Neglected pain in neonates leads to various ill effects and it can be prevented by using simple and safe non-pharmacological
pain relieving measures. Pharmacologic agents are not recommended in neonates for acute pain due toinvasive procedures
however, administration of 24% oralsucrose solutionis found to be effective. The objective of this study was to assess the
efficacy of 24%oral sucrose in combination with Facilitated tucking during BCG Vaccination through intradermalroute in
term neonates which is not done elsewhere. Fifty five healthy term neonates who fulfilled the inclusion criteria such as
gestational age above 37 weeks, within 24 hoursof birth age, and neonates delivered only through spontaneous vaginal
delivery were included in the study. The study intervention consists of administration of 2 ml of oral 24% sucrose 2 minutes
before BCG Vaccination through intradermal route and Facilitated tuckingat the time of vaccination. The primary outcome
measure of cumulative NIPS score at 0, 3,5 minuteswas not significant in both the study groups. Whereas there was
significant reduction in the level of pain and mean cry time in the neonates of sucrose group. Heart rateand oxygen
saturation after intradermal injection also showed significant (p less than 0.001) differenceamong the neonates, who received 24%
of oral sucroseand Facilitated tucking than for neonates of control group. Thus oral (24%)sucrose solution given 2 minutes
before injection was effective in reducing level of neonatal pain following Intradermal Vaccination. It is a simple, safe and
fast acting analgesic and should be considered for minor invasive procedures in term neonates which last for 5-7minutes.
