Microsponges: An Overview

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Hamid Hussain ◽  
Divya Juyal ◽  
Archana Dhyani
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Active Agent ◽  
Topical Delivery ◽  
Water Soluble ◽  
Wide Range ◽  
Porous Beads

Microsponge and Nanosponge delivery System was originally developed for topical delivery of drugs can also be used for controlled oral delivery of drugs using water soluble and bioerodible polymers. Microsponge delivery system (MDS) can entrap wide range of drugs and then release them onto the skin over a time by difussion mechanism to the skin. It is a unique technology for the controlled release of topical agents and consists of nano or micro porous beads loaded with active agent and also use for oral delivery of drugs using bioerodible polymers.

scholarly journals Fabrication of PLA-PEG Nanoparticles as Delivery Systems for Improved Stability and Controlled Release of Catechin

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Neha Atulkumar Singh ◽  
Abul Kalam Azad Mandal ◽  
Zaved Ahmed Khan
Keyword(s):  
Controlled Release ◽  
Delivery System ◽  
Oral Delivery ◽  
Polymeric Nanoparticles ◽  
Double Emulsion ◽  
Hydrodynamic Diameter ◽  
Sem Image ◽  
Oral Delivery System ◽  
Improved Stability

The purpose of this study was to develop an oral delivery system for the controlled release of catechin and evaluate the antioxidant potential and stability of catechin loaded PLA/PEG nanoparticles (CATNP). Nanoparticles were synthesized using a double emulsion solvent evaporation method. The fabricated nanoparticles were relatively small with a hydrodynamic diameter of 300 nm and an encapsulation efficiency of 95%. SEM image analysis showed uniform sized and spherically shaped nanoparticles. In vitro release profiles indicated a slow and sustained release of catechin from the nanoparticle. Stability of the nanoparticle in simulated gastric and intestinal fluids is maintained due to the PEG coating on the nanoparticles, which effectively protected catechin against gastrointestinal enzyme activity. Enhanced inhibition action of free radicals and metal chelation potential was noted when catechin was encapsulated in these polymeric nanoparticles. The reports obtained from this study would provide an opportunity for designing an oral delivery system aimed at inhibiting oxidative stress in the human body.

A Poly(β-Amino Ester) of Spermine and Poly(ethylene Glycol) Diacrylate as a Gene Carrier

2007 ◽  
Vol 342-343 ◽  
pp. 425-428 ◽  
Author(s):  
Dhananjay Jere ◽  
Tae Hee Kim ◽  
Rohidas B. Arote ◽  
Hu Lin Jiang ◽  
Myung Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Water Soluble ◽  
Gene Carrier ◽  
Gene Delivery System ◽  
Poly Ethylene Glycol ◽  
Wide Range ◽  
Poly Ethylene

Vectors are vital aspect of gene delivery system which decides the success of gene therapy. Efficient transfection with minimum or no toxicity, are two principal aims of any gene delivery system. In this our study, we rationally developed biodegradable water soluble poly(ßamino ester) (PAE) based on spermine (SPR) and poly (ethylene glycol) (PEG), by Michael-type addition reaction and further studied for its potential as a gene carrier. Confirmation of synthesized PAE was done by proton NMR spectroscopy. In gel retardation assay, the PAEs have shown good DNA binding ability over wide range of polyplexes. The addition of PEG over SPR resulted in a novel PAE with higher degree of safety and transfection efficiency as compared with polyethylenimine 25K (PEI) when studied in 293T human kidney carcinoma cells.

Controlled release of cyclosporin A from liposomes-in-microspheres as an oral delivery system

2006 ◽  
Vol 11 (6) ◽  
pp. 526-529 ◽  
Author(s):  
Hee-Jung Park ◽  
Chang-Moon Lee ◽  
Yong-Bok Lee ◽  
Ki-Young Lee
Keyword(s):  
Controlled Release ◽  
Cyclosporin A ◽  
Delivery System ◽  
Oral Delivery ◽  
Oral Delivery System

Investigation of Nanoscale Structure of Self-Emulsifying Drug Delivery System Containing Poorly Water-Soluble Model Drug

2014 ◽  
Vol 970 ◽  
pp. 272-278 ◽  
Author(s):  
Mont Kumpugdee-Vollrath ◽  
Yotsanan Weerapol ◽  
Karin Schrader ◽  
Pornsak Sriamornsak
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Correlation Spectroscopy ◽  
Water Soluble ◽  
Wide Range ◽  
Poorly Water Soluble ◽  
Nanoscale Structure ◽  
Model Drug ◽  
20 Nm

This work has a focus on the self-emulsifying drug delivery system (SEDDS), which can be used in pharmaceutical field for increasing bioavailability of poorly water-soluble drugs. The model drug resveratrol was used because of its poor water-solubility and is of interest because of its wide range of pharmacological effects. It is beneficial to understand the mechanism of SEDDS formation in the human body, therefore, the determination of nanoscale structure was carried out. For this purpose, small angle X-ray scattering (SAXS), photon correlation spectroscopy (PCS), and transmission electron microscopy (TEM) techniques were applied. We have found that the size and size distribution of particles were in nanometers. The inner structure of SEDDS was ordered with the lamellar distances (d-spacing) of < 20 nm. It seems that the prepared SEDDS in water form large oil drops (200-400 nm) in water as well as small micelles with the droplet size of 10-20 nm.

Recent Advances in Nanosponges as Drug Delivery System

2013 ◽  
Vol 6 (1) ◽  
pp. 1934-1944 ◽  
Author(s):  
Uday B Bolmal ◽  
F V Manvi ◽  
Rajkumar Kotha ◽  
Sai Sowjanya Palla ◽  
Anusha Paladugu ◽  
...  
Keyword(s):  
Delivery System ◽  
Oral Delivery ◽  
Aqueous Solubility ◽  
The Body ◽  
Target Site ◽  
Water Soluble ◽  
Specific Target ◽  
Poor Solubility ◽  
Water Soluble Drugs ◽  
Important Character

Major problem of many newly developed chemical entities is their poor solubility in water and pharmacokinetic issues. These poorly-water soluble drugs show many problems in formulating them in conventional dosage forms and the critical problem associated is its very low bio-availability. Nanotechnology has attracted increasing attention during recent years and it can resolve the problems associated with solubility and bio-availability. Nanosponges are a part of nanotechnology. Nanosponges delivery system, which was originally developed for topical delivery of drugs, can also be used for controlled oral delivery of drugs using water soluble and bioerodible polymers. Nanosponges are tiny sponges with a size of about a virus, which can be filled with wide variety of drugs. These tiny sponges can circulate around the body until they encounter the specific target site and stick on the surface and begin to release the drug in a controlled and predictable manner. Because the drug can be released at the specific target site instead of circulating throughout the body it will be more effective for specific disease targeted treatment. Another important character of these sponges is their aqueous solubility; this allows the use of these systems effectively for drugs with poor solubility. 

Sign in / Sign up

Export Citation Format

Share Document