Fetal Pulmonary Vein Pulsatility Index in the Third Trimester of Pregnancy as a Predictor of Small for Gestational Age

Abstract Objective: This study aimed to investigate whether the third trimester fetal cardiac diastolic function measured by selected conventional Doppler indices is affected in appropriate-for-gestational-age or macrosomic fetuses of gestational diabetic mothers with poor glycaemic control. Methods: This cross-sectional study included 93 pregnant women divided into two groups. Group 1 included 45 appropriate-for-gestational-age or macrosomic fetuses from gestational diabetic mothers with poor glycaemic control (study group). Group 2 included 48 appropriate-for-gestational-age fetuses from gestational age-matched healthy mothers (control group). Functional fetal cardiac parameters and fetoplacental Doppler parameters were measured. Data were compared between the two groups. Results: Maternal characteristics did not differ significantly between the study and the control group. There were no significant differences in the early and late velocity, early/late velocity ratio of both mitral and tricuspid valves, the fetal pulmonary vein pulsatility index, and the ductus venosus pulsatility index between the study and the control group. Moreover, the rate of abnormal Doppler findings in pulmonary vein (pulmonary vein pulsatility index >95th centile), ductus venosus (ductus venosus pulsatility index >95th centile), and peripheral vessels (umbilical artery pulsatility index >95th centile, middle cerebral artery pulsatility index <5th centile, cerebra-placental index >95th centile) were comparable in both groups. Conclusions: The third trimester fetal diastolic functions measured by selected conventional Doppler techniques do not seem to be altered in appropriate-for-gestational-age or macrosomic fetuses of gestational diabetic mothers who have poor glycaemic control.

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OC20.06: Angiogenic factors versus Doppler evaluation in the third trimester for the identification of late-onset small-for-gestational age births

Ultrasound in Obstetrics and Gynecology ◽

10.1002/uog.13595 ◽

2014 ◽

Vol 44 (S1) ◽

pp. 47-48

Author(s):

S. Triunfo ◽

M. Parra-Saavedra ◽

F. Crovetto ◽

V. Rodriguez-Sureda ◽

C. Dominguez ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Late Onset ◽

Angiogenic Factors ◽

Third Trimester ◽

The Third ◽

Doppler Evaluation

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Comparative assessment of informational content of the equations of F.P. Hadlock and the computer program of V.N. Demidov in determination of term of gestation and fetal weight in the III trimester of gestation

10.21516/2413-1458-2017-16-2-145-150 ◽

2017 ◽

Author(s):

E.A. Derkach , O.I. Guseva

Keyword(s):

Computer Program ◽

High Precision ◽

Gestational Age ◽

Computer Programs ◽

Comparative Assessment ◽

Fetal Weight ◽

Informational Content ◽

Third Trimester ◽

The Third

Objectives: to compare the accuracy of equations F.P. Hadlock and computer programs by V.N. Demidov in determining gestational age and fetal weight in the third trimester of gestation. Materials: 328 patients in terms 36–42 weeks of gestation are examined. Ultrasonography was performed in 0–5 days prior to childbirth. Results: it is established that the average mistake in determination of term of pregnancy when using the equation of F.P. Hadlock made 12,5 days, the computer program of V.N. Demidov – 4,4 days (distinction 2,8 times). The mistake within 4 days, when using the equation of F.P. Hadlock has met on average in 23,1 % of observations, the computer program of V.N. Demidov — 65,9 % (difference in 2,9 times). The mistake more than 10 days, took place respectively in 51,7 and 8,2 % (distinction by 6,3 times). At a comparative assessment of size of a mistake in determination of fetal mass it is established that when using the equation of F.P. Hadlock it has averaged 281,0 g, at application of the computer program of V.N. Demidov — 182,5 g (distinction of 54 %). The small mistake in the mass of a fetus which isn't exceeding 200 g at application of the equation of F.P. Hadlock has met in 48,1 % of cases and the computer program of V.N. Demidov — 64,0 % (distinction of 33,1 %). The mistake exceeding 500 g has been stated in 18 % (F.P. Hadlock) and 4,3 % (V.N. Demidov) respectively (distinction 4,2 times). Conclusions: the computer program of V.N. Demidov has high precision in determination of term of a gestation and mass of a fetus in the III pregnancy.

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66919 Third trimester electronic cigarette use and the risk of preterm birth, low birthweight, and small-for-gestational age

Journal of Clinical and Translational Science ◽

10.1017/cts.2021.714 ◽

2021 ◽

pp. 1-2

Author(s):

Lin Ammar ◽

Pingsheng Wu

Keyword(s):

Preterm Birth ◽

Gestational Age ◽

Small For Gestational Age ◽

Low Birthweight ◽

Electronic Cigarette ◽

Cigarette Use ◽

Third Trimester

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The sFlt-1 to PlGF Ratio in Pregnant Women with Rheumatoid Arthritis: Impact of Disease Activity and Sulfasalazine Use

Rheumatology ◽

10.1093/rheumatology/keab372 ◽

2021 ◽

Author(s):

Rugina I Neuman ◽

Hieronymus T W Smeele ◽

A H Jan Danser ◽

Radboud J E M Dolhain ◽

Willy Visser

Keyword(s):

Rheumatoid Arthritis ◽

Cohort Study ◽

Disease Activity ◽

Pregnant Women ◽

Gestational Age ◽

Third Trimester ◽

Low Disease Activity ◽

The Third ◽

Observational Prospective Cohort Study ◽

Plgf Ratio

Abstract Objectives An elevated sFlt-1/PlGF-ratio has been validated as a significant predictor of preeclampsia, but has not been established in women with rheumatoid arthritis (RA). We explored whether the sFlt-1/PlGF-ratio could be altered due to disease activity in RA, and could be applied in this population to predict preeclampsia. Since sulfasalazine has been suggested to improve the angiogenic imbalance in preeclampsia, we also aimed to examine whether sulfasalazine could affect sFlt-1 or PlGF levels. Methods Making use of a nationwide, observational, prospective cohort study on pregnant women with RA, sFlt-1 and PlGF were measured in the third trimester. A total of 221 women, aged 21–42 years, were included, with a median gestational age of 30 + 3 weeks. Results No differences in sFlt-1 or PlGF were observed between women with high, intermediate or low disease activity (p= 0.07 and p= 0.41), whereas sFlt-1 and PlGF did not correlate with DAS28-CRP score (r=-0.01 and r=-0.05, respectively). Four (2%) women with a sFlt-1/PlGF-ratio ≤38 developed preeclampsia in comparison to three (43%) women with a ratio > 38, corresponding to a negative predictive value of 98.1%. Sulfasalazine users (n = 57) did not show altered levels of sFlt-1 or PlGF in comparison to non-sulfasalazine users (n = 164, p= 0.91 and p= 0.11). Conclusion Our study shows that in pregnant women with RA, the sFlt-1/PlGF-ratio is not altered due to disease activity and a cut-off ≤38 can be used to exclude preeclampsia. Additionally, sulfasalazine use did not affect sFlt-1 or PlGF levels in this population.

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Third trimester ultrasound estimated fetal weight for increasing prenatal prediction of small-for-gestational age newborns in low-risk pregnant women

The Journal of Maternal-Fetal & Neonatal Medicine ◽

10.1080/14767058.2021.1920915 ◽

2021 ◽

pp. 1-6

Author(s):

Giovanna Martín-Palumbo ◽

Vangeliya Blagoeva Atanasova ◽

María Teresa Rego Tejeda ◽

Eugenia Antolín Alvarado ◽

José Luis Bartha

Keyword(s):

Pregnant Women ◽

Gestational Age ◽

Small For Gestational Age ◽

Low Risk ◽

Fetal Weight ◽

Third Trimester ◽

Estimated Fetal Weight

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Longitudinal electrophysiological study of auditory pathway in small for gestational age infants

CoDAS ◽

10.1590/2317-1782/201420140042 ◽

2014 ◽

Vol 26 (4) ◽

pp. 294-301 ◽

Cited By ~ 2

Author(s):

Rosanna Giaffredo Angrisani ◽

Edna Maria Albuquerque Diniz ◽

Ruth Guinsburg ◽

Alexandre Archanjo Ferraro ◽

Marisa Frasson de Azevedo ◽

...

Keyword(s):

Gestational Age ◽

Small For Gestational Age ◽

Neonatal Period ◽

Electrophysiological Study ◽

Auditory Pathway ◽

Prospective Longitudinal Study ◽

The Third ◽

Significant Difference ◽

Brainstem Response ◽

Prospective Longitudinal

PURPOSE: To follow the maturation of the auditory pathway of infants born small for gestational age term, by studying absolute and interpeak latencies of Auditory Brainstem Response (ABR) in the first six months of life.METHODS: Multicentric prospective longitudinal study. The ABR was carried out in the neonatal period in 96 newborn infants, 49 small for gestational age (SGA) and 47 appropriate for gestational age (AGA). Of these, 77 infants (39 SGA and 38 AGA) returned for a second evaluation. In the third evaluation, 70 infants (35 SGA and 35 AGA) returned.RESULTS: SGA and AGA did not present significant differences in the neonatal period and at three months of life. However, at six months, there was statistical significant difference between SGA and AGA groups for the latencies of wave III and interpeak I-III. Latencies of ABR waves decreased more rapidly in the first three months than the third to the sixth month of life for the SGA. AGA group showed progressive decrease in latency of ABR waves during the six months.CONCLUSION: The findings suggest that, for SGA infants, the maturational process of the auditory pathway occurs in different rate when compared to AGA infants. The SGA infants have faster maturation especially at the first three months of life, while in infants AGA, this process occurred in a constant and gradual way throughout the six months studied.

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