Exploratory Literature Meta-Analysis to Characterize the Relationship Between Early and Longer Term Body Weight Loss for Antiobesity Compounds

Abstract Background Obesity and its consequences are worldwide epidemic problem; therefore, studies with strategies and mechanisms that favor weight loss to improve outcomes in health are necessary. Effects of mushrooms on body weight are uncertain. The aim of this systematic review is to determine the efficacy of mushrooms in weight loss in animal preclinical models. Method This is a systematic review of preclinical studies of animal models of obesity (any type of non-aquatic mammal), which were exposed to edible and medicinal mushrooms orally in comparison with the control. The following databases will be used: MEDLINE (PubMed), Web of Science, BIOSIS, SCOPUS, and gray literature. There will be no restriction of language, date, or publication status. The primary outcome will be body weight loss. And the secondary outcomes include the total amount of food consumed by the animals, analysis of metabolic parameters, inflammatory mediators, mortality for any causes, and any adverse effect reported. A team of reviewers will select, in pairs and independently, the titles and abstracts, extract data from qualifying studies, and assess bias risk (using SYstematic Review Centre for Laboratory animal Experimentation SYRCLE’s risk of bias tool and the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist). The standardized mean difference (SMD) will be calculated to measure treatment effect, with 95% confidence intervals (95% CI). The heterogeneity between-study will be calculated by I2 inconsistency values and Cochran’s Q statistical test, where I2 > 50% and/or p < 0.10 suggest high heterogeneity meta-analyses of random effects will be conducted as possible. Discussion Although many experimental studies about the effects of mushrooms on obesity have already been published, there is still no consensus in the literature. This study will provide evidences of preclinical research on mushrooms and their relation to body weight loss in animal models of obesity, being non-aquatic mammals. Also, this systematic review will show the limitations and strengths of the studies available in the literature, as well as it will to encourage the financing of new studies by public health managers and governmental entities. Systematic review registration PROSPERO (CRD42019125299).

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The Relationship Between Body Weight Loss During an Induced Molt and Postmolt Egg Production, Egg Weight, and Shell Quality in Caged Layers

Poultry Science ◽

10.3382/ps.0620409 ◽

1983 ◽

Vol 62 (3) ◽

pp. 409-413 ◽

Cited By ~ 86

Author(s):

MICHAEL BAKER ◽

J. BRAKE ◽

G.R. McDANIEL

Keyword(s):

Weight Loss ◽

Body Weight ◽

Egg Production ◽

Body Weight Loss ◽

Egg Weight ◽

Shell Quality ◽

The Relationship

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The relationship between voluntary water intake, body weight loss, and number of hours of water privation in the rat.

Journal of Comparative and Physiological Psychology ◽

10.1037/h0062168 ◽

1947 ◽

Vol 40 (4) ◽

pp. 231-238 ◽

Cited By ~ 6

Author(s):

Paul S. Siegel

Keyword(s):

Weight Loss ◽

Body Weight ◽

Water Intake ◽

Body Weight Loss ◽

The Relationship

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Body weight loss reverts obesity-associated hypogonadotropic hypogonadism: a systematic review and meta-analysis

Acta Endocrinologica ◽

10.1530/eje-12-0955 ◽

2013 ◽

Vol 168 (6) ◽

pp. 829-843 ◽

Cited By ~ 197

Author(s):

Giovanni Corona ◽

Giulia Rastrelli ◽

Matteo Monami ◽

Farid Saad ◽

Michaela Luconi ◽

...

Keyword(s):

Systematic Review ◽

Bariatric Surgery ◽

Weight Loss ◽

Body Weight ◽

Meta Analysis ◽

Body Weight Loss ◽

Low Calorie ◽

Testosterone Levels ◽

Low Calorie Diet ◽

Calorie Diet

ObjectiveFew randomized clinical studies have evaluated the impact of diet and physical activity on testosterone levels in obese men with conflicting results. Conversely, studies on bariatric surgery in men generally have shown an increase in testosterone levels. The aim of this study is to perform a systematic review and meta-analysis of available trials on the effect of body weight loss on sex hormones levels.DesignMeta-analysis.MethodsAn extensive Medline search was performed including the following words: ‘testosterone’, ‘diet’, ‘weight loss’, ‘bariatric surgery’, and ‘males’. The search was restricted to data from January 1, 1969 up to August 31, 2012.ResultsOut of 266 retrieved articles, 24 were included in the study. Of the latter, 22 evaluated the effect of diet or bariatric surgery, whereas two compared diet and bariatric surgery. Overall, both a low-calorie diet and bariatric surgery are associated with a significant (P<0.0001) increase in plasma sex hormone-binding globulin-bound and -unbound testosterone levels (total testosterone (TT)), with bariatric surgery being more effective in comparison with the low-calorie diet (TT increase: 8.73 (6.51–10.95) vs 2.87 (1.68–4.07) for bariatric surgery and the low-calorie diet, respectively; both P<0.0001 vs baseline). Androgen rise is greater in those patients who lose more weight as well as in younger, non-diabetic subjects with a greater degree of obesity. Body weight loss is also associated with a decrease in estradiol and an increase in gonadotropins levels. Multiple regression analysis shows that the degree of body weight loss is the best determinant of TT rise (B=2.50±0.98, P=0.029).ConclusionsThese data show that weight loss is associated with an increase in both bound and unbound testosterone levels. The normalization of sex hormones induced by body weight loss is a possible mechanism contributing to the beneficial effects of surgery in morbid obesity.

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Glycaemic index, appetite and body weight

Proceedings of The Nutrition Society ◽

10.1017/s0029665110000091 ◽

2010 ◽

Vol 69 (2) ◽

pp. 199-203 ◽

Cited By ~ 15

Author(s):

Heather Ford ◽

Gary Frost

Keyword(s):

Weight Loss ◽

Body Weight ◽

Body Weight Loss ◽

Glycaemic Index ◽

Present Review ◽

Appetite Suppressant ◽

Carbohydrate Fermentation ◽

Fermentable Carbohydrates ◽

Index Weight ◽

The Relationship

Much interest has been focused on the relationship between glycaemic index and body-weight loss, some of which is fuelled by popular media. However, there is a number of potential mechanisms that could be triggered by reducing the glycaemic index of the carbohydrate consumed in the diet. For example, the effect of foods on the gastrointestinal tract and the effect on blood glucose both could lead to potential appetite effects. Acute meal studies seem to point to an effect of glycaemic index on appetite regulation. However, the results of longer-term studies of weight loss are not as clear. In the present review a possible reason for this variation in outcome from the weight-loss studies will be discussed. The present review focuses on the possibility that the fermentable fibre content of the low-glycaemic-index diet may be important in weight-loss efficacy. A novel receptor that binds SCFA, the products of carbohydrate fermentation, has recently been described on the enteroendocrine L-cell in the colon. This cell releases a number of anorectic hormones and could offer an explanation of the appetite suppressant effects of fermentable carbohydrates. It could also explain the variability in the results of glycaemic-index weight-loss studies.

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Meta-analysis of recommended digestible lysine levels for primiparous lactating sows

Ciência Rural ◽

10.1590/0103-8478cr20190418 ◽

2020 ◽

Vol 50 (11) ◽

Author(s):

Amélia Maria Lima Garcia ◽

Charles Kiefer ◽

Karina Márcia Ribeiro de Souza Nascimento ◽

Cheila Roberta Lehnen ◽

Luciano Hauschild ◽

...

Keyword(s):

Weight Loss ◽

Body Weight ◽

Weight Gain ◽

Crude Protein ◽

Meta Analysis ◽

Body Weight Loss ◽

Metabolizable Energy ◽

Daily Weight Gain ◽

Quadratic Effect ◽

Lactating Sows

ABSTRACT: A meta-analysis was carried out to evaluate the recommended levels of digestible lysine and its influence on the productive performance of primiparous lactating sows. The database consisted of 26 publications, 138 diets and 3,820 sows was developed from articles on the association between, lysine, crude protein and lactating primiparous sows. The digestible lysine levels of the studies ranged from 0.22 to 1.43% with average values of 0.85% digestible lysine in the diet, with consumption of 41.25 g day-1. The digestible lysine intake of sows was positively correlated (P<0.05) with feed intake, essential amino acids, crude protein, metabolizable energy, body weight loss sows, milk production, number and weight of piglets at weaning. Digestible lysine intake showed negative correlation (P<0.05) with backfat thickness at weaning and weaning to oestrus interval. It was observed a quadratic effect (P<0.01) of body weight loss sow and daily weight gain of piglets and a quadratic effect (P<0.01) in the weight of piglets at weaning due to increased dietary lysine level. The level of 1.04% of digestible lysine indicates less weight loss sows. The greater weight of piglets at weaning and increased daily weight gain of piglets was verified with the addition of 1.30 and 1.07% digestible lysine in the diet, respectively.

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