Declining antibody levels after hepatitis B vaccination in Down syndrome: A need for booster vaccination?

2017 ◽  
Vol 89 (9) ◽  
pp. 1682-1685 ◽  
Author(s):  
Noortje B. Eijsvoogel ◽  
Mirjam I. Hollegien ◽  
Vinus L. A. Bok ◽  
Arda G. Derksen−Lubsen ◽  
Felix P. J. Dikken ◽  
...  
2021 ◽  
pp. 84-85
Author(s):  
Aditya Rana ◽  
Anuradha Sood

Background: Hepatitis B(HBV) is a blood borne virus and it is one of the most important occupational hazards among healthcare workers (HCWs) & Medical students. This study aimed to measure the anti-HBs titres and to assess the seroprevalence of Hepatitis B in HCW and medical students. It was a prospective,descriptive and cross sectional hospital base Material and method: d study. Medical students and healthcare workers who had received all three doses of hepatitis B vaccination were included in the study. A total of 200 subjects , aged between 18 and Result: 62 years were taken. 182 were vaccinated and 18 were unvaccinated. 85 were males and 115 females. Seroprevalence of Hepatitis B was nil. Antibody titres were >100mIU/ml in 51.6% , 10-100mIU/ml in 16.4% & <10 mIU/ml in 31.8% respectively.Negative correlation of decreasing antibiotic titer and age was seen. HCW and medical students are at hi Conclusion: gher risk due to their continuous exposure to blood products. Vaccination should be compulsory to the HCW and medical workers in the institution as Hepatitis B is a preventable disease. Monitoring of antibody titers should be done from time to time to see waning off antibody titers after vaccination


2005 ◽  
Vol 142 (5) ◽  
pp. 333 ◽  
Author(s):  
Brian J. McMahon ◽  
Dana L. Bruden ◽  
Kenneth M. Petersen ◽  
Lisa R. Bulkow ◽  
Alan J. Parkinson ◽  
...  

HIV Medicine ◽  
2015 ◽  
Vol 16 (3) ◽  
pp. 161-167 ◽  
Author(s):  
TA O'Bryan ◽  
EA Rini ◽  
JF Okulicz ◽  
O Messner ◽  
A Ganesan ◽  
...  

2014 ◽  
Vol 21 (9) ◽  
pp. 1339-1342 ◽  
Author(s):  
James W. Keck ◽  
Lisa R. Bulkow ◽  
Gregory A. Raczniak ◽  
Susan E. Negus ◽  
Carolyn L. Zanis ◽  
...  

ABSTRACTHepatitis B antibody persistence was assessed in individuals who had previously received a vaccine booster. We measured hepatitis B surface antigen antibody (anti-HBs) levels 7 to 9 years post-hepatitis B booster in individuals with primary vaccination at birth. While 95 (91.3%) of 104 participants had detectable anti-HBs (minimum, 0.1 mIU/ml; maximum, 1,029 mIU/ml), only 43 (41%) had protective levels of ≥10 mIU/ml. Pre- and week 4 postbooster anti-HBs levels were significant predictors of hepatitis B immunity at follow-up (P< 0.001). Almost all participants had detectable anti-HBs 7 to 9 years after the hepatitis B vaccine booster, but less than half had levels ≥10 mIU/ml.


2021 ◽  
Author(s):  
Xia Zhu ◽  
Juan Wang ◽  
Ming Wang ◽  
Ling-yao Du ◽  
Yu-lin Ji ◽  
...  

Background: Hepatitis B virus (HBV) infection is still a public issue of the world. Hepatitis B vaccination is widely used as an effective measure to prevent HBV infection. This large-sample study aimed to evaluate the positive rates of hepatitis B surface antibody (anti-HBs) in youths after booster vaccination. Methods: A total of 37,788 participants were divided into two groups according to the baseline levels of anti-HBs before booster vaccination: the negative group (anti-HBs (-)); the positive group (anti-HBs (+)). Participants were tested for anti-HBs levels after receiving a booster vaccine 1 year and 4 years. Results: The positive rates of anti-HBs were 34.50%, 73.8% and 67.32% before booster vaccination at 1 year and 4 years after vaccination, respectively. At four years after the booster vaccination, the positive rates of 13 to 18 years were 47.54%, which was the lowest level among all youths age groups. In the anti-HBs (-) group, the positive conversion rates of anti-HBs were 74.62% at 1 year after receiving a booster vaccine, and 67.66% at 4 years after vaccination. In the anti-HBs (+) group, the positive maintenance rates of anti-HBs were 70.16% after 1 year, and 66.66% after 4 years. Compared with the baseline anti-HBs (+) group, the positive rates of the baseline anti-HBs (-) group were higher at 1 year and 4 years after receiving the booster vaccine. Conclusions: The positive rates of anti-HBs declined over time, especially the positive maintenance rates were the lowest at age of 13 to 18 years.


2003 ◽  
Vol 24 (10) ◽  
pp. 773-776 ◽  
Author(s):  
Ricardo Durlach ◽  
Stella Laugas ◽  
Cristina B. Freuler ◽  
Viviana E. Rodríguez ◽  
Marta Costa

AbstractThis study estimated the number of HCWs with protective antibody levels 5 and 10 years after HBV vaccination. Kaplan-Meier probabilities of protective levels were 0.95 at 60 days after vaccination, 0.87 at 5 years, and 0.79 at 10 years. Those without protective levels displayed good response 7 and 30 days after a booster


2013 ◽  
Vol 9 (9) ◽  
pp. 2002-2006 ◽  
Author(s):  
Heba Elrashidy ◽  
Ashraf Elbahrawy ◽  
Gamal El-Didamony ◽  
Mohamed Mostafa ◽  
Nilly M George ◽  
...  

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