Comparison of Ahiflower oil containing stearidonic acid to a high‐alpha‐linolenic acid flaxseed oil at two levels on tissue omega‐3 enrichment in broilers

Background. Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. Methods. We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer’s disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. Results. During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia. Conclusions. Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.

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The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke

Biochimie ◽

10.1016/j.biochi.2015.06.005 ◽

2016 ◽

Vol 120 ◽

pp. 49-55 ◽

Cited By ~ 21

Author(s):

Nicolas Blondeau

Keyword(s):

Linolenic Acid ◽

Omega 3 ◽

Alpha Linolenic Acid

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Oxidative stability of alpha-linolenic acid (ω-3) in flaxseed oil microcapsules fortified market milk

International Journal of Dairy Technology ◽

10.1111/1471-0307.12326 ◽

2016 ◽

Vol 70 (2) ◽

pp. 188-196 ◽

Cited By ~ 4

Author(s):

Ankit Goyal ◽

Vivek Sharma ◽

Manvesh Kumar Sihag ◽

Ashish Kumar Singh ◽

Sumit Arora ◽

...

Keyword(s):

Oxidative Stability ◽

Linolenic Acid ◽

Flaxseed Oil ◽

Alpha Linolenic Acid

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Dietary α-linolenic acid from flaxseed oil improved folliculogenesis and IVF performance in dairy cows, similar to eicosapentaenoic and docosahexaenoic acids from fish oil

Reproduction ◽

10.1530/rep-13-0244 ◽

2013 ◽

Vol 146 (6) ◽

pp. 603-614 ◽

Cited By ~ 24

Author(s):

U Moallem ◽

A Shafran ◽

M Zachut ◽

I Dekel ◽

Y Portnick ◽

...

Keyword(s):

Fish Oil ◽

Dairy Cows ◽

Linolenic Acid ◽

Post Partum ◽

Saturated Fat ◽

Docosapentaenoic Acid ◽

Flaxseed Oil ◽

Omega 3 ◽

Cleavage Rate

The objectives of this study were to determine the differential incorporation of various omega-3 (n-3) fatty acids (FAs) supplemented to dairy cows into ovarian compartments and assess the effects on IVF. Forty-two 256-day pregnant cows were supplemented with encapsulated fats, in treatments designated as i) SFA – saturated fat at 240 and 560 g/day per cow, prepartum and post partum (PP) respectively; ii) FLX – flaxseed oil at 300 and 700 g/day per cow prepartum and PP respectively; and iii) FO – fish oil at 300 and 700 g/day per cow prepartum and PP respectively. Commencing at 60 days in lactation, ovum pickup (OPU) was performed twice weekly (20 sessions; five cows per group) and in vitro maturation and IVF were conducted. The proportion of α-linolenic acid (ALA) was greater in follicular fluid (FF), granulosa cells, and cumulus–oocyte complexes (COCs) of FLX cows than in other groups (P<0.001). The proportion of docosahexaenoic acid (DHA) was 6.7 times as great in FF of FO as in other groups (P<0.001); docosapentaenoic acid n-3 and DHA were detected in COCs of FO but not in others. The follicle number during OPU was higher in FLX and FO than in SFA (P<0.05), and the oocyte cleavage rate was higher in FLX and FO than in SFA (P<0.01). Also, the percentage of oocytes that developed to blastocysts tended to be higher in both n-3 groups than in SFA (P<0.1). In conclusion, both dietary n-3 FAs similarly improved folliculogenesis and IVF performance; therefore, ALA-rich botanical n-3 seems to be a satisfactory approach to improve oocyte quality.

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Changes in the content of gamma-linolenic C18:3 (n-6) and stearidonic C18:4 (n-3) acids in developing seeds of viper's bugloss Echium vulgare L.

Acta Biochimica Polonica ◽

10.18388/abp.2007_3148 ◽

2007 ◽

Vol 54 (4) ◽

pp. 741-746 ◽

Cited By ~ 2

Author(s):

Andrzej Stolyhwo ◽

Jolanta Mol

Keyword(s):

Fatty Acids ◽

Linolenic Acid ◽

Seed Oil ◽

Family Members ◽

Stearidonic Acid ◽

Alpha Linolenic Acid ◽

Developing Seeds ◽

Competitive Action

Changes in the composition of fatty acids (FA) were determined in lipid extracts isolated from developing ovaries containing ovules and developing seeds of Echium vulgare L. The samples were collected successively over 20 days beginning with the first day after flowering. The contents of the n-6 FA family members, i.e., gamma-linolenic (GLA) (C(18:3)) and linoleic (LA) (C(18:2)) acids changed in a parallel manner and reached the maximum of 13.9% and 24%, respectively, on the 12th day, after which they fell systematically down to 8.6% and 18.2%, respectively, on the 20th day after flowering. Starting with day 13, the content of alpha-linolenic acid (ALA) (C(18:3) n-3) begins to grow intensively, from 24.2% to 39.3% on the 20th day after flowering. The increase in the content of stearidonic acid (SDA) (C(18:4) n-3), up to 10.5% on the 20th day after flowering, occurred steadily as the seeds developed, and was independent of the changes in the content of GLA and LA. The pattern of changes in the content of SDA, GLA, LA and ALA during the development of seeds, and the occurrence of SDA in the seed oil of other plants, demonstrate that the biosynthesis of SDA in the seeds is critically dependent on the presence of ALA. The above condition indicates that SDA biosynthesis in the seeds of Echium vulgare follows the scheme LA --> simultaneous, competitive, action of Delta(6) and Delta(15) desaturases, leading to the formation of GLA and ALA, respectively, and then ALA (Delta(6) des) --> SDA. The biosynthesis according to the scheme: GLA (Delta(15) des) --> SDA is highly unlikely.

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Alpha ‐ linolenic acid (ALA)‐ rich flaxseed oil (FO) enhances the effectiveness of trastuzumab (TRAS) in reducing the growth of HER2 overexpressing human breast cancer tumors (BT‐474)

The FASEB Journal ◽

10.1096/fasebj.23.1_supplement.897.10 ◽

2009 ◽

Vol 23 (S1) ◽

Author(s):

Julie Kathleen Mason ◽

Jennifer S Truan ◽

Lilian U Thompson ◽

Jianmin Chen

Keyword(s):

Breast Cancer ◽

Linolenic Acid ◽

Human Breast Cancer ◽

Flaxseed Oil ◽

Human Breast ◽

Alpha Linolenic Acid

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Flax Seed

Gastroenterology Pancreatology and Hepatobilary Disorders ◽

10.31579/2641-5194/045 ◽

2021 ◽

Vol 5 (5) ◽

pp. 01-02

Author(s):

Hayriye Alp

Keyword(s):

Oleic Acid ◽

Linoleic Acid ◽

Linolenic Acid ◽

Seed Oil ◽

Linseed Oil ◽

Flaxseed Oil ◽

Flax Seed ◽

Alpha Linolenic Acid ◽

Flax Oil ◽

Secoisolariciresinol Diglycoside

Flax sed also known as flax oil and linseed oil, is derived from the seeds of the plant Linium usitatissimum. Flax seed oil is a very rich source of alpha-linolenic acid. Alpha-linolenic acid concentration in flaxseed oil ranges from approximately 40 to 60%.lower amounts of linoleic acid and oleic acid (each about 15%) are also present in flaxseed oil.ın addition, flaxseed contains varying amounts of the lignan, secoisolariciresinol diglycoside (SDG).

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