Smad4 gene silencing enhances the chemosensitivity of human lymphoma cells to adriamycin via inhibition of the activation of transforming growth factor β signaling pathway

2019 ◽  
Vol 120 (9) ◽  
pp. 15098-15105 ◽  
Author(s):  
Qiuhuan Li ◽  
Xiaoyu Liu ◽  
Chuanli Zhao
Keyword(s):  
Growth Factor ◽  
Gene Silencing ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Lymphoma Cells ◽  
Smad4 Gene ◽  
Human Lymphoma

(+)-Isobicyclogermacrenal and spathulenol from Aristolochia yunnanensis alleviate cardiac fibrosis by inhibiting transforming growth factor β /small mother against decapentaplegic signaling pathway

2018 ◽  
Vol 33 (1) ◽  
pp. 214-223 ◽  
Author(s):  
Lan-Lan Lou ◽  
Wei Li ◽  
Bin-Hua Zhou ◽  
Lin Chen ◽  
Han-Zhuang Weng ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Cardiac Fibrosis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Inhibin B suppresses anoikis resistance and migration through the transforming growth factor‐β signaling pathway in nasopharyngeal carcinoma

2018 ◽  
Vol 109 (11) ◽  
pp. 3416-3427 ◽  
Author(s):  
Guoying Zou ◽  
Biqiong Ren ◽  
Yi Liu ◽  
Yin Fu ◽  
Pan Chen ◽  
...  
Keyword(s):  
Growth Factor ◽  
Nasopharyngeal Carcinoma ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Inhibin B ◽  
Anoikis Resistance ◽  
And Migration

scholarly journals Genetic variation in the transforming growth factor-β signaling pathway and survival after diagnosis with colon and rectal cancer

Cancer ◽  
2011 ◽  
Vol 117 (18) ◽  
pp. 4175-4183 ◽  
Author(s):  
Martha L. Slattery ◽  
Abbie Lundgreen ◽  
Jennifer S. Herrick ◽  
Roger K. Wolff ◽  
Bette J. Caan
Keyword(s):  
Rectal Cancer ◽  
Genetic Variation ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Colon And Rectal Cancer

scholarly journals Decrease of Smad4 gene expression in patients with essential thrombocythaemia may cause an escape from suppression of megakaryopoiesis by transforming growth factor-β 1

2003 ◽  
Vol 124 (2) ◽  
pp. 211-220 ◽  
Author(s):  
Hiroyuki Kuroda ◽  
Takuya Matsunaga ◽  
Takeshi Terui ◽  
Ikuta Tanaka ◽  
Rishu Takimoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Growth Factor ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Essential Thrombocythaemia ◽  
Smad4 Gene

99 TESTOSTERONE MODULATES TRANSFORMING GROWTH FACTOR β SIGNALING PATHWAY GENES IN MESENCHYMAL PLURIPOTENT C3H 10T1/2 STEM CELLS: IMPLICATIONS IN REGULATION OF BODY COMPOSITION.

2006 ◽  
Vol 54 (1) ◽  
pp. S96.5-S96
Author(s):  
R. Singh ◽  
M. Braga ◽  
J. N. Artaza ◽  
S. Bhasin ◽  
N. Gonzalez-Cadavid ◽  
...  
Keyword(s):  
Stem Cells ◽  
Body Composition ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway

2019 ◽  
Vol 10 (2) ◽  
Author(s):  
Sun Ah Nam ◽  
Wan-Young Kim ◽  
Jin Won Kim ◽  
Sang Hee Park ◽  
Hong Lim Kim ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Nlrp3 Inflammasome ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

Expression analysis of selected miR‐206 targets from the transforming growth factor‐β signaling pathway in breast cancer

2019 ◽  
Vol 120 (8) ◽  
pp. 13545-13553
Author(s):  
Mahnaz Seifi‐Alan ◽  
Ali Dianatpour ◽  
Lobat Geranpayeh ◽  
Reza Mirfakhraie ◽  
Mir D. Omrani ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Signaling Pathway ◽  
Expression Analysis ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β

scholarly journals Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma

Cells ◽  
2019 ◽  
Vol 8 (9) ◽  
pp. 960 ◽  
Author(s):  
Panagiotis Papoutsoglou ◽  
Corentin Louis ◽  
Cédric Coulouarn
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Tgfβ Signaling ◽  
Efficient Treatment ◽  
Tumor Onset ◽  
Tgfβ Signaling Pathway

Cholangiocarcinoma is a deadly cancer worldwide, associated with a poor prognosis and limited therapeutic options. Although cholangiocarcinoma accounts for less than 15% of liver primary cancer, its silent nature restricts early diagnosis and prevents efficient treatment. Therefore, it is of clinical relevance to better understand the molecular basis of cholangiocarcinoma, including the signaling pathways that contribute to tumor onset and progression. In this review, we discuss the genetic, molecular, and environmental factors that promote cholangiocarcinoma, emphasizing the role of the transforming growth factor β (TGFβ) signaling pathway in the progression of this cancer. We provide an overview of the physiological functions of TGFβ signaling in preserving liver homeostasis and describe how advanced cholangiocarcinoma benefits from the tumor-promoting effects of TGFβ. Moreover, we report the importance of noncoding RNAs as effector molecules downstream of TGFβ during cholangiocarcinoma progression, and conclude by highlighting the need for identifying novel and clinically relevant biomarkers for a better management of patients with cholangiocarcinoma.

Transforming growth factor β signaling pathway: A promising therapeutic target for cancer

2019 ◽  
Vol 235 (3) ◽  
pp. 1903-1914 ◽  
Author(s):  
Yuhong Chen ◽  
Cuixia Di ◽  
Xuetian Zhang ◽  
Jing Wang ◽  
Fang Wang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Signaling Pathway ◽  
Therapeutic Target ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Promising Therapeutic Target
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