Letter to the Editor: Appraisal of Cardiac Ejection Fraction With Liver Disease Severity

Abstract. Some epidemiological evidence suggests an inverse correlation between non-alcoholic fatty liver disease (NAFLD) frequency and vitamin D levels. Likewise, a beneficial effect of vitamin D on diabetes mellitus (DM) and insulin resistance has been observed, but this is an unsolved issue. Thus, we aimed to investigate the prevalence of hypovitaminosis D in a NAFLD Brazilian population and its association with disease severity and presence of comorbidities. In a cross-sectional study, the clinical, biochemical and histological parameters of 139 NAFLD patients were evaluated according to two different cut-off points of serum 25-hydroxyvitamin D levels (20 ng/mL and 30 ng/mL). The mean age of the population was 56 ± 16 years, most patients were female (83%), 72% had hypertension, 88% dyslipidemia, 46% DM, 98% central obesity, and 82% metabolic syndrome. Serum vitamin D levels were < 30 ng/mL in 78% of the patients, and < 20 ng/mL in 35%. The mean vitamin D level was 24.3 ± 6.8 ng/mL. The comparison between the clinical, biochemical and histological characteristics of the patients according to the levels of vitamin D showed no significant difference. Most patients with NAFLD had hypovitaminosis D, but low vitamin D levels were not related to disease severity and the presence of comorbidities.

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Patterns of dendritic cell and monocyte subsets are associated with disease severity and mortality in liver cirrhosis patients

Scientific Reports ◽

10.1038/s41598-021-85148-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Chandra Chiappin Cardoso ◽

Camila Matiollo ◽

Carolina Hilgert Jacobsen Pereira ◽

Janaina Santana Fonseca ◽

Helder Emmanuel Leite Alves ◽

...

Keyword(s):

Dendritic Cells ◽

Liver Cirrhosis ◽

Liver Disease ◽

Dendritic Cell ◽

Disease Severity ◽

Advanced Liver Disease ◽

Hla Dr ◽

Acute Decompensation ◽

Cirrhotic Patients ◽

Classical Monocytes

AbstractLiver cirrhosis is often complicated by an immunological imbalance known as cirrhosis-associated immune dysfunction. This study aimed to investigate disturbances in circulating monocytes and dendritic cells in patients with acute decompensation (AD) of cirrhosis. The sample included 39 adult cirrhotic patients hospitalized for AD, 29 patients with stable cirrhosis (SC), and 30 healthy controls (CTR). Flow cytometry was used to analyze monocyte and dendritic cell subsets in whole blood and quantify cytokines in plasma samples. Cirrhotic groups showed higher frequencies of intermediate monocytes (iMo) than CTR. AD patients had lower percentages of nonclassical monocytes than CTR and SC. Cirrhotic patients had a profound reduction in absolute and relative dendritic cell numbers compared with CTR and showed higher plasmacytoid/classical dendritic cell ratios. Increased plasma levels of IL-6, IL-10, and IL-17A, elevated percentages of CD62L+ monocytes, and reduced HLA-DR expression on classical monocytes (cMo) were also observed in cirrhotic patients. Patients with more advanced liver disease showed increased cMo and reduced tissue macrophages (TiMas) frequencies. It was found that cMo percentages greater than 90.0% within the monocyte compartment and iMo and TiMas percentages lower than 5.7% and 8.6%, respectively, were associated with increased 90-day mortality. Monocytes and dendritic cells are deeply altered in cirrhotic patients, and subset profiles differ between stable and advanced liver disease. High cMo and low TiMas frequencies may be useful biomarkers of disease severity and mortality in liver cirrhosis.

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PMO-178 The significance of viral and serological markers in predicting liver disease severity in e-Ag negative hepatitis b virus infection

Gut ◽

10.1136/gutjnl-2012-302514b.178 ◽

2012 ◽

Vol 61 (Suppl 2) ◽

pp. A146.1-A146

Author(s):

V K Audimoolam ◽

I Carey ◽

M Bruce ◽

M Horner ◽

S Abid ◽

...

Keyword(s):

Liver Disease ◽

Hepatitis B Virus ◽

Virus Infection ◽

Hepatitis B ◽

Disease Severity ◽

Hepatitis B Virus Infection ◽

Serological Markers ◽

B Virus

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Microsatellite polymorphism in the heme oxygenase-1 gene promoter is not associated with alcoholic liver disease severity

Hepatology ◽

10.1002/hep.26534 ◽

2013 ◽

Vol 59 (1) ◽

pp. 352-353 ◽

Cited By ~ 1

Author(s):

Anne Lemaire ◽

Eric Trépo ◽

Romy Ouziel ◽

Thierry Gustot ◽

Christophe Moreno ◽

...

Keyword(s):

Liver Disease ◽

Disease Severity ◽

Heme Oxygenase ◽

Alcoholic Liver Disease ◽

Gene Promoter ◽

Microsatellite Polymorphism ◽

Heme Oxygenase 1

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Stroke in Heart Failure in Sinus Rhythm: The Warfarin versus Aspirin in Reduced Cardiac Ejection Fraction Trial

Cerebrovascular Diseases ◽

10.1159/000352058 ◽

2013 ◽

Vol 36 (1) ◽

pp. 74-78 ◽

Cited By ~ 4

Author(s):

Patrick M. Pullicino ◽

John L.P. Thompson ◽

Ralph L. Sacco ◽

Alexandra R. Sanford ◽

Min Qian ◽

...

Keyword(s):

Heart Failure ◽

Ejection Fraction ◽

Sinus Rhythm ◽

Cardiac Ejection Fraction

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Letter to the Editor: Liver stiffness by transient elastography to detect porto‐sinusoidal vascular liver disease

Hepatology ◽

10.1002/hep.31867 ◽

2021 ◽

Author(s):

Lianqing Lou ◽

Xiaofei Li

Keyword(s):

Liver Disease ◽

Transient Elastography ◽

Liver Stiffness ◽

Letter To The Editor

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Abstract 14793: Association Between Cardiac Ejection Fraction and the Size of Stroke

Circulation ◽

10.1161/circ.142.suppl_3.14793 ◽

2020 ◽

Vol 142 (Suppl_3) ◽

Author(s):

Muhammad M Alvi ◽

Tamra Ranasinghe ◽

Yasser Kabbani ◽

Mohamad Adnan Alkhouli ◽

Abdul Rahman Tarabishy

Keyword(s):

Atrial Fibrillation ◽

Ejection Fraction ◽

Thrombus Formation ◽

Infarct Volume ◽

Inverse Correlation ◽

Stroke Patients ◽

Increased Risk ◽

Median Volume ◽

Cardiac Ejection Fraction ◽

Low Ejection Fraction

Introduction: Heart failure with low ejection fraction (EF) is a known risk factor for stroke. Low EF is associated with increased risk of thrombus formation and is accompanied with 2 to 3 fold increased risk of stroke. This can happen even in the absence of atrial fibrillation. Hypothesis: Our hypothesis was that size of the stroke will be larger in patients with reduction in EF as compared with cardioembolic strokes in preserved EF. The worse the EF, the more stagnation of blood and poor cardiac output leading higher risk of thrombus formation. It’s also likely that the group with reduced EF form a larger thrombus leading to larger stroke as compared to the group with preserved EF. Methods: For our analysis, we retrospectively reviewed charts for 49 acute ischemic stroke patients without atrial fibrillation. We used transthoracic echocardiogram to determine the EF. There are 25 patients with preserved EF, cutoff > 50%. There were 24 patients in reduced EF group. Both groups were matched for age and cardiovascular risk factors. Infarct volume was manually calculated from T1 MRI using BrainLab software. Results: There is an inverse correlation between EF and infarct volume (r=-.283, p=.048) meaning patients with reduced EF had greater infarct volume. Median infarct volume is higher in reduced EF group (median volume = 36 cm 3 ) compared to patients with preserved EF (median volume = 11 cm 3 ) (p=.117). Conclusions: In our patient’s sample, there seems to be an inverse correlation between EF and size of stroke. Patients with reduced EF were associated with larger strokes. Larger studies need to be performed to establish a correlation.

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