Gefitinib inhibits the cross-talk between mesenchymal stem cells and prostate cancer cells leading to tumor cell proliferation and inhibition of docetaxel activity

2013 ◽  
Vol 114 (5) ◽  
pp. 1135-1144 ◽  
Author(s):  
Cinzia Borghese ◽  
Lara Cattaruzza ◽  
Eliana Pivetta ◽  
Nicola Normanno ◽  
Antonella De Luca ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Tumor Cell ◽  
Cancer Cells ◽  
Cross Talk ◽  
Tumor Cell Proliferation ◽  
Prostate Cancer Cells ◽  
The Cross

P03-2 In prostate cancer cells metformin inhibits the cross-talk between membrane-initiated androgens and IGF-GR

2012 ◽  
Vol 22 ◽  
pp. S71
Author(s):  
R. Malaguarnera ◽  
A. Sacco ◽  
C. Voci ◽  
R. Vigneri ◽  
A. Belfiore
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cross Talk ◽  
Prostate Cancer Cells ◽  
The Cross

Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells

2018 ◽  
Vol 291 ◽  
pp. 77-85 ◽  
Author(s):  
Rasha M. Allam ◽  
Ahmed M. Al-Abd ◽  
Alaa Khedr ◽  
Ola A. Sharaf ◽  
Salwa M. Nofal ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Cross Talk ◽  
Sphingolipid Metabolism ◽  
Estrogen Metabolism ◽  
Prostate Cancer Cells ◽  
The Cross

scholarly journals NF-κB downregulation may be involved the depression of tumor cell proliferation mediated by human mesenchymal stem cells

2008 ◽  
Vol 29 (3) ◽  
pp. 333-340 ◽  
Author(s):  
Ling QIAO ◽  
Tie-jun ZHAO ◽  
Feng-ze WANG ◽  
Chang-liang SHAN ◽  
Li-hong YE ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Tumor Cell ◽  
Human Mesenchymal Stem Cells ◽  
Tumor Cell Proliferation

scholarly journals Cancer-Preventive Role of Bone Marrow-Derived Mesenchymal Stem Cells on Colitis-Associated Colorectal Cancer: Roles of Gut Microbiota Involved

2021 ◽  
Vol 9 ◽  
Author(s):  
Ruohang He ◽  
Chaoqun Han ◽  
Ying Li ◽  
Wei Qian ◽  
Xiaohua Hou
Keyword(s):  
Colorectal Cancer ◽  
Stem Cells ◽  
Bone Marrow ◽  
Cell Proliferation ◽  
Mesenchymal Stem Cells ◽  
Tumor Cell ◽  
Rna Sequencing ◽  
Ribosomal Rna ◽  
Tumor Cell Proliferation

BackgroundMesenchymal stem cells (MSCs) treatment showed promising results in inflammatory bowel disease in both rodent models and patients. Nevertheless, previous studies conducted conflicting results on preclinical tumor models treated with MSCs concerning their influence on tumor initiation and progression. This study is designed to demonstrate the role of bone marrow-derived MSCs and the potential mechanism in the colitis-associated colon cancer (CAC) model.MethodsBone marrow-derived MSCs were isolated from green fluorescent protein-transgenic mice, cultured, and identified by flow cytometry. Azoxymethane and dextran sulfate sodium were administrated to establish the CAC mouse model, and MSCs were infused intraperitoneally once per week. The mice were weighed weekly, and colon length, tumor number, and average tumor size were assessed after the mice were killed. MSC localization was detected by immunofluorescence staining; tumor cell proliferation and apoptosis were measured by immunohistochemistry staining of Ki-67 and terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick end labeling assay, respectively. The colonic tumor tissues were isolated for RNA-seq, and fecal samples were collected for 16S ribosomal RNA sequencing of the microbiome.ResultsAfter injection intraperitoneally, MSCs migrated to the intestine and inhibited the initiation of colitis-associated colorectal cancer. This inhibition effect was marked by less weight loss, longer colon length, and reduced tumor numbers. Moreover, MSCs reduced tumor cell proliferation and induced tumor cell apoptosis. Furthermore, MSCs could inhibit chronic inflammation assessed by RNA-sequencing and promote gut microbiome normalization detected by 16S ribosomal RNA sequencing.ConclusionThe results proved that MSCs could migrate to the colon, inhibit chronic inflammation, and regulate gut microbiome dysbiosis to suppress the development of CAC.

Sign in / Sign up

Export Citation Format

Share Document