scholarly journals Subcellular relocalization of a long-chain fatty acid CoA ligase by a suppressor mutation alleviates a respiration deficiency in Saccharomyces cerevisiae.

1994 ◽  
Vol 13 (23) ◽  
pp. 5531-5538 ◽  
Author(s):  
A. Harington ◽  
E. Schwarz ◽  
P.P. Slonimski ◽  
C.J. Herbert
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Fatty Acid ◽  
Chain Fatty Acid ◽  
Suppressor Mutation ◽  
Long Chain Fatty Acid ◽  
Coa Ligase ◽  
Respiration Deficiency ◽  
Long Chain

Localization of the synthesis of very-long-chain fatty acid in mitochondria from Saccharomyces cerevisiae

1988 ◽  
Vol 177 (1) ◽  
pp. 207-211 ◽  
Author(s):  
Jean-Jacques BESSOULE ◽  
Rene LESSIRE ◽  
Michel RIGOULET ◽  
Bernard GUERIN ◽  
Claude CASSAGNE
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Fatty Acid ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Long Chain

Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema

2004 ◽  
Vol 127B (1) ◽  
pp. 42-47 ◽  
Author(s):  
Jonathan Covault ◽  
Helen Pettinati ◽  
Darlene Moak ◽  
Timothy Mueller ◽  
Henry R. Kranzler
Keyword(s):  
Fatty Acid ◽  
Gene Polymorphism ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Coa Ligase ◽  
Long Chain

Cloning, Expression, and Chromosomal Localization of Human Long-Chain Fatty Acid-CoA Ligase 4 (FACL4)

Genomics ◽  
1998 ◽  
Vol 49 (2) ◽  
pp. 327-330 ◽  
Author(s):  
Yang Cao ◽  
Elie Traer ◽  
Guy A. Zimmerman ◽  
Thomas M. McIntyre ◽  
Stephen M. Prescott
Keyword(s):  
Fatty Acid ◽  
Chromosomal Localization ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Coa Ligase ◽  
Long Chain

scholarly journals Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals

2017 ◽  
Vol 8 (1) ◽  
Author(s):  
Tao Yu ◽  
Yongjin J. Zhou ◽  
Leonie Wenning ◽  
Quanli Liu ◽  
Anastasia Krivoruchko ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Fatty Acid ◽  
Cell Growth ◽  
Control Strategy ◽  
Dynamic Control ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
High Level ◽  
Level Production ◽  
Long Chain

Abstract Production of chemicals and biofuels through microbial fermentation is an economical and sustainable alternative for traditional chemical synthesis. Here we present the construction of a Saccharomyces cerevisiae platform strain for high-level production of very-long-chain fatty acid (VLCFA)-derived chemicals. Through rewiring the native fatty acid elongation system and implementing a heterologous Mycobacteria FAS I system, we establish an increased biosynthesis of VLCFAs in S. cerevisiae. VLCFAs can be selectively modified towards the fatty alcohol docosanol (C22H46O) by expressing a specific fatty acid reductase. Expression of this enzyme is shown to impair cell growth due to consumption of VLCFA-CoAs. We therefore implement a dynamic control strategy for separating cell growth from docosanol production. We successfully establish high-level and selective docosanol production of 83.5 mg l−1 in yeast. This approach will provide a universal strategy towards the production of similar high value chemicals in a more scalable, stable and sustainable manner.

Effects of aculeacin A and papulacandin B on Candida albicans

1984 ◽  
Vol 42 ◽  
pp. 706-707
Author(s):  
J. J. Bozzola ◽  
R. J. Mehta
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Cell Wall ◽  
Candida Albicans ◽  
Fatty Acid ◽  
Plasma Membranes ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Chemical Structures ◽  
Aculeacin A ◽  
Long Chain

Aculeacin A1 and papulacandin B2 are closely related antimycotic agents that interfere with the synthesis of alkalai-insoluble β 1-3 glucan in the cell wall of Candida albicans, Saccharomyces cerevisiae and Geotrichum lactis. The chemical structures of both agents contain a long-chain fatty acid, and both agents are strongly inhibitory to C. albicans and some other fungi while having negligible activity against bacteria or protozoa. Earlier studies involving light microscopy of aculeacin A treated cells revealed rounded, distorted cells aggregated in clumps. The sole TEM micrograph of aculeacin A treated cells showed invaginations and globular bodies associated with plasma membranes.

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