scholarly journals Halving imaging time of whole brain diffusion spectrum imaging and diffusion tractography using simultaneous image refocusing in EPI

2009 ◽  
Vol 29 (3) ◽  
pp. 517-522 ◽  
Author(s):  
Timothy G. Reese ◽  
Thomas Benner ◽  
Ruopeng Wang ◽  
David A. Feinberg ◽  
Van J. Wedeen
2015 ◽  
Vol 36 (9) ◽  
pp. 3441-3458 ◽  
Author(s):  
Yu-Jen Chen ◽  
Yu-Chun Lo ◽  
Yung-Chin Hsu ◽  
Chun-Chieh Fan ◽  
Tzung-Jeng Hwang ◽  
...  

2017 ◽  
Vol 39 ◽  
pp. 103-108 ◽  
Author(s):  
Peng-Hu Wei ◽  
Zhi-Qi Mao ◽  
Fei Cong ◽  
Bo Wang ◽  
Zhi-Pei Ling ◽  
...  

2018 ◽  
Vol 103 (4) ◽  
pp. 511-516 ◽  
Author(s):  
Tzu-Hsun Tsai ◽  
Hsien-Te Su ◽  
Yung-Chin Hsu ◽  
Yao-Chia Shih ◽  
Chien-Chung Chen ◽  
...  

Background/aimWe investigated the microstructural changes in white matter of adults with amblyopia using diffusion spectrum imaging with systematic tract-based automatic analysis of the whole brain.MethodsTen adults with amblyopia (six women and four men, 33.6±10.6 years old on average) and 20 age- and sex-matched normal-sighted controls were enrolled. The mean generalised fractional anisotropy (GFA) was measured in 76 white matter tracts and compared between the experimental and control groups using a threshold-free cluster-weighted method and t-test. A 2-percentile cut-off was used to identify segments with the greatest differences between the two groups.ResultsParticipants with amblyopia had significantly lower GFA values than the controls in 11 segments located in nine white matter tracts, which included the following: left arcuate fasciculus, left frontal aslant tract, left fornix and left inferior fronto-occipital fasciculus of the association fibres; left thalamic radiations of the auditory nerve and bilateral optic radiations of the projection fibres; and genu and middle temporal gyrus of the callosal fibres. Amblyopic participants had statistically higher GFA values in the bilateral uncinate fasciculus than those of the controls.ConclusionThis preliminary study using whole-brain tractographic analysis of white matter reveals association between abnormal early visual processing and alterations in brain architecture, which may be related to various higher-level deficits, such as audiovisual integration and hand−eye coordination in patients with amblyopia.


2014 ◽  
Vol 115 (2-3) ◽  
pp. 213-225 ◽  
Author(s):  
Maelene Lohezic ◽  
Irvin Teh ◽  
Christian Bollensdorff ◽  
Rémi Peyronnet ◽  
Patrick W. Hales ◽  
...  

2021 ◽  
pp. 135245852110233
Author(s):  
Irene M Vavasour ◽  
Peng Sun ◽  
Carina Graf ◽  
Jackie T Yik ◽  
Shannon H Kolind ◽  
...  

Background: Advanced magnetic resonance imaging (MRI) methods can provide more specific information about various microstructural tissue changes in multiple sclerosis (MS) brain. Quantitative measurement of T1 and T2 relaxation, and diffusion basis spectrum imaging (DBSI) yield metrics related to the pathology of neuroinflammation and neurodegeneration that occurs across the spectrum of MS. Objective: To use relaxation and DBSI MRI metrics to describe measures of neuroinflammation, myelin and axons in different MS subtypes. Methods: 103 participants (20 clinically isolated syndrome (CIS), 33 relapsing-remitting MS (RRMS), 30 secondary progressive MS and 20 primary progressive MS) underwent quantitative T1, T2, DBSI and conventional 3T MRI. Whole brain, normal-appearing white matter, lesion and corpus callosum MRI metrics were compared across MS subtypes. Results: A gradation of MRI metric values was seen from CIS to RRMS to progressive MS. RRMS demonstrated large oedema-related differences, while progressive MS had the most extensive abnormalities in myelin and axonal measures. Conclusion: Relaxation and DBSI-derived MRI measures show differences between MS subtypes related to the severity and composition of underlying tissue damage. RRMS showed oedema, demyelination and axonal loss compared with CIS. Progressive MS had even more evidence of increased oedema, demyelination and axonal loss compared with CIS and RRMS.


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