Mutations and polymorphisms in the human methyl CpG-binding protein MECP2

2003 ◽  
Vol 22 (2) ◽  
pp. 107-115 ◽  
Author(s):  
Gabriel Miltenberger-Miltenyi ◽  
Franco Laccone
Keyword(s):  
Binding Protein ◽  
Protein Mecp2

scholarly journals The Methyl-CpG-binding Protein MeCP2 Links DNA Methylation to Histone Methylation

2002 ◽  
Vol 278 (6) ◽  
pp. 4035-4040 ◽  
Author(s):  
François Fuks ◽  
Paul J. Hurd ◽  
Daniel Wolf ◽  
Xinsheng Nan ◽  
Adrian P. Bird ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Histone Methylation ◽  
Binding Protein ◽  
Protein Mecp2

scholarly journals The methyl-CpG-binding protein MECP2 is required for prostate cancer cell growth

Oncogene ◽  
2005 ◽  
Vol 25 (9) ◽  
pp. 1358-1366 ◽  
Author(s):  
D Bernard ◽  
J Gil ◽  
P Dumont ◽  
S Rizzo ◽  
D Monté ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Binding Protein ◽  
Cancer Cell Growth ◽  
Protein Mecp2

The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in the mouse

1995 ◽  
Vol 6 (8) ◽  
pp. 491-492 ◽  
Author(s):  
D. A. Adler ◽  
N. A. Quaderi ◽  
S. D. M. Brown ◽  
V. M. Chapman ◽  
J. Moore ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
X Inactivation ◽  
Methylated Dna ◽  
Protein Mecp2

The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse

1996 ◽  
Vol 12 (2) ◽  
pp. 205-208 ◽  
Author(s):  
Peri Tate ◽  
William Skarnes ◽  
Adrian Bird
Keyword(s):  
Embryonic Development ◽  
Binding Protein ◽  
Protein Mecp2

miR-212 is downregulated and suppresses methyl-CpG-binding protein MeCP2 in human gastric cancer

2009 ◽  
Vol 127 (5) ◽  
pp. 1106-1114 ◽  
Author(s):  
Rie Wada ◽  
Yoshimitsu Akiyama ◽  
Yutaka Hashimoto ◽  
Hiroshi Fukamachi ◽  
Yasuhito Yuasa
Keyword(s):  
Gastric Cancer ◽  
Binding Protein ◽  
Human Gastric Cancer ◽  
Protein Mecp2

scholarly journals The methyl CpG-binding protein MeCP2 is over-expressed in brain metastatic breast cancer.

2020 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Metastatic Breast Cancer ◽  
Brain Metastases ◽  
Binding Protein ◽  
Metastatic Breast ◽  
Clinical Problem ◽  
Gene Encoding ◽  
Control Of Gene Expression ◽  
The Brain ◽  
Protein Mecp2

Control of gene expression includes regulation by trans-acting transcription factors and cis-acting epigenetic regulation by chemical modification of histones and the DNA (1, 2). Brain metastases are a clinical problem in patients with breast cancer (3-5). We mined published microarray data (6-8) to discover genes associated with brain metastasis in patients with brain metastatic breast cancer. We found that the gene encoding the methyl CpG-binding protein MeCP2, a molecule with critical epigenetic functions in the brain (9, 10), was among the genes most differentially expressed in the brain metastases of patients with brain metastatic breast cancer. MeCP2 may be of relevance to the biology underlying metastasis to the brain, and it may be of relevance as a potential therapeutic target in patients with intractable disease.

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