Electron microscopic study of virus particles in reproductive organs of mice inoculated with leukemia virus (Moloney)

1968 ◽  
Vol 3 (3) ◽  
pp. 351-363 ◽  
Author(s):  
Harish C. Chopra ◽  
Frederick E. Durr
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Leukemia Virus ◽  
Reproductive Organs ◽  
Electron Microscopic ◽  
Virus Particles

Laryngeal Papilloma: Etiologic and Therapeutic Considerations

1973 ◽  
Vol 82 (5) ◽  
pp. 649-655 ◽  
Author(s):  
Ted A. Cook ◽  
Arnold M. Cohn ◽  
J. Pierre Brunschwig ◽  
Helmuth Goepfert ◽  
Janet S. Butel ◽  
...  
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Surgical Excision ◽  
Therapeutic Trial ◽  
Electron Microscopic ◽  
Virus Particles ◽  
Epidemiologic Factors ◽  
Therapeutic Program ◽  
Complete Surgical Excision ◽  
Tissue Specimens

A study of 13 patients with laryngeal papillomas is presented, with an analysis of epidemiologic factors, electron microscopic study of the lesion, and therapeutic trial of frequent microlaryngoscopic surgery and application of idoxuridine. Five of the nine children in this group were delivered by mothers who had condyloma accuminatum at time of delivery. These five children developed symptoms and required surgery much earlier than the other four. This correlation is shown to be statistically significant. The electron microscopic study of tissue specimens from all our patients failed to find any actual virus particles. The comparison study with skin and genital warts, however, showed ultrastructural details linking the three lesions. Results of the therapeutic program showed an overall improvement in frequency of recurrence, but no complete cures. This improvement is felt to be related to frequent complete surgical excision, and not to application of idoxuridine.

ELECTRON MICROSCOPIC STUDY ON VIRUS PARTICLES IN MAMMARY CARCINOMAS AND IN THEIR TRANSPLANTS AND CULTURED CELLS IN LOW-CANCER STRAIN MICE

Uirusu ◽  
1966 ◽  
Vol 16 (1-2) ◽  
pp. 6-12
Author(s):  
Kiyoshi HIRAKI ◽  
Zensuke OTA ◽  
Isao MIYOSHI ◽  
Hideo HARADA ◽  
Shinya SUZUKI ◽  
...  
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Cultured Cells ◽  
Electron Microscopic ◽  
Mammary Carcinomas ◽  
Virus Particles

Electron Microscopic Study of Viral Particles in the Pancreas of Normal and Leukemic Mice

1972 ◽  
Vol 58 (3) ◽  
pp. 143-156 ◽  
Author(s):  
Gabriella Della Torre
Keyword(s):  
Bone Marrow ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Exocrine Pancreas ◽  
Leukemia Virus ◽  
Quantitative Difference ◽  
Electron Microscopic ◽  
Viral Particles ◽  
Type C ◽  
And Control

An electron microscopic study of viral particles was conducted on pancreas, thymus, and bone marrow of normal and leukemic (C57BL x C3Hf) F1 (BC3) and SWR mice. The leukemic mice had developed thymic lymphosarcoma after neonatal injection of N-nitrosomethylurea or urethan. An intense proliferation of type C particles morphologically identical to the murine leukemia virus was found in the acinar cells of the exocrine pancreas of BC3 mice. The particles were predominantly located in intracytoplasmic vacuoles but they were also numerous in dilated cisternae of the rough endoplasmic reticulum and in extracellular spaces. A substantial quantitative difference of type C particles between the pancreases of leukemic and healthy mice was not observed. No viral particles were found in the pancreas of SWR mice. In the thymus and bone marrow of BC3 and SWR mice a small number of type C particles and intracisternal type A particles was found in all the experimental and control groups. The observation of a high number of type C particles in the exocrine pancreas of BC3 mice is discussed in relation to a viral etiology of chemically-induced lymphomas.

scholarly journals An Electron Microscopic Study of Experimentally-induced HEV Encephalitis

1978 ◽  
Vol 15 (1) ◽  
pp. 102-113 ◽  
Author(s):  
C. Meyvisch ◽  
J. Hoorens
Keyword(s):  
Endoplasmic Reticulum ◽  
Golgi Apparatus ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Mononuclear Cells ◽  
Brain Parenchyma ◽  
Electron Microscopic ◽  
Virus Particles ◽  
Encephalomyelitis Virus ◽  
The Brain

A gnobiotic piglet, was inoculated intracerebrally with hemagglutinating encephalomyelitis virus (strain VW572). Mononuclear cells formed vascular cuffs and were disseminated in the brain parenchyma. A few neurons were surrounded by the same kind of cells. Virus particles morphologically similar to Coronavirus particles were found in the cytoplasm of both chromatolytic light neurons and hyperchromic dark neurons. The particles were in vesicles of distended endoplasmic reticulum and in the hypertrophied Golgi apparatus.

Electron-microscopic study of Herpesvirus macaca in human fibroblasts

1976 ◽  
Vol 22 (1) ◽  
pp. 101-104 ◽  
Author(s):  
Peter R. Graze ◽  
Phillip McGrath ◽  
Glenelle C. Washington ◽  
Ivor Royston
Keyword(s):  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Human Fibroblasts ◽  
Infectious Agent ◽  
Electron Microscopic ◽  
Virus Particles ◽  
Enveloped Virus ◽  
Negative Stain ◽  
Infected Cells ◽  
Myelin Figures

An electron microscopic study of the morphology of Herpesvirus macaca, a serologically distinct infectious agent isolated from the leukocytes of rhesus monkeys, was performed. WI-38 fibroblast monolayers were infected with the virus and examined 18 days later. The morphology of Herpesvirus macaca was, in general, typical of the herpesvirus group. Enveloped virus particles observed via negative-stain technique had a diameter of 145–155 nm. An inner capsid composed of hexagonal capsomeres had a diameter of 100–110 nm and surrounded a central core. While enveloped forms appeared to be present within the nuclei of infected cells, they were not found in the cytoplasm except within vacuolar structures. Associated changes were found in the morphology of infected cells, including intracytoplasmic myelin figures.

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