE ◽  
2017 ◽  
Vol 12 (7) ◽  
pp. e0180092 ◽  
Author(s):  
Lisa Wolf ◽  
Christian Herr ◽  
Julia Niederstraßer ◽  
Christoph Beisswenger ◽  
Robert Bals
Keyword(s):  
Cigarette Smoke ◽  
Advanced Glycation Endproducts ◽  
Advanced Glycation ◽  
Glycation Endproducts
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