Soluble ions more than particulate cobalt-alloy implant debris induce monocyte costimulatory molecule expression and release of proinflammatory cytokines critical to metal-induced lymphocyte reactivity

2009 ◽  
Vol 9999A ◽  
pp. NA-NA ◽  
Author(s):  
Marco S. Caicedo ◽  
Peter H. Pennekamp ◽  
Kyron McAllister ◽  
Joshua J. Jacobs ◽  
Nadim J. Hallab
Keyword(s):  
Proinflammatory Cytokines ◽  
Costimulatory Molecule ◽  
Cobalt Alloy ◽  
Soluble Ions ◽  
Lymphocyte Reactivity

scholarly journals Protective Role of 5-Lipoxigenase duringLeishmania infantumInfection Is Associated with Th17 Subset

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Laís Amorim Sacramento ◽  
Fernando Q. Cunha ◽  
Roque Pacheco de Almeida ◽  
João Santana da Silva ◽  
Vanessa Carregaro
Keyword(s):  
Immune Response ◽  
Proinflammatory Cytokines ◽  
Leishmania Infantum ◽  
Costimulatory Molecule ◽  
Neutrophil Migration ◽  
Protective Role ◽  
Genetic Ablation ◽  
Inflammatory Immune Response

Visceral leishmaniasis (VL) is a chronic and fatal disease caused byLeishmania infantumin Brazil. Leukocyte recruitment to infected tissue is a crucial event for the control of infections such as VL. Leucotriens are lipid mediators synthesized by 5-lipoxygenase (5-LO) and they display a protective role against protozoan parasites by inducing several functions in leucocytes. We determined the role of 5-LO activity in parasite control, focusing on the inflammatory immune response againstLeishmania infantuminfection. LTB4is released duringin vitroinfection. The genetic ablation of 5-LO promoted susceptibility in highly resistant mice strains, harboring more parasites into target organs. The susceptibility was related to the failure of neutrophil migration to the infectious foci. Investigating the neutrophil failure, there was a reduction of proinflammatory cytokines involved in the related Th17 axis released into the organs. Genetic ablation of 5-LO reduced the CD4+T cells producing IL-17, without interfering in Th1 subset.L. infantumfailed to activate DC from5-LO-/-, showing reduced surface costimulatory molecule expression and proinflammatory cytokines involved in Th17 differentiation. BLT1blockage with selective antagonist interferes with DC maturation and proinflammatory cytokines release. Thus, 5-LO activation coordinates the inflammatory immune response involved in the control of VL.

Measurement of PM2.5 and Water-Soluble Ions at Central Tokyo, Japan and Source Apportionment

2016 ◽  
Vol 2 (2) ◽  
pp. 71-78
Author(s):  
Yoshika Sekine ◽  
◽  
Nami Takahashi ◽  
Yuri Ohkoshi ◽  
Akihiro Takemasa ◽  
...  
Keyword(s):  
Source Apportionment ◽  
Water Soluble ◽  
Soluble Ions ◽  
Water Soluble Ions

The role of inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy as a result of ART

2016 ◽  
pp. 73-76
Author(s):  
B.M. Ventskivskiy ◽  
◽  
I.V. Poladych ◽  
S.O. Avramenko ◽  
◽  
...  
Keyword(s):  
Assisted Reproductive Technology ◽  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Local Level ◽  
Multiple Pregnancy ◽  
Reproductive Technology ◽  
System Level ◽  
Premature Labor ◽  
Pro Inflammatory Cytokines

In recent years there has been an increase in the frequency of multiple pregnancies and the associated perinatal losses. It is a result of multiple pregnancy in ART refers to a high-risk gestation, at which premature births occur in 2 times more often than in singleton pregnancies. The objective: to determine the role of pro-inflammatory cytokines in the pathogenesis of premature labor in multiple pregnancy, as a result of assisted reproductive technology. Patients and methods. to determine the pro-inflammatory cytokines that all pregnant with bagtopliddyam held immunosorbent assay, defined concentrations of interleukin (IL) in serum and cervical mucus. Results. The analysis of the levels of pro-inflammatory cytokines (IL-1, IL-8) in the test environment, found high concentrations in the surveyed women with multiple pregnancy, due to the use of ART, compared with spontaneous multiple and singleton pregnancy. Increased concentration of proinflammatory cytokines in patients with multiple pregnancy by ART is associated with their synthesis at the system level, it stimulated foci of inflammation in the female genitals and extragenital localization. This correlates with the clinical data and statistical analysis, patients with multiple pregnancy as a result of ART had weighed infectious-inflammatory history. Conclusion. The study showed that elevated levels of proinflammatory cytokines in the systemic and local level in patients with multiple pregnancy due to ART, typical for women with miscarriage, because of the physiological course of pregnancy characterized by the predominance of anti-inflammatory cytokines that prevent rejection of the fetus as a foreign factor. Based on the data obtained proved the role of systemic inflammatory factors in the genesis of preterm labor in women with a multiple pregnancy, as a result of assisted reproductive technology. Key words: multiple pregnancy, assisted reproductive technology, premature birth, interleukine-1, interleukine-8.

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