An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives under catalyst-free and solvent-free conditions

2011 ◽  
Vol 48 (4) ◽  
pp. 957-960 ◽  
Author(s):  
Lijiu Gao ◽  
Honglou Ji ◽  
Liangce Rong ◽  
Dan Tang ◽  
Yunyun Zha ◽  
...  
Keyword(s):  
Solvent Free ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions

Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction

2020 ◽  
Vol 17 (5) ◽  
pp. 403-407
Author(s):  
Rui Du ◽  
Liangliang Han ◽  
Zhongqiang Zhou ◽  
Victor Borovkov
Keyword(s):  
Reaction Time ◽  
Multicomponent Reaction ◽  
Room Temperature ◽  
Reaction Rates ◽  
Solvent Free ◽  
Hydroxyl Group ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition. Aldehydes bearing a hydroxyl group failed to produce the corresponding products.

ChemInform Abstract: An Efficient Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives under Catalyst-Free and Solvent-Free Conditions.

ChemInform ◽  
2011 ◽  
Vol 42 (50) ◽  
pp. no-no
Author(s):  
Lijiu Gao ◽  
Honglou Ji ◽  
Liangce Rong ◽  
Dan Tang ◽  
Yunyun Zha ◽  
...  
Keyword(s):  
Solvent Free ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions

scholarly journals An efficient synthesis of 3-benzylquinazolin-4(1H)-one derivatives under catalyst-free and solvent-free conditions

2012 ◽  
Vol 5 (4) ◽  
pp. 603-607 ◽  
Author(s):  
Suhui Wang ◽  
Shan Yin ◽  
Sheng Xia ◽  
Yanhui Shi ◽  
Shujiang Tu ◽  
...  
Keyword(s):  
Solvent Free ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions

Solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging

2021 ◽  
Author(s):  
Xiaoyun Ran ◽  
Qian Zhou ◽  
Jin Zhang ◽  
Shanqiang Wang ◽  
Gui Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Citric Acid ◽  
Core Structure ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
The Core ◽  
Catalyst Free ◽  
Synthesis Approach ◽  
Ethylenediamine Derivatives

Started from citric acid (CA) and ethylenediamine derivatives, a solvent-free, catalyst-free and highly yield synthesis approach for bicyclic 2-pyridones was presented. Continuing to modify the core structure, a series of...

Efficient Synthesis of Tetrahydrobenzo[b]pyrans under Solvent‐Free Conditions at Room Temperature

2006 ◽  
Vol 36 (16) ◽  
pp. 2363-2369 ◽  
Author(s):  
Liangce Rong ◽  
Xiaoyue Li ◽  
Haiying Wang ◽  
Daqing Shi ◽  
Shujiang Tu ◽  
...  
Keyword(s):  
Room Temperature ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions

Rapid and Efficient Synthesis of Optically Active Pyrazoles under Solvent-Free Conditions.

ChemInform ◽  
2005 ◽  
Vol 36 (8) ◽  
Author(s):  
J. S. Yadav ◽  
B. V. S. Reddy ◽  
G. Satheesh ◽  
P. Naga Lakshmi ◽  
S. Kiran Kumar ◽  
...  
Keyword(s):  
Optically Active ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
Solvent Free Conditions
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