scholarly journals Histopathology of osteogenesis imperfecta bone. Supramolecular assessment of cells and matrices in the context of woven and lamellar bone formation using light, polarization and ultrastructural microscopy

Bone Reports ◽  
2020 ◽  
pp. 100734
Author(s):  
Frederic Shapiro ◽  
Kathleen Maguire ◽  
Srilatha Swami ◽  
Hui Zhu ◽  
Evelyn Flynn ◽  
...  
Keyword(s):  
Bone Formation ◽  
Osteogenesis Imperfecta ◽  
Light Polarization ◽  
Lamellar Bone

Osteogenesis Imperfecta of the Temporal Bone and its Relation to Otosclerosis

1988 ◽  
Vol 97 (6) ◽  
pp. 585-593 ◽  
Author(s):  
George T. Nager
Keyword(s):  
Hearing Loss ◽  
Connective Tissue ◽  
Bone Formation ◽  
Osteogenesis Imperfecta ◽  
Temporal Bone ◽  
Bone Dysplasia ◽  
Lamellar Bone ◽  
Current Classification ◽  
Sound Conduction ◽  
Loss Of Hearing

Osteogenesis imperfecta (OI) designates a heterogeneous group of heritable disorders of connective tissue that in addition to bone may affect tendons, ligaments, fascia, skin, sclerae, blood vessels, teeth, and hearing. The current classification identifies at least four major syndrome groups or types. It also recognizes a considerable number of additional syndromes that may represent supplementary types or subgroups. Loss of hearing is the least constant of the prominent features of OI. Its incidence varies between 26% and 60%. In OI, formation and remodelling of bone are variously affected. In the temporal bone the development of the inner ear capsule may be involved severely. In the stapes the disturbance in lamellar bone formation can lead to extreme thinness, dehiscence, and nonunion of the stapedial superstructure with the footplate. Osteogenesis imperfecta can be associated with otosclerosis, another bone dysplasia with a different morphology. Otosclerosis, in turn, may interfere with sound conduction and perception. Thus, the hearing loss encountered in OI may be the result of OI, otosclerosis, or a combination of both.

Lamellar Bone Formation in an Atherosclerotic Plaque of the Carotid Artery, with a Review of Histogenesis

Angiology ◽  
2000 ◽  
Vol 51 (1) ◽  
pp. 77-81 ◽  
Author(s):  
Steven Pauli ◽  
Patrick Lauwers ◽  
Jeroen Hendriks ◽  
Filip Van den Brande ◽  
John-Paul Bogers ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Bone Formation ◽  
Atherosclerotic Plaque ◽  
Lamellar Bone

scholarly journals Bone Formation Markers in Adults with Mild Osteogenesis Imperfecta

2007 ◽  
Vol 53 (6) ◽  
pp. 1109-1114 ◽  
Author(s):  
Tim Cundy ◽  
Anne Horne ◽  
Mark Bolland ◽  
Greg Gamble ◽  
James Davidson
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Formation ◽  
Bone Mass ◽  
Osteogenesis Imperfecta ◽  
Plasma Concentrations ◽  
Bone Alkaline Phosphatase ◽  
Type I ◽  
Low Bone Mass ◽  
Bone Formation Markers ◽  
Discriminant Ability

Abstract Background: Plasma concentrations of procollagen peptides are decreased in osteogenesis imperfecta (OI), whereas other bone formation markers may be increased. We examined the utility of combining these markers in the diagnosis of OI in adults. Methods: We measured plasma concentrations of procollagen-1 N-peptide (P1NP), osteocalcin, and bone alkaline phosphatase in 24 patients with nondeforming OI, 25 patients with low bone mass due to other causes, and 38 age- and sex-matched controls. The discriminant ability of various test combinations was assessed by the construction of ROC curves. Results: The median (range) ratio of osteocalcin to P1NP was significantly greater in patients with type I OI [1.75 (0.80–3.86)] than in controls [0.59 (0.34–0.90)] and patients with other causes of low bone mass [0.48 (0.05–1.38); P <0.0001]. This ratio allowed nearly complete differentiation between healthy controls and patients with type I OI, but not patients with type IV OI. With a cutoff of 0.97 for osteocalcin:P1NP, the sensitivity and specificity were maximized at 95% (95% CI 76%–100%) and 88% (69%–97%), respectively, for patients with other causes of low bone mass vs those with type I OI only. For patients with other causes of low bone mass vs all OI patients, sensitivity and specificity were 83% (63%–95%) and 88% (69%–97%), respectively. The addition of bone alkaline phosphatase data did not improve the discriminant ability of the osteocalcin:P1NP ratio. Conclusions: The osteocalcin:P1NP ratio is a sensitive and specific test for type I OI in adults, but it has less utility in the diagnosis of other types of nondeforming OI.

Morphologie stages in lamellar bone formation stimulated by a potent mechanical stimulus

2009 ◽  
Vol 10 (3) ◽  
pp. 488-495 ◽  
Author(s):  
Clinton T. Rubin ◽  
Ted S. Gross ◽  
Kenneth J. McLeod ◽  
Steven D. Bain
Keyword(s):  
Bone Formation ◽  
Mechanical Stimulus ◽  
Lamellar Bone

In vivo lamellar bone formation in fibre coated MgCHA–PCL-composite scaffolds

2011 ◽  
Vol 23 (1) ◽  
pp. 117-128 ◽  
Author(s):  
Silvia Scaglione ◽  
Vincenzo Guarino ◽  
Monica Sandri ◽  
Anna Tampieri ◽  
Luigi Ambrosio ◽  
...  
Keyword(s):  
Bone Formation ◽  
Lamellar Bone ◽  
Composite Scaffolds

scholarly journals Nitric oxide-mediated vasodilation increases blood flow during the early stages of stress fracture healing

2014 ◽  
Vol 116 (4) ◽  
pp. 416-424 ◽  
Author(s):  
Ryan E. Tomlinson ◽  
Kooresh I. Shoghi ◽  
Matthew J. Silva
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Bone Formation ◽  
Mechanical Loading ◽  
Stress Fracture ◽  
Flow Rate ◽  
Vascular Function ◽  
Blood Flow Rate ◽  
Lamellar Bone ◽  
Woven Bone

Despite the strong connection between angiogenesis and osteogenesis in skeletal repair conditions such as fracture and distraction osteogenesis, little is known about the vascular requirements for bone formation after repetitive mechanical loading. Here, established protocols of damaging (stress fracture) and nondamaging (physiological) forelimb loading in the adult rat were used to stimulate either woven or lamellar bone formation, respectively. Positron emission tomography was used to evaluate blood flow and fluoride kinetics at the site of bone formation. In the group that received damaging mechanical loading leading to woven bone formation (WBF),15O water (blood) flow rate was significantly increased on day 0 and remained elevated 14 days after loading, whereas18F fluoride uptake peaked 7 days after loading. In the group that received nondamaging mechanical loading leading to lamellar bone formation (LBF),15O water and18F fluoride flow rates in loaded limbs were not significantly different from nonloaded limbs at any time point. The early increase in blood flow rate after WBF loading was associated with local vasodilation. In addition, Nos2 expression in mast cells was increased in WBF-, but not LBF-, loaded limbs. The nitric oxide (NO) synthase inhibitor Nω-nitro-l-arginine methyl ester was used to suppress NO generation, resulting in significant decreases in early blood flow rate and bone formation after WBF loading. These results demonstrate that NO-mediated vasodilation is a key feature of the normal response to stress fracture and precedes woven bone formation. Therefore, patients with impaired vascular function may heal stress fractures more slowly than expected.

scholarly journals Comparable Effects of Strontium Ranelate and Alendronate Treatment on Fracture Reduction in a Mouse Model of Osteogenesis Imperfecta

2021 ◽  
Vol 2021 ◽  
pp. 1-13
Author(s):  
Changgui Shi ◽  
Bin Sun ◽  
Chao Ma ◽  
Huiqiao Wu ◽  
Rui Chen ◽  
...  
Keyword(s):  
Bone Resorption ◽  
Mouse Model ◽  
Bone Formation ◽  
Osteogenesis Imperfecta ◽  
Strontium Ranelate ◽  
Maximum Load ◽  
Inhibitory Effect ◽  
Comparable Efficacy ◽  
Mineral Density ◽  
Trabecular Bone Mineral Density

Alendronate (Aln) has been the first-line drug for osteogenesis imperfecta (OI), while the comparable efficacy of Aln and strontium ranelate (SrR) remains unclear. This study is aimed at comparing the effects of SrR and Aln treatment in a mouse model of OI. Three-week-old oim/oim and wt/wt female mice were treated with SrR (1800 mg/kg/day), Aln (0.21 mg/kg/week), or vehicle (Veh) for 11 weeks. After the treatment, the average number of fractures sustained per mouse was significantly reduced in both SrR- and Aln-treated oim/oim mice. The effect was comparable between these two agents. Both SrR and Aln significantly increased trabecular bone mineral density, bone histomorphometric parameters (bone volume, trabecular number, and cortical thickness and area), and biomechanical parameters (maximum load and stiffness) as compared with the Veh group. Both treatments reduced bone resorption parameters, with Aln demonstrating a stronger inhibitory effect than SrR. In contrast to its inhibitory effect on bone resorption, SrR maintained bone formation. Aln, however, also suppressed bone formation coupled with an inhibitory effect on bone resorption. The results of this study indicate that SrR has comparable effects with Aln on reducing fractures and improving bone mass and strength. In clinical practice, SrR may be considered an option for patients with OI when other medications are not suitable or have evident contraindications.

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