scholarly journals The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke

Biochimie ◽  
2016 ◽  
Vol 120 ◽  
pp. 49-55 ◽  
Author(s):  
Nicolas Blondeau
Keyword(s):  
Linolenic Acid ◽  
Omega 3 ◽  
Alpha Linolenic Acid

scholarly journals Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer’s Dementia in the Oldest Old

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 461
Author(s):  
Debora Melo van Lent ◽  
Sarah Egert ◽  
Steffen Wolfsgruber ◽  
Luca Kleineidam ◽  
Leonie Weinhold ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Eicosapentaenoic Acid ◽  
Linolenic Acid ◽  
Oldest Old ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Multicenter Cohort Study ◽  
Cognitive Health ◽  
Apoe Ε4 ◽  
Serum Phospholipids

Background. Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. Methods. We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer’s disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. Results. During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia. Conclusions. Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age.

Omega-3 Alpha Linolenic Acid Does Not Reflect the Entire Omega-3 Fatty Acid Family

2006 ◽  
Vol 102 (4) ◽  
pp. 1289-1290
Author(s):  
St??phanie Chevalier ◽  
Jordi P??rez ◽  
Yoram Shir
Keyword(s):  
Fatty Acid ◽  
Linolenic Acid ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Omega 3 Fatty Acid

Effects of Maternal Supplementation With Omega-3 Precursors on Human Milk Composition

2017 ◽  
Vol 33 (2) ◽  
pp. 319-328 ◽  
Author(s):  
Evelyne Mazurier ◽  
Virginie Rigourd ◽  
Paul Perez ◽  
Rachel Buffin ◽  
Leslie Couedelo ◽  
...  
Keyword(s):  
Human Milk ◽  
Olive Oil ◽  
Linolenic Acid ◽  
Rapeseed Oil ◽  
Control Diet ◽  
Milk Composition ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Fa Composition ◽  
Trans Fa

Background: Long-chain polyunsaturated fatty acids (LC-PUFAs) are important for newborn neurosensory development. Supplementation of breastfeeding mothers’ diets with omega-3 PUFAs, such as alpha-linolenic acid (ALA), may increase their concentration in human milk. Research aim: This study aimed to assess human milk composition after 15-day supplementation regimens containing either omega-3 PUFAs or olive oil, which does not provide ALA. Methods: A multicenter factorial randomized trial was conducted with four groups of breastfeeding women, with each group containing 19 to 22 women. After a 15-day ALA washout period, three groups received supplementation with omega-3 precursors for 15 days: an enriched margarine (M), a rapeseed oil (R), and a margarine and rapeseed oil (MR). The fourth was unexposed to omega-3 precursors (olive oil control diet, O). After 15 days, blind determination of human milk fatty acid (FA) composition was assessed by gas chromatography, and the FA composition was compared among groups using variance analyses. Results: Alpha-linolenic acid content, expressed as the mean (standard deviation) total human milk FA percentage, was significantly higher after diet supplementation with omega-3 PUFAs, with values of 2.2% (0.7%) (MR), 1.3% (0.5%) (R), 1.1% (0.4%) (M), and 0.8% (0.3%) (O at D30) ( p < .003 for each comparison). The lowest LA–ALA ratio (5.5) was found in the MR group ( p < .001). Docosahexaenoic acid and trans FA concentrations did not differ among groups. Conclusion: In lactating women, omega-3 supplementation via the combination of enriched margarine and rapeseed oil increased the ALA content of human milk and generated the most favorable LA–ALA ratio for LC-PUFA synthesis.

The alpha-linolenic Acid Content of Green Vegetables Commonly Available in Australia

2001 ◽  
Vol 71 (4) ◽  
pp. 223-228 ◽  
Author(s):  
Christine Pereira ◽  
Duo Li ◽  
Andrew J. Sinclair
Keyword(s):  
Fatty Acids ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Acid Composition ◽  
Acid Content ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Brussels Sprouts ◽  
Total Fatty Acids

Green vegetable consumption has long been considered to have health benefits mainly due to the vitamins, minerals and phytonutrients (such as vitamin C, folate, antioxidants etc) contained in a vegetable-rich diet. Additionally, green vegetables are known to contain a relatively high proportion of omega-3 polyunsaturated fatty acids (PUFAs), primarily in the form of alpha-linolenic acid (18:3n-3). However, there are no data available on the fatty acid composition and concentration of green vegetables commonly consumed in Australia. The present study determined the fatty acid content of 11 green vegetables that are commonly available in Australia. The total fatty acid concentrations of the vegetables under study ranged from 44 mg/100 g wet weight in Chinese cabbage to 372 mg/100 g in watercress. There were three PUFAs in all vegetables analyzed; these were 16:3n-3, 18:2n-6, and 18:3n-3 fatty acids. Sample vegetables contained significant quantities of 16:3n-3 and 18:3n-3, ranging from 23 to 225 mg/100g. Watercress and mint contained the highest amounts of 16:3n-3 and 18:3n-3, and parsley had the highest amount of 18:2n-6 in both percentage composition and concentration. Mint had the highest concentration of 18:3n-3 with a value of 195 mg/100 g, while watercress contained the highest concentration of 16:3n-3 at 45 mg/100 g. All 11 green vegetables contained a high proportion of PUFAs, ranging from 59 to 72% of total fatty acids. The omega-3 PUFA composition ranged from 40 to 62% of total fatty acids. Monounsaturated fatty acid composition was less than 6% of total fatty acids. The proportion of saturated fatty acids ranged from 21% in watercress and mint to 32% of total fatty acids in Brussels sprouts. No eicosapentaenoic and docosahexaenoic acids were detected in any of the samples. Consumption of green vegetables could contribute to 18:3n-3 PUFA intake, especially for vegetarian populations.

RAISED OMEGA-3 FATTY ACID LEVELS IN PIGS FED FLAX

1990 ◽  
Vol 70 (1) ◽  
pp. 251-254 ◽  
Author(s):  
STEPHEN C. CUNNANE ◽  
SUJATA GANGULI ◽  
JULIA K. ARMSTRONG ◽  
PAUL A. STITT
Keyword(s):  
Fatty Acids ◽  
Linolenic Acid ◽  
Subcutaneous Adipose Tissue ◽  
Growing Pigs ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Omega 3 Fatty Acid ◽  
Creep Feed ◽  
Subcutaneous Adipose

Young growing pigs fed a creep feed containing 5% flax for 8 wk had significantly higher amounts of omega-3 fatty acids in liver, kidney, heart, skin, subcutaneous adipose tissue, and muscle than pigs fed the same diet containing no flax. Increased amounts of desaturation-elongation products of alpha-linolenic acid were observed in liver, heart, kidney and brain. Key words: Flax, alpha-linolenic acid, eicosapentaenoic acid, linoleic acid, arachidonic acid

scholarly journals Insufficient intake of alpha-linolenic fatty acid (18:3n-3) during pregnancy and associated factors

2017 ◽  
Vol 30 (4) ◽  
pp. 443-453
Author(s):  
Letícia Garcia VASCONCELOS ◽  
Caroline de Barros GOMES ◽  
Maíra Barreto MALTA ◽  
Isaias DICHI ◽  
Maria Helena D’Aquino BENÍCIO ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Pregnant Women ◽  
Linolenic Acid ◽  
Dietary Lipid ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Binary Logistic Regression Model ◽  
Maternal Characteristics ◽  
Acid Intake ◽  
Linolenic Fatty Acid

ABSTRACT Objective: To analyze alpha-linolenic fatty acid intake in two cohorts of pregnant women, and to identify factors associated with alpha-linolenic acid intake. Methods: This is a cohort study involving pregnant women with low obstetric risk (N=353) in public health system from a municipality of São Paulo state, Brazil. In each trimester, two 24-hour food recalls were collected. Descriptive analyses of dietary lipid profiles were performed, followed by a multiple comparison test. According to the trimester of pregnancy, differences were assessed using the mean difference test. To evaluate the adequacy of linoleic fatty acid and alpha-linolenic acid intake, the adequate intake test was used. The association between alpha-linolenic acid intake adequacy and maternal characteristics was investigated using a binary logistic regression model. Results: Total lipids intake and the percentage contribution to dietary energy met recommended levels. One-third of the diets demonstrated a lower than daily recommended intake of alpha-linolenic acid. Overweight pregnant women were twice as likely to have inadequate alpha-linolenic acid intake. Pregnant women from a more disadvantaged socioeconomic situation had greater risks of inadequate intake. Conclusion: Over-intake of lipids is not problematic, but quality is an issue, with one third of the pregnant women and their fetuses exposed to adverse effects due to low intake of omega-3 fatty acids, indicating important nutritional vulnerability in this population.

scholarly journals Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition

RSC Advances ◽  
2017 ◽  
Vol 7 (65) ◽  
pp. 40946-40951 ◽  
Author(s):  
Shun-he Wang ◽  
Yong Pan ◽  
Jing Li ◽  
Hai-qin Chen ◽  
Hao Zhang ◽  
...  
Keyword(s):  
Linolenic Acid ◽  
Fatty Acid Biosynthesis ◽  
Product Inhibition ◽  
Chain Fatty Acid ◽  
Omega 3 ◽  
Alpha Linolenic Acid ◽  
Acid Biosynthesis ◽  
Long Chain Fatty Acid ◽  
Long Chain

Previous studies have suggested that dietary alpha-linolenic acid (ALA) increases the levels of omega-3 long-chain polyunsaturated fatty acids (ω-3 LC-PUFAs)in vivo, but the conversion procedure and the genes involved remain poorly understood.

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