Solvent-free and efficient synthesis of bicyclic 2-pyridone derivatives for endoplasmic reticulum imaging

2021 ◽  
Author(s):  
Xiaoyun Ran ◽  
Qian Zhou ◽  
Jin Zhang ◽  
Shanqiang Wang ◽  
Gui Wang ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Citric Acid ◽  
Core Structure ◽  
Solvent Free ◽  
Efficient Synthesis ◽  
The Core ◽  
Catalyst Free ◽  
Synthesis Approach ◽  
Ethylenediamine Derivatives

Started from citric acid (CA) and ethylenediamine derivatives, a solvent-free, catalyst-free and highly yield synthesis approach for bicyclic 2-pyridones was presented. Continuing to modify the core structure, a series of...

Efficient Synthesis of Novel Quinolinone Derivatives via Catalyst-free Multicomponent Reaction

2020 ◽  
Vol 17 (5) ◽  
pp. 403-407
Author(s):  
Rui Du ◽  
Liangliang Han ◽  
Zhongqiang Zhou ◽  
Victor Borovkov
Keyword(s):  
Reaction Time ◽  
Multicomponent Reaction ◽  
Room Temperature ◽  
Reaction Rates ◽  
Solvent Free ◽  
Hydroxyl Group ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions ◽  
Substituted Benzaldehydes

The synthesis of 3-(aryl(piperidin-1-yl)methyl)-4-hydroxyquinolin-2(1H)-one derivatives via catalyst-free multicomponent reaction is described. The reaction of 4-hydroxyquinolin-2(1H)-one, piperidine, and 4-chlorobenzaldehyde was carried out in different solvents and under solvent-free conditions at room temperature. The best solvent in terms of the yield and reaction time was found to be dichloromethane. Most substituted benzaldehydes reacted with 4-hydroxyquinolin-2(1H)-one and piperidine to afford corresponding products in good-to-excellent yields. Aldehydes with electronwithdrawing groups were more reactive to exhibit higher reaction rates. However, 2-substituted benzaldehydes did not react with 4-hydroxyquinolin-2(1H)-one and piperidine under the reaction condition. Aldehydes bearing a hydroxyl group failed to produce the corresponding products.

An efficient synthesis of 2,3-dihydroquinazolin-4(1H)-one derivatives under catalyst-free and solvent-free conditions

2011 ◽  
Vol 48 (4) ◽  
pp. 957-960 ◽  
Author(s):  
Lijiu Gao ◽  
Honglou Ji ◽  
Liangce Rong ◽  
Dan Tang ◽  
Yunyun Zha ◽  
...  
Keyword(s):  
Solvent Free ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions

ChemInform Abstract: An Efficient Synthesis of 2,3-Dihydroquinazolin-4(1H)-one Derivatives under Catalyst-Free and Solvent-Free Conditions.

ChemInform ◽  
2011 ◽  
Vol 42 (50) ◽  
pp. no-no
Author(s):  
Lijiu Gao ◽  
Honglou Ji ◽  
Liangce Rong ◽  
Dan Tang ◽  
Yunyun Zha ◽  
...  
Keyword(s):  
Solvent Free ◽  
Efficient Synthesis ◽  
Catalyst Free ◽  
Solvent Free Conditions

Efficient synthesis of the core structure of muraymycin and caprazamycin nucleoside antibiotics based on a stereochemically revised sulfur ylide reaction

2010 ◽  
Vol 21 (7) ◽  
pp. 763-766 ◽  
Author(s):  
Anatol P. Spork ◽  
Stefan Koppermann ◽  
Birger Dittrich ◽  
Regine Herbst-Irmer ◽  
Christian Ducho
Keyword(s):  
Core Structure ◽  
Efficient Synthesis ◽  
Nucleoside Antibiotics ◽  
The Core ◽  
Sulfur Ylide

scholarly journals Yeast ARV1 Is Required for Efficient Delivery of an Early GPI Intermediate to the First Mannosyltransferase during GPI Assembly and Controls Lipid Flow from the Endoplasmic Reticulum

2008 ◽  
Vol 19 (5) ◽  
pp. 2069-2082 ◽  
Author(s):  
Kentaro Kajiwara ◽  
Reika Watanabe ◽  
Harald Pichler ◽  
Kensuke Ihara ◽  
Suguru Murakami ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Core Structure ◽  
Membrane Anchor ◽  
Gpi Anchor ◽  
The Core ◽  
Important Protein ◽  
Efficient Delivery ◽  
Eukaryotic Proteins ◽  
Cytoplasmic Side

Glycosylphosphatidylinositol (GPI), covalently attached to many eukaryotic proteins, not only acts as a membrane anchor but is also thought to be a sorting signal for GPI-anchored proteins that are associated with sphingolipid and sterol-enriched domains. GPI anchors contain a core structure conserved among all species. The core structure is synthesized in two topologically distinct stages on the leaflets of the endoplasmic reticulum (ER). Early GPI intermediates are assembled on the cytoplasmic side of the ER and then are flipped into the ER lumen where a complete GPI precursor is synthesized and transferred to protein. The flipping process is predicted to be mediated by a protein referred as flippase; however, its existence has not been proven. Here we show that yeast Arv1p is an important protein required for the delivery of an early GPI intermediate, GlcN-acylPI, to the first mannosyltransferase of GPI synthesis in the ER lumen. We also provide evidence that ARV1 deletion and mutations in other proteins involved in GPI anchor synthesis affect inositol phosphorylceramide synthesis as well as the intracellular distribution and amounts of sterols, suggesting a role of GPI anchor synthesis in lipid flow from the ER.

scholarly journals Efficient synthesis of bis(indolyl)methanes by the alkylation of indoles with alcohols using heterogeneous CuFe2O4 catalyst

2021 ◽  
Vol 10 (3) ◽  
pp. 98-104
Author(s):  
Tuan Ha Minh ◽  
Yen Bui Hoang ◽  
Khanh Nguyen Ngoc ◽  
Thuan Ngo Thi ◽  
Hung Tran Quang ◽  
...  
Keyword(s):  
Natural Products ◽  
Catalytic Activity ◽  
Heterogeneous Catalyst ◽  
Core Structure ◽  
Efficient Synthesis ◽  
Active Compounds ◽  
The Core ◽  
Highly Efficient ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds

Bis(3-indolyl)methanes (BIM) are highly valuable and appear in the core structure of many natural products and pharmacologically active compounds (anticancer, anti-inflammatory, antiobesity, antimetastatic, antimicrobial, etc.). Herein, we have disclosed an air stable and highly efficient CuFe2O4 heterogeneous catalyst for alkylation of indoles with alcohols to give bis(3-indolyl)methanes in very good yields. The CuFe2O4 catalyst has been found to be magnetically recycled at least five times without losing significant catalytic activity.

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