Reduced LINC00551 expression promotes proliferation and invasion of esophageal squamous cancer by increase in HSP27 phosphorylation

2020 ◽  
Vol 236 (2) ◽  
pp. 1418-1431
Author(s):  
Xiong Peng ◽  
Yuan Zhou ◽  
Yuqiao Chen ◽  
Lu Tang ◽  
Guo Wang ◽  
...  
Keyword(s):  
Hsp27 Phosphorylation ◽  
Squamous Cancer ◽  
Proliferation And Invasion ◽  
Esophageal Squamous Cancer

scholarly journals Immune negative regulator TIPE2 inhibits cervical squamous cancer progression through Erk1/2 signaling

2019 ◽  
Vol 14 (1) ◽  
pp. 528-536
Author(s):  
Li-Qiong Huang ◽  
Bo Zheng ◽  
Yi He
Keyword(s):  
Cervical Cancer ◽  
Western Blot ◽  
Cancer Cells ◽  
Signaling Pathway ◽  
Erk Signaling ◽  
Over Expression ◽  
Squamous Cancer ◽  
Cancer Tissues ◽  
Proliferation And Invasion ◽  
Cervical Squamous Cancer

AbstractTumor necrosis factor (TNF)-α-induced protein-8-like 2, or TIPE2, is a newly found immune negative regulatory molecule. This study further investigated the role of TIPE2 on proliferation and invasion of cervical squamous cancer cells. Expression of TIPE2 was compared in cervical squamous cancer tissues and adjacent normal tissues by Western blot and immunohistochemistry (IHC). Cervical squamous cancer cell lines, SiHa and C33A, were transfected with recombinant plasmid encoding TIPE2 and tested for cytologic characteristics. The impact of TIPE2 on phosphorylation of extracellular signal-regulated kinase (Erk) signaling pathway was also tested by Western blot analysis of key factors. TIPE2 expression was higher in cervical cancer tissues than that in normal tissue. IHC score of tumor tissue was negatively associated with lymphatic metastasis. Over expression of TIPE2 effectively inhibited the proliferation of cervical cancer cells. Wound healing and transwell assay showed that over expression of TIPE2 suppressed cell migration and invasion in vitro. Meanwhile, phosphorylation of Erk1/2 and upstream mitogen-activated protein kinase kinase (MEK) 1/2 was reduced by TIPE2. TIPE2 is negatively related with development of cervical squamous cancer. TIPE2 is an inhibitory factor of proliferation and invasion of cervical squamous cancer cells, probably through inhibiting Erk signaling pathway.

scholarly journals Single-Cell Transcriptome Analyses Reveal Taxol Resistant Subpopulations in Esophageal Squamous Cancer Cells

2017 ◽  
Vol 99 (2) ◽  
pp. E627-E628
Author(s):  
H. Wu ◽  
J. Yu ◽  
S. Chen ◽  
X. Zhang ◽  
L. Yang ◽  
...  
Keyword(s):  
Single Cell ◽  
Cancer Cells ◽  
Squamous Cancer ◽  
Transcriptome Analyses ◽  
Cell Transcriptome ◽  
Single Cell Transcriptome ◽  
Esophageal Squamous Cancer

Lapatinib in combination with paclitaxel plays synergistic antitumor effects on esophageal squamous cancer

2018 ◽  
Vol 82 (3) ◽  
pp. 383-394 ◽  
Author(s):  
Xiao-fang Guo ◽  
Sai-sai Li ◽  
Xiao-fei Zhu ◽  
Qiao-hua Dou ◽  
Duan Liu
Keyword(s):  
Antitumor Effects ◽  
Squamous Cancer ◽  
Esophageal Squamous Cancer

scholarly journals Hypoxia induced changes in miRNAs and their target mRNAs in extracellular vesicles of esophageal squamous cancer cells

2020 ◽  
Vol 11 (3) ◽  
pp. 570-580 ◽  
Author(s):  
Fangyu Chen ◽  
Li Chu ◽  
Jie Li ◽  
Yu Shi ◽  
Bing Xu ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Target Mrnas ◽  
Squamous Cancer ◽  
Induced Changes ◽  
Esophageal Squamous Cancer

scholarly journals Gene expression profiling induced by histone deacetylase inhibitor, FK228, in human esophageal squamous cancer cells

2007 ◽  
Author(s):  
Isamu Hoshino ◽  
Hisahiro Matsubara ◽  
Yasunori Akutsu ◽  
Takanori Nishimori ◽  
Yasuo Yoneyama ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Expression Profiling ◽  
Cancer Cells ◽  
Histone Deacetylase ◽  
Expression Profiling ◽  
Histone Deacetylase Inhibitor ◽  
Deacetylase Inhibitor ◽  
Squamous Cancer ◽  
Esophageal Squamous Cancer

scholarly journals ABCG2/V-ATPase was associated with the drug resistance and tumor metastasis of esophageal squamous cancer cells

2012 ◽  
Vol 7 (1) ◽  
pp. 180 ◽  
Author(s):  
Lijun Huang ◽  
Qiang Lu ◽  
Yong Han ◽  
Zhe Li ◽  
Zhipei Zhang ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Cancer Cells ◽  
Tumor Metastasis ◽  
Squamous Cancer ◽  
Esophageal Squamous Cancer
Sign in / Sign up

Export Citation Format

Share Document