scholarly journals Tumor-associated mesenchymal stem cells inhibit naïve T cell expansion by blocking cysteine export from dendritic cells

2016 ◽  
Vol 139 (9) ◽  
pp. 2068-2081 ◽  
Author(s):  
Tithi Ghosh ◽  
Subhasis Barik ◽  
Avishek Bhuniya ◽  
Jesmita Dhar ◽  
Shayani Dasgupta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cell Expansion ◽  
T Cell Expansion ◽  
Naïve T Cell ◽  
Naive T Cell

The lymphoid chemokine CCL21 costimulates naïve T cell expansion and Th1 polarization of non-regulatory CD4+ T cells

2004 ◽  
Vol 231 (1-2) ◽  
pp. 75-84 ◽  
Author(s):  
Kenneth Flanagan ◽  
Dorota Moroziewicz ◽  
Heesun Kwak ◽  
Heidi Hörig ◽  
Howard L. Kaufman
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cd4 T Cells ◽  
Cell Expansion ◽  
T Cell Expansion ◽  
Th1 Polarization ◽  
Naïve T Cell ◽  
Naive T Cell

Mast cells and T-cell expansion

Blood ◽  
2008 ◽  
Vol 111 (5) ◽  
pp. 2497-2498
Author(s):  
Susumu Nakae ◽  
Keisuke Oboki ◽  
Hirohisa Saito
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Mast Cells ◽  
Cell Expansion ◽  
Memory T Cells ◽  
T Cell Expansion

IgE/antigen-FcϵRI crosslinking promotes antigen internalization and apoptosis in mouse mast cells. Dendritic cells uptake the apoptotic mast cells carrying internalized antigens, and thus can efficiently present the antigens to memory T cells.

scholarly journals Involvement of Mesenchymal Stem Cells in Oral Mucosal Bacterial Immunotherapy

2020 ◽  
Vol 11 ◽  
Author(s):  
Alberto Vázquez ◽  
Lidia M. Fernández-Sevilla ◽  
Eva Jiménez ◽  
David Pérez-Cabrera ◽  
Rosa Yañez ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Macrophage Polarization ◽  
Differentiation Potential ◽  
Functional Changes ◽  
T Lymphocyte Proliferation ◽  
Tract Infections

Recent clinical observations indicate that bacterial vaccines induce cross-protection against infections produced by different microorganisms. MV130, a polyvalent bacterial sublingual preparation designed to prevent recurrent respiratory infectious diseases, reduces the infection rate in patients with recurrent respiratory tract infections. On the other hand, mesenchymal stem cells (MSCs) are key cell components that contribute to the maintenance of tissue homeostasis and exert both immunostimulatory and immunosuppressive functions. Herein, we study the effects of MV130 in human MSC functionality as a potential mechanism that contributes to its clinical benefits. We provide evidence that during MV130 sublingual immunization of mice, resident oral mucosa MSCs can take up MV130 components and their numbers remain unchanged after vaccination, in contrast to granulocytes that are recruited from extramucosal tissues. MSCs treated in vitro with MV130 show an increased viability without affecting their differentiation potential. In the short-term, MSC treatment with MV130 induces higher leukocyte recruitment and T cell expansion. In contrast, once T-cell activation is initiated, MV130 stimulation induces an up-regulated expression of immunosuppressor factors in MSCs. Accordingly, MV130-primed MSCs reduce T lymphocyte proliferation, induce the differentiation of dendritic cells with immunosuppressive features and favor M2-like macrophage polarization, thus counterbalancing the immune response. In addition, MSCs trained with MV130 undergo functional changes, enhancing their immunomodulatory response to a secondary stimulus. Finally, we show that MSCs are able to uptake, process and retain a reservoir of the TLR ligands derived from MV130 digestion which can be subsequently transferred to dendritic cells, an additional feature that also may be associated to trained immunity.

scholarly journals Enhanced efferocytosis by dendritic cells underlies memory T-cell expansion and susceptibility to autoimmune disease in CD300f-deficient mice

2016 ◽  
Vol 23 (6) ◽  
pp. 1086-1096 ◽  
Author(s):  
L Tian ◽  
S-C Choi ◽  
H-N Lee ◽  
Y Murakami ◽  
C-F Qi ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Autoimmune Disease ◽  
Cell Expansion ◽  
Memory T Cell ◽  
T Cell Expansion ◽  
Deficient Mice

scholarly journals Role of MDA5 and interferon-I in dendritic cells for T cell expansion by anti-tumor peptide vaccines in mice

2018 ◽  
Vol 67 (7) ◽  
pp. 1091-1103 ◽  
Author(s):  
Hussein Sultan ◽  
Juan Wu ◽  
Takumi Kumai ◽  
Andres M. Salazar ◽  
Esteban Celis
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cell Expansion ◽  
Peptide Vaccines ◽  
T Cell Expansion

scholarly journals Impaired IFN-α Production by Plasmacytoid Dendritic Cells Favors Regulatory T-cell Expansion That May Contribute to Breast Cancer Progression

2012 ◽  
Vol 72 (20) ◽  
pp. 5188-5197 ◽  
Author(s):  
Vanja Sisirak ◽  
Julien Faget ◽  
Michael Gobert ◽  
Nadège Goutagny ◽  
Nelly Vey ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dendritic Cells ◽  
T Cell ◽  
Cancer Progression ◽  
Regulatory T Cell ◽  
Cell Expansion ◽  
Plasmacytoid Dendritic Cells ◽  
Breast Cancer Progression ◽  
T Cell Expansion

scholarly journals Effector T Cells Boost Regulatory T Cell Expansion by IL-2, TNF, OX40, and Plasmacytoid Dendritic Cells Depending on the Immune Context

2014 ◽  
Vol 194 (3) ◽  
pp. 999-1010 ◽  
Author(s):  
Audrey Baeyens ◽  
David Saadoun ◽  
Fabienne Billiard ◽  
Angéline Rouers ◽  
Sylvie Grégoire ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Regulatory T Cell ◽  
Cell Expansion ◽  
Plasmacytoid Dendritic Cells ◽  
Effector T Cells ◽  
T Cell Expansion
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