Wide-field hyperspectral 3D imaging of functionalized gold nanoparticles targeting cancer cells by reflected light microscopy

2014 ◽  
Vol 8 (5) ◽  
pp. 401-407 ◽  
Author(s):  
Sergiy Patskovsky ◽  
Eric Bergeron ◽  
David Rioux ◽  
Michel Meunier
Keyword(s):  
Gold Nanoparticles ◽  
Light Microscopy ◽  
Cancer Cells ◽  
3D Imaging ◽  
Wide Field ◽  
Functionalized Gold Nanoparticles ◽  
Reflected Light

Hyperspectral reflected light microscopy of plasmonic Au/Ag alloy nanoparticles incubated as multiplex chromatic biomarkers with cancer cells

The Analyst ◽  
2014 ◽  
Vol 139 (20) ◽  
pp. 5247-5253 ◽  
Author(s):  
Sergiy Patskovsky ◽  
Eric Bergeron ◽  
David Rioux ◽  
Mikaël Simard ◽  
Michel Meunier
Keyword(s):  
Light Microscopy ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Human Cancer ◽  
Spatial Localization ◽  
Alloy Nanoparticles ◽  
Human Cancer Cell ◽  
Plasmonic Nanoparticle ◽  
Reflected Light ◽  
Spectroscopic Identification

We report a hyperspectral reflected light microscopy system for plasmonic nanoparticle (NP) imaging, and compare with a conventional darkfield method for spatial localization and spectroscopic identification of single Au, Ag and Au/Ag alloy NPs incubated with fixed human cancer cell preparations.

scholarly journals Targeted photodynamic therapy of breast cancer cells using lactose-phthalocyanine functionalized gold nanoparticles

2018 ◽  
Vol 512 ◽  
pp. 249-259 ◽  
Author(s):  
Paula García Calavia ◽  
Isabelle Chambrier ◽  
Michael J. Cook ◽  
Alan H. Haines ◽  
Robert A. Field ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Functionalized Gold Nanoparticles ◽  
Targeted Photodynamic Therapy

N,N-Ru(ii)-p-cymene-poly(N-vinylpyrrolidone) surface functionalized gold nanoparticles: from organoruthenium complex to nanomaterial for antiproliferative activity

2021 ◽  
Author(s):  
Durairaj Gopalakrishnan ◽  
S. Saravanan ◽  
Ronald Merckx ◽  
Arumugam Madan Kumar ◽  
Themmila Khamrang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Gold Nanoparticles ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Antiproliferative Activity ◽  
First Report ◽  
Functionalized Gold Nanoparticles ◽  
Arene Complex ◽  
Colorectal Cancer Cells

The first report of a Ru(arene)metallopolymer–gold nanoconjugate to enhance the in vitro anticancer activity of Ru–arene complex in colorectal cancer cells.

scholarly journals Functionalized gold nanoparticles improve afatinib delivery into cancer cells

2015 ◽  
Vol 13 (1) ◽  
pp. 133-141 ◽  
Author(s):  
Sílvia Castro Coelho ◽  
Gabriela M Almeida ◽  
Maria Carmo Pereira ◽  
Filipe Santos-Silva ◽  
Manuel AN Coelho
Keyword(s):  
Gold Nanoparticles ◽  
Cancer Cells ◽  
Functionalized Gold Nanoparticles

Selective Recognition of Rituximab-Functionalized Gold Nanoparticles by Lymphoma Cells Studied with 3D Imaging

2009 ◽  
Vol 113 (47) ◽  
pp. 20252-20258 ◽  
Author(s):  
Angelina Weiss ◽  
Thomas C. Preston ◽  
Jesse Popov ◽  
Qifeng Li ◽  
Sherry Wu ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
3D Imaging ◽  
Selective Recognition ◽  
Lymphoma Cells ◽  
Functionalized Gold Nanoparticles

scholarly journals Use in vitro of Gold Nanoparticles Functionalized with Folic Acid as a Photothermal Agent on Treatment of HeLa Cells

2018 ◽  
Vol 62 (1) ◽  
Author(s):  
Linda Bertel Garay ◽  
Fernando Martínez Ortega ◽  
Stelia Carolina Méndez-Sanchez
Keyword(s):  
Gold Nanoparticles ◽  
Folic Acid ◽  
Cancer Cells ◽  
Hela Cells ◽  
Near Infrared ◽  
Infrared Light ◽  
Molar Ratio ◽  
Functionalized Gold Nanoparticles ◽  
Dose Dependent

<p>Folic acid (FA) is used as a recognition molecule to achieve selective internalization in cancer cells. Here functionalized gold nanoparticles with folic acid (AuNP-FA) are proposed as suitable therapeutic agents for cervix cancer cells by photothermal damage. The functionalized gold nanoparticles with folic acid were synthesized by mixing hydrogen tetrachloroaurate with folic acid in a molar ratio of 0.56/1 under radiation of mercury lamp (λ<sub>max</sub>=254 nm). HeLa cells were incubated with AuNP-FA during 48 h, then were irradiated and the cytotoxicity was analyzed 12 h after irradiation. The AuNP-FA were dose-dependent cytotoxic under irradiation and not cytotoxic in the absence of radiation. The viability of cancer cells treated with functionalized and non-functionalized gold nanoparticles (AuNPs), with and without near infrared light at 808 nm, was measured by MTT assays. This work provides useful guidance toward the synthesis of biocompatible nanomaterials for biological applications.</p>

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