The effects of fatty acids consumption on OPG/RANKL/RANK system in cardiovascular diseases: Current status and future perspectives for the impact of diet‐gene interaction

2018 ◽  
Vol 120 (3) ◽  
pp. 2774-2781 ◽  
Author(s):  
Omid Reza Tamtaji ◽  
Shokoofeh Borzabadi ◽  
Majid Ghayour‐Mobarhan ◽  
Gordon Ferns ◽  
Zatollah Asemi
RMD Open ◽  
2020 ◽  
Vol 6 (1) ◽  
pp. e001063 ◽  
Author(s):  
Berend Stoel

After decades of basic research with many setbacks, artificial intelligence (AI) has recently obtained significant breakthroughs, enabling computer programs to outperform human interpretation of medical images in very specific areas. After this shock wave that probably exceeds the impact of the first AI victory of defeating the world chess champion in 1997, some reflection may be appropriate on the consequences for clinical imaging in rheumatology. In this narrative review, a short explanation is given about the various AI techniques, including ‘deep learning’, and how these have been applied to rheumatological imaging, focussing on rheumatoid arthritis and systemic sclerosis as examples. By discussing the principle limitations of AI and deep learning, this review aims to give insight into possible future perspectives of AI applications in rheumatology.


2018 ◽  
Vol 18 (12) ◽  
pp. 1189-1203 ◽  
Author(s):  
Ho-Jae Lee ◽  
Young-Min Han ◽  
Jeong Min An ◽  
Eun A. Kang ◽  
Yong Jin Park ◽  
...  

Biomedicines ◽  
2021 ◽  
Vol 9 (10) ◽  
pp. 1466
Author(s):  
Igori Balta ◽  
Lavinia Stef ◽  
Ioan Pet ◽  
Tiberiu Iancu ◽  
Ducu Stef ◽  
...  

The destructive impact of cardiovascular diseases on health, including heart failure, peripheral artery disease, atherosclerosis, stroke, and other cardiac pathological conditions, positions these health conditions as leading causes of increased global mortality rates, thereby impacting the human quality of life. The considerable changes in modern lifestyles, including the increase in food intake and the change in eating habits, will unavoidably lead to an unbalanced consumption of essential fatty acids, with a direct effect on cardiovascular health problems. In the last decade, essential fatty acids have become the main focus of scientific research in medical fields aiming to establish their impact for preventing cardiovascular diseases and the associated risk factors. Specifically, polyunsaturated fatty acids (PUFA), such as omega 3 fatty acids, and monounsaturated fatty acids from various sources are mentioned in the literature as having a cardio-protective role, due to various biological mechanisms that are still to be clarified. This review aims to describe the major biological mechanisms of how diets rich in essential fatty acids, or simply essential fatty acid administration, could have anti-inflammatory, vasodilatory, anti-arrhythmic, antithrombotic, antioxidant, and anti-atherogenic effects. This review describes findings originating from clinical studies in which dietary sources of FAs were tested for their role in mitigating the impact of heart disorders in human health.


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