Metabolomic Analysis Uncovers Energy Supply Disturbance as an Underlying Mechanism of the Development of Alcohol‐Associated Liver Cirrhosis

Fuzheng-Huayu (FZHY) tablet was formulated based on Chinese medicine theory in treating liver fibrosis. A clinical trial has indicated that FZHY can against hepatitis B-caused liver cirrhosis (HBC), but the underlying mechanism of FZHY efficacy is unclear. Here, we report that miRNA expression levels are remarkably changed when FZHY formula was used in HBC patient’s treatment as a paradigm of trials. Then, we functionally characterize the significant impact of potential kernel miRNAs by miRNA-target network analysis. Enrichment analysis show that the FZHY formula dramatically effecting the molecular regulated module in HBC. Thus, we infer that FZHY plays a critical function in HBC treatment process and directly regulated many important pathways, including but not limited to cell cycle, p53 signaling pathway, and TGF-βsignaling pathway, suggesting a new strategy for investigating the molecular mechanism of FZHY treatment.

Download Full-text

Stevia Prevents Acute and Chronic Liver Injury Induced by Carbon Tetrachloride by Blocking Oxidative Stress through Nrf2 Upregulation

Oxidative Medicine and Cellular Longevity ◽

10.1155/2018/3823426 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 21

Author(s):

Erika Ramos-Tovar ◽

Erika Hernández-Aquino ◽

Sael Casas-Grajales ◽

Laura D. Buendia-Montaño ◽

Silvia Galindo-Gómez ◽

...

Keyword(s):

Oxidative Stress ◽

Liver Cirrhosis ◽

Carbon Tetrachloride ◽

Liver Damage ◽

Underlying Mechanism ◽

Chronic Liver ◽

Chronic Liver Damage ◽

Experimental Cirrhosis ◽

Male Wistar Rats ◽

First Time

The effect of stevia on liver cirrhosis has not been previously investigated. In the present study, the antioxidant and anti-inflammatory properties of stevia leaves were studied in male Wistar rats with carbon tetrachloride- (CCl4-) induced acute and chronic liver damage. Acute and chronic liver damage induced oxidative stress, necrosis, and cholestasis, which were significantly ameliorated by stevia. Chronic CCl4 treatment resulted in liver cirrhosis, as evidenced by nodules of hepatocytes surrounded by thick bands of collagen and distortion of the hepatic architecture, and stevia significantly prevented these alterations. Subsequently, the underlying mechanism of action of the plant was analyzed. Our study for the first time shows that stevia upregulated Nrf2, thereby counteracting oxidative stress, and prevented necrosis and cholestasis through modulation of the main proinflammatory cytokines via NF-κB inhibition. These multitarget mechanisms led to the prevention of experimental cirrhosis. Given the reasonable safety profile of stevia, our results indicated that it may be useful for the clinical treatment of acute and chronic liver diseases.

Download Full-text

Comparative metabolomic analysis reveals global cadmium stress response ofLactobacillus plantarumstrains

Metallomics ◽

10.1039/c8mt00095f ◽

2018 ◽

Vol 10 (8) ◽

pp. 1065-1077 ◽

Cited By ~ 5

Author(s):

Qixiao Zhai ◽

Yue Xiao ◽

Arjan Narbad ◽

Wei Chen

Keyword(s):

Stress Response ◽

Cadmium Stress ◽

Underlying Mechanism ◽

Metabolomic Analysis ◽

Cd Tolerance

The underlying mechanism of strain-specific differences ofL. plantarumin terms of cadmium (Cd) tolerance was elucidated, and some key metabolite biomarkers were annotated.

Download Full-text

Redox Reactions in Lipid Membranes as a Model for Primordial Energy-Conserving Systems

International Astronomical Union Colloquium ◽

10.1017/s0252921100014950 ◽

1997 ◽

Vol 161 ◽

pp. 437-442

Author(s):

Salvatore Di Bernardo ◽

Romana Fato ◽

Giorgio Lenaz

Keyword(s):

Experimental Evidence ◽

Lipid Membranes ◽

Energy Supply ◽

Redox Reactions ◽

Living Systems ◽

Asymmetric Distribution ◽

Conservation Of Energy ◽

Asymmetrical Distribution ◽

Energy Conserving ◽

Living Organisms

AbstractOne of the peculiar aspects of living systems is the production and conservation of energy. This aspect is provided by specialized organelles, such as the mitochondria and chloroplasts, in developed living organisms. In primordial systems lacking specialized enzymatic complexes the energy supply was probably bound to the generation and maintenance of an asymmetric distribution of charged molecules in compartmentalized systems. On the basis of experimental evidence, we suggest that lipophilic quinones were involved in the generation of this asymmetrical distribution of charges through vectorial redox reactions across lipid membranes.

Download Full-text

Cognitive components in liver cirrhosis patients

Electroencephalography and Clinical Neurophysiology ◽

10.1016/s0013-4694(97)88684-5 ◽

1997 ◽

Vol 103 (1) ◽

pp. 149 ◽

Cited By ~ 1

Author(s):

V Mateeva

Keyword(s):

Liver Cirrhosis ◽

Cognitive Components

Download Full-text

Renal hyporfusion, glomerular vas efferens vasocostriction and loss of tubular-glomerular freedback in patients with decompensated non-azotemic liver cirrhosis

Gastroenterology ◽

10.1016/s0016-5085(01)81873-4 ◽

2001 ◽

Vol 120 (5) ◽

pp. A377-A377

Author(s):

G SANSOE ◽

A BIAVAAUSTEFANOSILVANO ◽

F ROSINA ◽

A TOUSCOZ ◽

A SMEDILE ◽

...

Keyword(s):

Liver Cirrhosis

Download Full-text

The effect of liver cirrhosis on body composition in a Brazilian sample

Gastroenterology ◽

10.1016/s0016-5085(01)81299-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A262-A262

Author(s):

F FIGUEIREDO ◽

M KONDO ◽

M CHARLTON

Keyword(s):

Body Composition ◽

Liver Cirrhosis ◽

Brazilian Sample

Download Full-text

Small intestinal motillity disturbances and bacterial overgrowth in patients with liver cirrhosis is associated with portal hypertension

Gastroenterology ◽

10.1016/s0016-5085(01)81115-x ◽

2001 ◽

Vol 120 (5) ◽

pp. A224-A224

Author(s):

A GUNNARSDOTTIR ◽

E BJOMSSON ◽

G RINGSTROM ◽

M SIMREN ◽

P STOTZER ◽

...

Keyword(s):

Liver Cirrhosis ◽

Portal Hypertension ◽

Bacterial Overgrowth ◽

Small Intestinal

Download Full-text

The Gastric Mucosa in Liver Cirrhosis

Gastroenterology ◽

10.1016/s0016-5085(19)35909-8 ◽

1956 ◽

Vol 31 (1) ◽

pp. 74-78 ◽

Cited By ~ 4

Author(s):

Angelo E. Dagradi ◽

Donald Olson ◽

Stephen Stempien

Keyword(s):

Liver Cirrhosis ◽

Gastric Mucosa

Download Full-text

Face Inversion Effect Emerges Under Critical Configural Discrepancy

Swiss Journal of Psychology ◽

10.1024/1421-0185/a000018 ◽

2010 ◽

Vol 69 (3) ◽

pp. 161-167 ◽

Cited By ~ 3

Author(s):

Jisien Yang ◽

Adrian Schwaninger

Keyword(s):

Face Recognition ◽

Face Processing ◽

Underlying Mechanism ◽

Inversion Effect ◽

Configural Processing ◽

Major Contributor ◽

Face Inversion Effect ◽

Configural Information ◽

Face Inversion ◽

The Face

Configural processing has been considered the major contributor to the face inversion effect (FIE) in face recognition. However, most researchers have only obtained the FIE with one specific ratio of configural alteration. It remains unclear whether the ratio of configural alteration itself can mediate the occurrence of the FIE. We aimed to clarify this issue by manipulating the configural information parametrically using six different ratios, ranging from 4% to 24%. Participants were asked to judge whether a pair of faces were entirely identical or different. The paired faces that were to be compared were presented either simultaneously (Experiment 1) or sequentially (Experiment 2). Both experiments revealed that the FIE was observed only when the ratio of configural alteration was in the intermediate range. These results indicate that even though the FIE has been frequently adopted as an index to examine the underlying mechanism of face processing, the emergence of the FIE is not robust with any configural alteration but dependent on the ratio of configural alteration.

Download Full-text