Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus

2009 ◽  
Vol 10 (3) ◽  
pp. 488-495 ◽  
Author(s):  
Clinton T. Rubin ◽  
Ted S. Gross ◽  
Kenneth J. McLeod ◽  
Steven D. Bain
Keyword(s):  
Bone Formation ◽  
Mechanical Stimulus ◽  
Lamellar Bone

scholarly journals Mathematical modeling of bone in-growth into undegradable porous periodic scaffolds under mechanical stimulus

2019 ◽  
Vol 10 ◽  
pp. 204173141982716 ◽  
Author(s):  
Lingze Liu ◽  
Quan Shi ◽  
Qiang Chen ◽  
Zhiyong Li
Keyword(s):  
Mathematical Modeling ◽  
Bone Formation ◽  
Growth Process ◽  
Bone Repair ◽  
Mechanical Stimulus ◽  
Clinical Applications ◽  
Mathematical Framework ◽  
Paracrine Effects ◽  
Clinical Observations ◽  
Coupling Cell

Undegradable scaffolds, as a key element in bone tissue engineering, prevail in the present clinical applications, and the bone in-growth into such scaffolds under mechanical stimulus is an important issue to evaluate the bone-repair effect. This work aims to develop a mathematical framework to investigate the effect of mechanical stimulus on the bone in-growth into undegradable scaffolds. First, the osteoclast and osteoblast activities were coupled by their autocrine and paracrine effects. Second, the mechanical stimulus was empirically incorporated into the coupling cell activities on the basis of experimental observations. Third, the effect of mechanical stimulus including intensity and duration on the bone in-growth process was numerically studied; moreover, the homeostasis of scaffold–bone system under the mechanical stimulus was also treated. The results showed that the numbers of osteoblasts and osteoclasts in the scaffold–bone system tended to constants representing the system homeostasis. Both the mechanical intensity and duration optimized the final bone formation. The numerical results of the bone formation were comparable to the experimental results in rats. The findings from this modeling study could be used to explain many physiological phenomena and clinical observations. The developed model integrates both cell and tissue scales, which can be used as a platform to investigate bone remodeling under mechanical stimulus.

Lamellar Bone Formation in an Atherosclerotic Plaque of the Carotid Artery, with a Review of Histogenesis

Angiology ◽  
2000 ◽  
Vol 51 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Steven Pauli ◽  
Patrick Lauwers ◽  
Jeroen Hendriks ◽  
Filip Van den Brande ◽  
John-Paul Bogers ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Bone Formation ◽  
Atherosclerotic Plaque ◽  
Lamellar Bone

In vivo lamellar bone formation in fibre coated MgCHA–PCL-composite scaffolds

2011 ◽  
Vol 23 (1) ◽  
pp. 117-128 ◽  
Author(s):  
Silvia Scaglione ◽  
Vincenzo Guarino ◽  
Monica Sandri ◽  
Anna Tampieri ◽  
Luigi Ambrosio ◽  
...  
Keyword(s):  
Bone Formation ◽  
Lamellar Bone ◽  
Composite Scaffolds

scholarly journals Nitric oxide-mediated vasodilation increases blood flow during the early stages of stress fracture healing

2014 ◽  
Vol 116 (4) ◽  
pp. 416-424 ◽  
Author(s):  
Ryan E. Tomlinson ◽  
Kooresh I. Shoghi ◽  
Matthew J. Silva
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Bone Formation ◽  
Mechanical Loading ◽  
Stress Fracture ◽  
Flow Rate ◽  
Vascular Function ◽  
Blood Flow Rate ◽  
Lamellar Bone ◽  
Woven Bone

Despite the strong connection between angiogenesis and osteogenesis in skeletal repair conditions such as fracture and distraction osteogenesis, little is known about the vascular requirements for bone formation after repetitive mechanical loading. Here, established protocols of damaging (stress fracture) and nondamaging (physiological) forelimb loading in the adult rat were used to stimulate either woven or lamellar bone formation, respectively. Positron emission tomography was used to evaluate blood flow and fluoride kinetics at the site of bone formation. In the group that received damaging mechanical loading leading to woven bone formation (WBF),15O water (blood) flow rate was significantly increased on day 0 and remained elevated 14 days after loading, whereas18F fluoride uptake peaked 7 days after loading. In the group that received nondamaging mechanical loading leading to lamellar bone formation (LBF),15O water and18F fluoride flow rates in loaded limbs were not significantly different from nonloaded limbs at any time point. The early increase in blood flow rate after WBF loading was associated with local vasodilation. In addition, Nos2 expression in mast cells was increased in WBF-, but not LBF-, loaded limbs. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester was used to suppress NO generation, resulting in significant decreases in early blood flow rate and bone formation after WBF loading. These results demonstrate that NO-mediated vasodilation is a key feature of the normal response to stress fracture and precedes woven bone formation. Therefore, patients with impaired vascular function may heal stress fractures more slowly than expected.

Rapid Establishment of Chemical and Mechanical Properties during Lamellar Bone Formation

2005 ◽  
Vol 77 (6) ◽  
pp. 386-394 ◽  
Author(s):  
B. Busa ◽  
L. M. Miller ◽  
C. T. Rubin ◽  
Y.-X. Qin ◽  
S. Judex
Keyword(s):  
Mechanical Properties ◽  
Bone Formation ◽  
Lamellar Bone

Osteogenesis Imperfecta of the Temporal Bone and its Relation to Otosclerosis

1988 ◽  
Vol 97 (6) ◽  
pp. 585-593 ◽  
Author(s):  
George T. Nager
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Bone Formation ◽  
Osteogenesis Imperfecta ◽  
Temporal Bone ◽  
Bone Dysplasia ◽  
Lamellar Bone ◽  
Current Classification ◽  
Sound Conduction ◽  
Loss Of Hearing

Osteogenesis imperfecta (OI) designates a heterogeneous group of heritable disorders of connective tissue that in addition to bone may affect tendons, ligaments, fascia, skin, sclerae, blood vessels, teeth, and hearing. The current classification identifies at least four major syndrome groups or types. It also recognizes a considerable number of additional syndromes that may represent supplementary types or subgroups. Loss of hearing is the least constant of the prominent features of OI. Its incidence varies between 26% and 60%. In OI, formation and remodelling of bone are variously affected. In the temporal bone the development of the inner ear capsule may be involved severely. In the stapes the disturbance in lamellar bone formation can lead to extreme thinness, dehiscence, and nonunion of the stapedial superstructure with the footplate. Osteogenesis imperfecta can be associated with otosclerosis, another bone dysplasia with a different morphology. Otosclerosis, in turn, may interfere with sound conduction and perception. Thus, the hearing loss encountered in OI may be the result of OI, otosclerosis, or a combination of both.

scholarly journals Comparison of Extragraft Bone Formation after Anterior Cervical Discectomy and Fusion Using Simultaneous and Sequential Algorithms

2021 ◽  
Vol 11 (4) ◽  
pp. 1487
Author(s):  
Yong Jun Jin ◽  
Won Man Park
Keyword(s):  
Bone Formation ◽  
Element Model ◽  
Mechanical Stimulus ◽  
Anterior Cervical Discectomy ◽  
Sequential Algorithm ◽  
Successful Outcome ◽  
Mechanical Stimuli ◽  
Sequential Algorithms ◽  
Cervical Discectomy ◽  
Spinal Fusion Surgery

Extragraft bone formation is crucial for obtaining a successful outcome after spinal fusion surgery. However, the cause of bone formation is not well investigated. In this study, it was hypothesised that extragraft bone formation is generated by mechanical stimuli. A preoperative plan for anterior cervical discectomy and fusion was applied to the finite element model of the C5–C6 motion segment. Extragraft bone formations posterior to the interbody cage were simulated using simultaneous and sequential algorithms. While the simultaneous algorithm predicted the formation of extragraft bone bridging under flexion and extension, the bridge was generated only under extension with the sequential algorithm. This was caused by an ill-defined design space in cases where the simultaneous algorithm was used. Our results using the sequential algorithm show how the progress of extragraft bone formation affects spine mechanics, and our results support the hypothesis that a mechanical stimulus is a major factor influencing extragraft bone formation.

Sign in / Sign up

Export Citation Format

Share Document