The skewed frequency of B‐cell subpopulation CD19 + CD24 hi CD38 hi cells in peripheral blood mononuclear cells is correlated with the elevated serum sCD40L in patients with active systemic lupus erythematosus

2019 ◽  
Vol 120 (7) ◽  
pp. 11490-11497
Author(s):  
Huiming Wang ◽  
Changxuan Liu ◽  
Wenli Chen ◽  
Guohua Ding
Keyword(s):  
Systemic Lupus Erythematosus ◽  
B Cell ◽  
Peripheral Blood Mononuclear Cells ◽  
Lupus Erythematosus ◽  
Mononuclear Cells ◽  
Elevated Serum ◽  
Cell Subpopulation ◽  
Systemic Lupus ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

Genomewide analysis of 6-methyladenine DNA in peripheral blood mononuclear cells of systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (3) ◽  
pp. 359-364 ◽  
Author(s):  
F Zheng ◽  
D Tang ◽  
H Xu ◽  
Y Xu ◽  
W Dai ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Peripheral Blood Mononuclear Cells ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Systemic Lupus ◽  
Peripheral Blood Mononuclear ◽  
Initial Development ◽  
Blood Mononuclear Cells ◽  
High Level

Aim The aim of this paper is to explore the expression of 6-methyladenine (6mA) DNA and to elucidate its gene regulation role in systemic lupus erythematosus (SLE). Methods Twenty SLE patients and 20 normal control healthy individuals (HCs) were included in this study. Genomic DNA was isolated from peripheral blood mononuclear cells and subsequently underwent 6mA-immunoprecipitation-sequencing (6mA-IP-Seq) after DNA quality control and 6mA precipitation. Bioinformation analysis was applied to the raw data comparing 6mA levels between SLE patients and HCs. Results We identified 5462 hypermethylation and 431 hypomethylation genes in PBMCs of individuals with SLE, which indicated that a high level of 6mA participates in the pathogenesis of SLE. Gene ontology analysis revealed that hypermethylation genes might regulate the inflammatory process, which has been well documented in the pathogenesis of SLE. Conclusion 6mA may be involved in the initial development of SLE, which may lead to its potential use as an early diagnostic marker and therapeutic target.

Vitamin D3 Alters the Expression of Toll-like Receptors in Peripheral Blood Mononuclear Cells of Patients With Systemic Lupus Erythematosus

2017 ◽  
Vol 118 (12) ◽  
pp. 4831-4835 ◽  
Author(s):  
Esmaeil Yazdanpanah ◽  
Mahmoud Mahmoudi ◽  
Maryam Sahebari ◽  
Zahra Rezaieyazdi ◽  
Seyed-Alireza Esmaeili ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Peripheral Blood Mononuclear Cells ◽  
Vitamin D3 ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Toll Like Receptors ◽  
Systemic Lupus ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells

scholarly journals Activation of the interferon-γ signaling pathway in systemic lupus erythematosus peripheral blood mononuclear cells

2009 ◽  
Vol 60 (5) ◽  
pp. 1463-1471 ◽  
Author(s):  
Thomas Karonitsch ◽  
Eva Feierl ◽  
Carl Walter Steiner ◽  
Karolina Dalwigk ◽  
Adelheid Korb ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Signaling Pathway ◽  
Peripheral Blood Mononuclear Cells ◽  
Lupus Erythematosus ◽  
Peripheral Blood ◽  
Mononuclear Cells ◽  
Interferon Γ ◽  
Systemic Lupus ◽  
Peripheral Blood Mononuclear ◽  
Blood Mononuclear Cells
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