scholarly journals Dual growth factor delivery from biofunctionalized allografts: Sequential VEGF and BMP-2 release to stimulate allograft remodeling

2017 ◽  
Vol 35 (5) ◽  
pp. 1086-1095 ◽  
Author(s):  
Farzana Sharmin ◽  
Casey McDermott ◽  
Jay Lieberman ◽  
Archana Sanjay ◽  
Yusuf Khan
Keyword(s):  
Growth Factor ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

scholarly journals PEG grafted chitosan scaffold for dual growth factor delivery for enhanced wound healing

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Amritha Vijayan ◽  
Sabareeswaran A. ◽  
G. S. Vinod Kumar
Keyword(s):  
Wound Healing ◽  
Growth Factors ◽  
Growth Factor ◽  
Treated Group ◽  
Growth Factor Delivery ◽  
Chitosan Scaffold ◽  
Collagen Formation ◽  
Dual Growth Factor Delivery

AbstractApplication of growth factors at wound site has improved the efficiency and quality of healing. Basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) induce proliferation of various cells in wound healing. Delivery of growth factor from controlled release systems protect it from degradation and also result in sustained delivery of it at the site of injury. The goal of the study was to develop a Polyethylene glycol (PEG) cross-linked cotton-like chitosan scaffold (CS-PEG-H) by freeze-drying method and chemically conjugate heparin to the scaffold to which the growth factors can be electrostatically bound and evaluate its wound healing properties in vitro and in vivo. The growth factor containing scaffolds induced increased proliferation of HaCaT cells, increased neovascularization and collagen formation seen by H and E and Masson’s trichrome staining. Immunohistochemistry was performed using the Ki67 marker which increased proliferation of cells in growth factor containing scaffold treated group. Frequent dressing changes are a major deterrent to proper wound healing. Our system was found to release both VEGF and bFGF in a continuous manner and attained stability after 7 days. Thus our system can maintain therapeutic levels of growth factor at the wound bed thereby avoiding the need for daily applications and frequent dressing changes. Thus, it can be a promising candidate for wound healing.

Effect of dual growth factor delivery using poly(lactic-co-glycolic acid) mesh on neovascularization in a mouse skin flap model

2016 ◽  
Vol 24 (4) ◽  
pp. 385-391 ◽  
Author(s):  
Min Suk Lee ◽  
Sajeesh Kumar ◽  
Wan-Geun La ◽  
Jun Sung Oh ◽  
Hae In Choi ◽  
...  
Keyword(s):  
Growth Factor ◽  
Glycolic Acid ◽  
Skin Flap ◽  
Mouse Skin ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

scholarly journals Double-layered microsphere based dual growth factor delivery system for guided bone regeneration

RSC Advances ◽  
2018 ◽  
Vol 8 (30) ◽  
pp. 16503-16512 ◽  
Author(s):  
Chun Xu ◽  
Jia Xu ◽  
Lan Xiao ◽  
Zhihao Li ◽  
Yin Xiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Regeneration ◽  
Delivery System ◽  
Drug Delivery Systems ◽  
Guided Bone Regeneration ◽  
Delivery Systems ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

Microsphere based drug delivery systems show great advantages for tissue engineering.

scholarly journals Dual growth factor delivery from bilayered, biodegradable hydrogel composites for spatially-guided osteochondral tissue repair

Biomaterials ◽  
2014 ◽  
Vol 35 (31) ◽  
pp. 8829-8839 ◽  
Author(s):  
Steven Lu ◽  
Johnny Lam ◽  
Jordan E. Trachtenberg ◽  
Esther J. Lee ◽  
Hajar Seyednejad ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tissue Repair ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery ◽  
Biodegradable Hydrogel ◽  
Hydrogel Composites ◽  
Osteochondral Tissue

Dual Growth Factor Delivery Using Biocompatible Core-Shell Microcapsules for Angiogenesis

Small ◽  
2013 ◽  
Vol 9 (20) ◽  
pp. 3468-3476 ◽  
Author(s):  
Dong Hoon Choi ◽  
Ramesh Subbiah ◽  
Ik Hwan Kim ◽  
Dong Keun Han ◽  
Kwideok Park
Keyword(s):  
Growth Factor ◽  
Core Shell ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery

Osteogenic/Angiogenic Dual Growth Factor Delivery Microcapsules for Regeneration of Vascularized Bone Tissue

2015 ◽  
Vol 4 (13) ◽  
pp. 1982-1992 ◽  
Author(s):  
Ramesh Subbiah ◽  
Mintai Peter Hwang ◽  
Se Young Van ◽  
Sun Hee Do ◽  
Hansoo Park ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Tissue ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery ◽  
Vascularized Bone

scholarly journals Nanofibrous bicomponent scaffolds for the dual delivery of NGF and GDNF: controlled release of growth factors and their biological effects

2021 ◽  
Vol 32 (1) ◽  
Author(s):  
Chaoyu Liu ◽  
Xiaohua Li ◽  
Qilong Zhao ◽  
Yuancai Xie ◽  
Xumei Yao ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Neural Differentiation ◽  
Biological Effects ◽  
In Vitro Release ◽  
Nerve Tissue ◽  
Growth Factor Delivery ◽  
Dual Growth Factor Delivery ◽  
Dual Source

AbstractElectrospun fibrous scaffolds capable of providing dual growth factor delivery in a controlled manner have distinctive advantages for tissue engineering. In this study, we have investigated the formation, structure, and characteristics/properties of fibrous bicomponent scaffolds for the dual delivery of glial cell line-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) for peripheral nerve tissue regeneration. GDNF and NGF were incorporated into core-shell structured poly(lactic-co-glycolic acid) (PLGA) and poly (d,l-lactic acid) (PDLLA) nanofibers, respectively, through emulsion electrospinning. Using dual-source dual-power electrospinning, bicomponent scaffolds composed of GDNF/PLGA fibers and NGF/PDLLA fibers with different fiber component ratios were produced. The structure, properties, and in vitro release behavior of mono- and bicomponent scaffolds were systematically investigated. Concurrent and sustained release of GDNF and NGF from bicomponent scaffolds was achieved and their release profiles could be tuned. In vitro biological investigations were conducted. Rat pheochromocytoma cells were found to attach, spread, and proliferate on all scaffolds. The release of growth factors from scaffolds could induce much improved neurite outgrowth and neural differentiation. GDNF and NGF released from GDNF/PLGA scaffolds and NGF/PDLLA scaffolds, respectively, could induce dose-dependent neural differentiation separately. GDNF and NGF released from bicomponent scaffolds exerted a synergistic effect on promoting neural differentiation.

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