The association between stressful life events and breast cancer risk: A meta-analysis

2003 ◽  
Vol 107 (6) ◽  
pp. 1023-1029 ◽  
Author(s):  
Saskia F.A. Duijts ◽  
Maurice P.A. Zeegers ◽  
Bart Vd Borne
2019 ◽  
Vol 176 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Narjes Bahri ◽  
Tahereh Fathi Najafi ◽  
Fatemeh Homaei Shandiz ◽  
Hamid Reza Tohidinik ◽  
Abdoljavad Khajavi

2009 ◽  
Vol 25 (suppl 3) ◽  
pp. S453-S463 ◽  
Author(s):  
Míria Conceição Lavinas Santos ◽  
Bernardo Lessa Horta ◽  
João Joaquim Freitas do Amaral ◽  
Paula Frassinetti Castelo Branco Camurça Fernandes ◽  
Cristina Maria Galvão ◽  
...  

The objective of the current meta-analysis was to verify the association between stressful life events and primary breast cancer incidence in women. A total of 618 studies from 1982-2007 were found in the PubMed, LILACS, and Cochrane Library databases. Methodological quality was evaluated according to the Downs & Black criteria. Eight studies were selected (six case-controls and two cohorts). The studies were grouped in three analyses, two of which based on the categories widowhood and divorce and the other based on self-rated intensity and frequency of stressful events. Relative risks were: widowhood 1.04 (95%CI: 0.75-1.44; p = 0.800); divorce 1.03 (95%: 0.72-1.48; p = 0.850); and intensity/frequency of stress 1.73 (95%CI: 0.98-3.05; p = 0.059). We conclude that stressful life events as a whole are not associated with risk of breast cancer in women. However, it is not possible to rule out high-intensity stress as a risk factor for breast cancer.


2020 ◽  
Vol 35 (6) ◽  
pp. 1253-1255
Author(s):  
Zeev Blumenfeld ◽  
Norbert Gleicher ◽  
Eli Y Adashi

Abstract Whereas longstanding dogma has purported that pregnancies protect women from breast cancer, a recent meta-analysis now mandates reconsideration since it reported an actual higher breast cancer risk for more than two decades after childbirth before the relative risk turns negative. Moreover, the risk of breast cancer appears higher for women having their first birth at an older age and with a family history and it is not reduced by breastfeeding. The process of obtaining informed consent for all fertility treatments, therefore, must make patients aware of the facts that every pregnancy, to a small degree, will increase the short-term breast cancer risk. This observation may be even more relevant in cases of surrogacy where women agree to conceive without deriving benefits of offspring from assuming the risk, thus creating a substantially different risk-benefit ratio. Consequently, it appears prudent for professional societies in the field to update recommendations regarding consent information for all fertility treatments but especially for treatments involving surrogacy.


2017 ◽  
Vol 296 (6) ◽  
pp. 1043-1053 ◽  
Author(s):  
Md. Mohaimenul Islam ◽  
Hsuan-Chia Yang ◽  
Phung-Anh Nguyen ◽  
Tahmina Nasrin Poly ◽  
Chih-Wei Huang ◽  
...  

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