scholarly journals Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

2011 ◽  
Vol 128 (9) ◽  
pp. 1999-2009 ◽  
Author(s):  
Pallavi Lonkar ◽  
Peter C. Dedon
Keyword(s):  
Dna Damage ◽  
Chronic Inflammation ◽  
Reactive Species ◽  
Chemical Mechanisms

P108. Nitrative and oxidative DNA damage via chronic inflammation by liver fluke infection; in relation to cholangiocarcinoma development

Nitric Oxide ◽  
2008 ◽  
Vol 19 ◽  
pp. 68
Author(s):  
Mariko Murata ◽  
Yusuke Hiraku ◽  
Shinji Oikawa ◽  
Ning Ma ◽  
Shosuke Kawanishi
Keyword(s):  
Dna Damage ◽  
Chronic Inflammation ◽  
Oxidative Dna Damage ◽  
Liver Fluke ◽  
Fluke Infection ◽  
Liver Fluke Infection

Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis

2006 ◽  
Vol 387 (4) ◽  
pp. 365-372 ◽  
Author(s):  
Shosuke Kawanishi ◽  
Yusuke Hiraku ◽  
Somchai Pinlaor ◽  
Ning Ma
Keyword(s):  
Dna Damage ◽  
Chronic Inflammation ◽  
Inflammatory Diseases ◽  
Inflammatory Cells ◽  
Oral Diseases ◽  
Dna Lesion ◽  
Bowel Diseases ◽  
Antiparasitic Drugs ◽  
Immunofluorescence Labeling ◽  
Oxide Synthase

Abstract Infection and chronic inflammation are proposed to contribute to carcinogenesis through inflammation-related mechanisms. Infection with hepatitis C virus, Helicobacter pylori and the liver fluke, Opisthorchis viverrini (OV), are important risk factors for hepatocellular carcinoma (HCC), gastric cancer and cholangiocarcinoma, respectively. Inflammatory bowel diseases (IBDs) and oral diseases, such as oral lichen planus (OLP) and leukoplakia, are associated with colon carcinogenesis and oral squamous cell carcinoma (OSCC), respectively. We performed a double immunofluorescence labeling study and found that nitrative and oxidative DNA lesion products, 8-nitroguanine and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG), were formed and inducible nitric oxide synthase (iNOS) was expressed in epithelial cells and inflammatory cells at the site of carcinogenesis in humans and animal models. Antibacterial, antiviral and antiparasitic drugs dramatically diminished the formation of these DNA lesion markers and iNOS expression. These results suggest that oxidative and nitrative DNA damage occurs at the sites of carcinogenesis, regardless of etiology. Therefore, it is considered that excessive amounts of reactive nitrogen species produced via iNOS during chronic inflammation may play a key role in carcinogenesis by causing DNA damage. On the basis of our results, we propose that 8-nitroguanine is a promising biomarker to evaluate the potential risk of inflammation-mediated carcinogenesis.

scholarly journals Molecular Analysis of a Multistep Lung Cancer Model Induced by Chronic Inflammation Reveals Epigenetic Regulation of p16, Activation of the DNA Damage Response Pathway

Neoplasia ◽  
2007 ◽  
Vol 9 (10) ◽  
pp. 840-IN12 ◽  
Author(s):  
David Blanco ◽  
Silvestre Vicent ◽  
Mario F. Fraga ◽  
Ignacio Fernandez-Garcia ◽  
Javier Freire ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Dna Damage ◽  
Chronic Inflammation ◽  
Molecular Analysis ◽  
Dna Damage Response ◽  
Epigenetic Regulation ◽  
Cancer Model ◽  
Damage Response ◽  
Lung Cancer Model ◽  
Dna Damage Response Pathway

DNA-damage response associated with occupational exposure, age and chronic inflammation in workers in the automotive industry

2012 ◽  
Vol 748 (1-2) ◽  
pp. 21-28 ◽  
Author(s):  
Natalya V. Savina ◽  
Marharyta P. Smal ◽  
Tatyana D. Kuzhir ◽  
Alla A. Ershova-Pavlova ◽  
Roza I. Goncharova
Keyword(s):  
Dna Damage ◽  
Occupational Exposure ◽  
Chronic Inflammation ◽  
Dna Damage Response ◽  
Automotive Industry ◽  
Exposure Age ◽  
Damage Response

scholarly journals The Methyl Xanthine Caffeine Inhibits DNA Damage Signaling and Reactive Species and Reduces Atherosclerosis in ApoE −/− Mice

2012 ◽  
Vol 32 (10) ◽  
pp. 2461-2467 ◽  
Author(s):  
John R. Mercer ◽  
Kelly Gray ◽  
Nichola Figg ◽  
Sheetal Kumar ◽  
Martin R. Bennett
Keyword(s):  
Dna Damage ◽  
Reactive Species ◽  
Dna Damage Signaling ◽  
Methyl Xanthine

scholarly journals Chronic inflammation-related DNA damage response: a driving force of gastric cardia carcinogenesis

Oncotarget ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2856-2864 ◽  
Author(s):  
Runhua Lin ◽  
Dejun Xiao ◽  
Yi Guo ◽  
Dongping Tian ◽  
Hailong Yun ◽  
...  
Keyword(s):  
Dna Damage ◽  
Chronic Inflammation ◽  
Dna Damage Response ◽  
Driving Force ◽  
Gastric Cardia ◽  
Damage Response
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