Insulin-like growth factor binding protein-2 mediates the inhibition of DNA synthesis by transforming growth factor-? in mink lung epithelial cells

2002 ◽  
Vol 190 (1) ◽  
pp. 63-73 ◽  
Author(s):  
Feng Dong ◽  
Hai-Bin WU ◽  
Jiang Hong ◽  
Matthew M. Rechler
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Dna Synthesis ◽  
Transforming Growth Factor ◽  
Binding Protein ◽  
Lung Epithelial Cells ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Lung Epithelial ◽  
Inhibition Of Dna Synthesis

scholarly journals Distinct patterns of insulin-like growth factor binding protein (IGFBP)-2 and IGFBP-3 expression in oxidant exposed lung epithelial cells

2001 ◽  
Vol 1538 (1) ◽  
pp. 47-58 ◽  
Author(s):  
Valerie Besnard ◽  
Sophie Corroyer ◽  
Germain Trugnan ◽  
Katarina Chadelat ◽  
Elodie Nabeyrat ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Binding Protein ◽  
Lung Epithelial Cells ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Lung Epithelial ◽  
Igfbp 3

scholarly journals P2-153: Growth regulation via insulin-like growth factor binding protein-4 and -2 in lung epithelial cells and cancers

2007 ◽  
Vol 2 (8) ◽  
pp. S551 ◽  
Author(s):  
Takuya Yazawa ◽  
Hanako Sato ◽  
Hiroaki Shimoyamada ◽  
Koji Okudela ◽  
Hitoshi Kitamura
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Growth Regulation ◽  
Binding Protein ◽  
Lung Epithelial Cells ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Lung Epithelial

scholarly journals Proteomic analysis identifies insulin-like growth factor-binding protein-related protein-1 as a podocyte product

2010 ◽  
Vol 299 (4) ◽  
pp. F776-F784 ◽  
Author(s):  
Takayuki Matsumoto ◽  
Sonja Hess ◽  
Hiroshi Kajiyama ◽  
Toru Sakairi ◽  
Moin A. Saleem ◽  
...  
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Conditioned Medium ◽  
Cell Biology ◽  
Transforming Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Related Protein ◽  
Podocyte Injury ◽  
Factor Binding

The podocyte secretory proteome may influence the phenotype of adjacent podocytes, endothelial cells, parietal epithelial cells, and tubular epithelial cells but has not been systematically characterized. We have initiated studies to characterize this proteome, with the goal of further understanding the podocyte cell biology. We cultured differentiated conditionally immortalized human podocytes and subjected the proteins in conditioned medium to mass spectrometry. At a false discovery rate of <3%, we identified 111 candidates from conditioned medium, including 44 proteins that have signal peptides or are described as secreted proteins in the UniProt database. As validation, we confirmed that one of these proteins, insulin-like growth factor-binding protein-related protein-1 (IGFBP-rP1), was expressed in mRNA and protein of cultured podocytes. In addition, transforming growth factor-β1 stimulation increased IGFBP-rP1 in conditioned medium. We analyzed IGFBP-rP1 glomerular expression in a mouse model of human immunodeficiency virus-associated nephropathy. IGFBP-rP1 was absent from podocytes of normal mice and was expressed in podocytes and pseudocrescents of transgenic mice, where it was coexpressed with desmin, a podocyte injury marker. We conclude that IGFBP-rP1 may be a product of injured podocytes. Further analysis of the podocyte secretory proteome may identify biomarkers of podocyte injury.

Expression of a lactogen-dependent insulin-like growth factor-binding protein in cultured mouse mammary epithelial cells.

Endocrinology ◽  
1992 ◽  
Vol 131 (1) ◽  
pp. 261-267 ◽  
Author(s):  
P J Fielder ◽  
G Thordarson ◽  
A English ◽  
R G Rosenfeld ◽  
F Talamantes
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Mammary Epithelial Cells ◽  
Binding Protein ◽  
Mammary Epithelial ◽  
Insulin Like Growth Factor ◽  
Factor Binding

scholarly journals Lung fibrosis-associated surfactant protein A1 and C variants induce latent transforming growth factor β1 secretion in lung epithelial cells.

2015 ◽  
Vol 290 (35) ◽  
pp. 21407-21407 ◽  
Author(s):  
Meenakshi Maitra ◽  
Moushumi Dey ◽  
Wen-Cheng Yuan ◽  
Peter W. Nathanielsz ◽  
Christine Kim Garcia
Keyword(s):  
Growth Factor ◽  
Epithelial Cells ◽  
Lung Fibrosis ◽  
Transforming Growth Factor ◽  
Surfactant Protein ◽  
Transforming Growth Factor Β1 ◽  
Lung Epithelial Cells ◽  
Lung Epithelial
Sign in / Sign up

Export Citation Format

Share Document