scholarly journals Low-dose T1W DCE-MRI for early time points perfusion measurement in patients with intracranial tumors: A pilot study applying the microsphere model to measure absolute cerebral blood flow

2018 ◽  
Vol 48 (2) ◽  
pp. 543-557 ◽  
Author(s):  
Ka-Loh Li ◽  
Daniel Lewis ◽  
Alan Jackson ◽  
Sha Zhao ◽  
Xiaoping Zhu
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Low Dose ◽  
Early Time ◽  
Intracranial Tumors ◽  
Dce Mri ◽  
Time Points ◽  
Perfusion Measurement ◽  
Microsphere Model

SPECT imaging of cerebral blood flow changes induced by acute trigeminal nerve stimulation in drug-resistant epilepsy. A pilot study

2021 ◽  
Author(s):  
Beniamina Mercante ◽  
Susanna Nuvoli ◽  
Maria A. Sotgiu ◽  
Andrea Manca ◽  
Sara Todesco ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Trigeminal Nerve ◽  
Nerve Stimulation ◽  
Spect Imaging ◽  
Drug Resistant ◽  
Trigeminal Nerve Stimulation ◽  
Flow Changes ◽  
Drug Resistant Epilepsy

scholarly journals A Pilot Study to Investigate the Efficacy of Nicotine Oral Soluble Film, Lozenge and Gum in Relief of Acute Smoking Cue-provoked Craving for Cigarette in Low Dependence Smokers

2014 ◽  
Vol 10 (2) ◽  
pp. 87-95 ◽  
Author(s):  
Daniel Du ◽  
James Borders ◽  
Alex Selmani ◽  
William Waverczak
Keyword(s):  
Pilot Study ◽  
Early Time ◽  
Controlled Study ◽  
Nicotine Gum ◽  
Open Label ◽  
Time Points ◽  
Smoking Cues ◽  
Significant Difference ◽  
Nicotine Lozenge

Introduction: A new nicotine film that releases nicotine quickly may lead to faster craving relief.Aims: This study compares the efficacy of 2.5 mg nicotine film with 2 mg nicotine lozenge and 2 mg nicotine gum on relieving provoked craving in low dependence smokers.Methods: A randomised, open-label, active comparators controlled study was conducted in 120 subjects. Subjects were abstinent from smoking for 4 hours prior to being provoked with smoking cues. After post-provocation craving assessment, subjects were administered one dose of the 3 treatments: nicotine film, lozenge, or gum. Craving intensity was then assessed at 50 seconds, 3, 5, 7, 15, 20, 25 and 30 minutes after administration.Results/Findings: Three treatments reduced craving with similar maximum effects. The effect was maintained up to 30 minutes. Nicotine film significantly reduced more craving than lozenge at 50 seconds, 3 and 5 minutes. It also significantly reduced more craving than gum at 50 seconds and 3 minutes. There was no significant difference between lozenge and gum.Conclusions: Nicotine film, lozenge and gum have similar maximum craving relief. Nicotine film significantly reduced more craving than lozenge and gum at early time points. Nicotine film may be particularly useful to provide acute craving relief.

Hemodynamic effects of recombinant human erythropoietin on the central nervous system after subarachnoid hemorrhage: reduction of microcirculatory impairment and functional deficits in a rabbit model

2008 ◽  
Vol 109 (6) ◽  
pp. 1155-1164 ◽  
Author(s):  
Amanda M. Murphy ◽  
Anargyros Xenocostas ◽  
Pria Pakkiri ◽  
Ting-Yim Lee
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Subarachnoid Hemorrhage ◽  
Recombinant Human Erythropoietin ◽  
Low Dose ◽  
Saline Group ◽  
High Dose ◽  
Hemodynamic Effects ◽  
Neurological Outcomes ◽  
Human Erythropoietin

Object The authors investigated the hemodynamic effects of recombinant human erythropoietin (rhEPO) after subarachnoid hemorrhage (SAH) in rabbits. Methods The authors used male New Zealand White rabbits in this study divided into the following groups: SAH plus saline (16 rabbits), SAH plus low-dose rhEPO (16 rabbits; 1500 IU/kg on Day 0 and 500 IU/kg on Days 2 and 4), SAH plus high-dose rhEPO (10 rabbits; 1500 IU/kg on Days 0, 2, 4, and 6), and sham (6 rabbits). Computed tomography perfusion studies and CT angiography were performed for 1 hour after SAH on Day 0, and once each on Days 2, 4, 7, 9, and 16 after SAH. Assessments of neurological function and tissue histology were also performed. Results The mortality rate was significantly lower after rhEPO treatment (12%) than after saline treatment (44%) (p < 0.05). Neurological outcomes in the low-dose and high-dose rhEPO groups were better than in the saline group after SAH (p < 0.05), and the cerebral blood flow in the high-dose rhEPO group was greater than that in the saline group (p < 0.05). The mean transit time was significantly lower on Days 2 and 4 in the low-dose and high-dose rhEPO groups than in the saline group, but increased significantly on Day 7 in both groups (p < 0.05). The hematocrit increased significantly from baseline values in the high-dose and low-dose rhEPO groups on Days 4 and 7, respectively (p < 0.05). Conclusions Treatment with rhEPO after experimental SAH is associated with improved cerebral blood flow and microcirculatory flow as reflected by lower mean transit times. Improved tissue perfusion correlated with reduced mortality and improved neurological outcomes. Further investigation of the impact of increasing hematocrit on hemodynamic changes is needed.

scholarly journals Type A botulinum toxin (disport) in treatment of chronic forms of primary headache

2008 ◽  
Vol 7 (5-1) ◽  
pp. 270-275
Author(s):  
M. V. Napriyenko ◽  
V. Yu. Oknin ◽  
A. G. Sazonova ◽  
L. M. Kudayeva
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Botulinum Toxin ◽  
Pilot Study ◽  
Doppler Ultrasonography ◽  
Primary Headache ◽  
Arterial Blood Flow ◽  
Venous Outflow ◽  
Arterial Blood ◽  
Daily Headache

The aim of this investigation is to study the effect of BTA on the cerebral blood flow in patients with chronic daily headache. The analysis of Doppler ultrasonography and transcranial Dopplergraphy findings has shown the following: after the treatment 34% of the patients had no extravasal effect and in 66% of the patients it became moderate and after the treatment normal venous outflow was found in 58% of the patients . The results of the pilot study demonstrate the effect of BT-A injection on the cerebral blood flow by means of optimizing both the arterial blood flow and the venous outflow from the cavity of the skull.

scholarly journals Establishment of a Swine Model for Validation of Perfusion Measurement by Dynamic Contrast-Enhanced Magnetic Resonance Imaging

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Anika Sauerbrey ◽  
Stefan Hindel ◽  
Marc Maaß ◽  
Christine Krüger ◽  
Andreas Wissmann ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Femoral Artery ◽  
Resonance Imaging ◽  
Flow Probe ◽  
Dce Mri ◽  
Perfusion Measurement ◽  
Dynamic Contrast Enhanced ◽  
Contrast Enhanced ◽  
Perfusion Measurements

The aim of the study was to develop a suitable animal model for validating dynamic contrast-enhanced magnetic resonance imaging perfusion measurements. A total of 8 pigs were investigated by DCE-MRI. Perfusion was determined on the hind leg musculature. An ultrasound flow probe placed around the femoral artery provided flow measurements independent of MRI and served as the standard of reference. Images were acquired on a 1.5 T MRI scanner using a 3D T1-weighted gradient-echo sequence. An arterial catheter for local injection was implanted in the femoral artery. Continuous injection of adenosine for vasodilation resulted in steady blood flow levels up to four times the baseline level. In this way, three different stable perfusion levels were induced and measured. A central venous catheter was used for injection of two different types of contrast media. A low-molecular weight contrast medium and a blood pool contrast medium were used. A total of 6 perfusion measurements were performed with a time interval of about 20–25 min without significant differences in the arterial input functions. In conclusion the accuracy of DCE-MRI-based perfusion measurement can be validated by comparison of the integrated perfusion signal of the hind leg musculature with the blood flow values measured with the ultrasound flow probe around the femoral artery.

scholarly journals A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer’s disease

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0235691
Author(s):  
Kaja Falkenhain ◽  
Nancy E. Ruiz-Uribe ◽  
Mohammad Haft-Javaherian ◽  
Muhammad Ali ◽  
Pietro E. Michelucci ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Mouse Model ◽  
Voluntary Exercise ◽  
Model Of Alzheimer’S Disease

Pilot study on the effects of nitrendipine on cerebral blood flow in hypertensive patients with a history of cerebral infarction

1995 ◽  
Vol 56 (7) ◽  
pp. 649-655 ◽  
Author(s):  
Hiroaki Naritomi ◽  
Takao Shimizu ◽  
Kotaro Miyashita ◽  
Hiroshi Oe ◽  
Tohru Sawada
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Cerebral Infarction ◽  
Hypertensive Patients ◽  
History Of

Regional cerebral blood flow in endogenous psychoses: A Tc-99m HMPAO-SPECT pilot study

1989 ◽  
Vol 29 (3) ◽  
pp. 331-333 ◽  
Author(s):  
J. Schroeder ◽  
H. Sauer ◽  
K.-R. Wilhelm ◽  
T. Niedermeier ◽  
P. Georgi
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Pilot Study ◽  
Regional Cerebral Blood Flow ◽  
Regional Cerebral Blood ◽  
Hmpao Spect ◽  
Endogenous Psychoses
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