Investigation of Functionalized Poly(N ,N -dimethylacrylamide)-block -polystyrene Nanoparticles As Novel Drug Delivery System to Overcome the Blood-Brain Barrier In Vitro

2015 ◽  
Vol 15 (12) ◽  
pp. 1687-1697 ◽  
Author(s):  
Maria Gregori ◽  
Daniela Bertani ◽  
Emanuela Cazzaniga ◽  
Antonina Orlando ◽  
Michele Mauri ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Brain Barrier ◽  
Polystyrene Nanoparticles ◽  
Blood Brain ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals LRP1-mediated pH-sensitive polymersomes facilitate combination therapy of glioblastoma in vitro and in vivo

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Chen He ◽  
Zhiyuan Zhang ◽  
Yinan Ding ◽  
Kangli Xue ◽  
Xihui Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Ph Sensitive ◽  
Brain Barrier ◽  
Blood Brain ◽  
Good Ability ◽  
Complex Drug

Abstract Background Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment is one of the most daunting challenges in oncology. The blood–brain barrier (BBB) is the main obstacle that prevents the delivery of potentially active therapeutic compounds. In this study, a new type of pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve a combination of radiotherapy and chemotherapy for U87-MG human glioblastoma xenografts in nude mice and significantly increased survival time. Results The Au-DOX@PO-ANG has a good ability to cross the blood–brain barrier and target tumors. This delivery system has pH-sensitivity and the ability to respond to the tumor microenvironment. Gold nanoparticles and doxorubicin are designed as a complex drug. This type of complex drug improve the radiotherapy (RT) effect of glioblastoma. The mice treated with Au-DOX@PO-ANG NPs have a significant reduction in tumor volume. Conclusion In summary, a new pH-sensitive drug delivery system was fabricated for the treatment of glioblastoma. The new BBB-traversing drug delivery system potentially represents a novel approach to improve the effects of the treatment of intracranial tumors and provides hope for glioblastoma treatment.

scholarly journals LRP1-mediated pH-sensitive Polymersomes Facilitate Combination Therapy of Glioblastoma in Vitro and in Vivo

2020 ◽  
Author(s):  
Chen He ◽  
Zhiyuan Zhang ◽  
Yinan Ding ◽  
Kangli Xue ◽  
Xihui Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Ph Sensitive ◽  
Brain Barrier ◽  
Blood Brain ◽  
Good Ability ◽  
Complex Drug

Abstract Background: Glioblastoma (GBM) is the most invasive primary intracranial tumor, and its effective treatment is one of the most daunting challenges in oncology. The blood-brain barrier (BBB) is the main obstacle that prevents the delivery of potentially active therapeutic compounds. In this study, a new type of pH-sensitive polymersomes has been designed for glioblastoma therapy to achieve a combination of radiotherapy and chemotherapy for U87-MG human glioblastoma xenografts in nude mice and significantly increased survival time.Results: The Au-DOX@PO-ANG has a good ability to cross the blood-brain barrier and target tumors. This delivery system has pH-sensitivity and the ability to respond to the tumor microenvironment. Gold nanoparticles and doxorubicin are designed as a complex drug. This type of complex drug improve the radiotherapy (RT) effect of glioblastoma. The mice treated with Au-DOX@PO-ANG NPs have a significant reduction in tumor volume.Conclusion: In summary, a new pH-sensitive drug delivery system was fabricated for the treatment of glioblastoma. The new BBB-traversing drug delivery system potentially represents a novel approach to improve the effects of the treatment of intracranial tumors and provides hope for glioblastoma treatment.

Efficacy of Dual-Targeting Combined Anti-Tuberculosis Drug Delivery System in the Treatment of Tuberculous Meningitis

2021 ◽  
Vol 17 (10) ◽  
pp. 2034-2042
Author(s):  
Wenjing Ma ◽  
Huan Peng ◽  
Kewei Liu ◽  
Yaguo Wang ◽  
Wei Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mycobacterium Tuberculosis ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Tuberculous Meningitis ◽  
Targeted Drug Delivery ◽  
Brain Barrier ◽  
Blood Brain ◽  
Targeted Drug

Tuberculous meningitis (TBM) is an incurable disease with high mortality. It is an extrapulmonary tuberculosis caused by mycobacterium tuberculosis which penetrated the blood-brain barrier and infected the meninges. Mycobacterium tuberculosis lurking in the body mainly reside in macrophages. Anti-tuberculous drugs usually can not target the blood-brain barrier and macrophages, the drug concentration in the lesion is low, which cannot effectively kill mycobacterium tuberculosis, making TBM difficult to treat. Targeted drug delivery systems can target drugs to specific nidus. In the study, we constructed a drug delivery system, which was a cell penetrate peptide B6 and phosphatidylserine (PS) modified polyethylene glycol (PEG) nanomaterial to target the blood-brain barrier and to target macrophages. This nanomaterial was a combined anti-tuberculosis drug delivery system encapsulating antituberculosis drugs rifampicin and pyrazinamide, designed to target macrophages in the brain and kill mycobacterium tuberculosis lurking in the macrophages. We have physically characterized the drug delivery system, and verified the bactericidal ability at cellular and animal level. Results have shown that the targeted drug delivery system had a remarkable efficacy to treat TBM in mice.

scholarly journals Nanomiemgel - A Novel Drug Delivery System for Topical Application - In Vitro and In Vivo Evaluation

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e115952 ◽  
Author(s):  
Jaganmohan Somagoni ◽  
Cedar H. A. Boakye ◽  
Chandraiah Godugu ◽  
Apurva R. Patel ◽  
Henrique Antonio Mendonca Faria ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Topical Application ◽  
In Vivo Evaluation ◽  
Novel Drug Delivery System ◽  
Novel Drug

scholarly journals Penetration of the blood–brain barrier and the anti-tumour effect of a novel PLGA-lysoGM1/DOX micelle drug delivery system

Nanoscale ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 2946-2960 ◽  
Author(s):  
Ying Yin ◽  
Jun Wang ◽  
Meng Yang ◽  
Ruolin Du ◽  
Giuseppe Pontrelli ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Brain Barrier ◽  
Blood Brain ◽  
System P ◽  
Anti Tumour Effect

a) Diagram depicting the preparation of drug delivery system of PLGA-lysoGM1/DOX micelles. b) Schematic illustration of micelles elicited antitumor. c) Micelles cross BBB via micropinocytosis and autophagy/lysosomal pathways.

scholarly journals Innovative approach for nasal drug delivery system for brain target

2021 ◽  
Vol 9 (3) ◽  
pp. 093-106
Author(s):  
Priyadarshani G Patil ◽  
Sampada V Marodkar ◽  
Sachin J Dighade ◽  
Prajakta N Dongare ◽  
Bhagyashri A Borade
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Blood Brain Barrier ◽  
Delivery System ◽  
Drug Transport ◽  
Nasal Delivery ◽  
Brain Barrier ◽  
Non Invasive ◽  
Brain Drug Delivery ◽  
Blood Brain

The goal of brain drug targeting technology is the delivery of therapeutics across the blood brain barrier (BBB), including the human BBB. Nose to brain drug delivery has received a great deal of attention as a non- invasive, convenient and reliable drug delivery system. For the systemic and targetedadministration of drug. The various drug deliveries through some drug transport pathways, Factor influencing nasal drug absorption, formulation strategies nose to brain, colloidal carriers in nose to brain drug delivery system and nasal delivery systems. Physiological barriers (BBB) that restricts the delivery of drug to CNS. Thus intranasal route has attracted a wide attention of convenient, non-invasive, reliable, and safe route to achieve faster and higher level of drug in the brain through olfactory region by passing blood brain barrier. Intranasal administration rapid onset of action, no first –pass effect , no gastrointestinal degradation lungs toxicity and non-invasiveness application and also improves bioavailability.

Development and In Vitro Evaluation of a Novel Drug Delivery System (Albumin Microspheres Containing Liposomes) Applied to Vancomycin

2016 ◽  
Vol 105 (7) ◽  
pp. 2180-2187 ◽  
Author(s):  
María José de Jesús Valle ◽  
David López Díaz ◽  
Mercedes Velázquez Salicio ◽  
Amparo Sánchez Navarro
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Evaluation ◽  
Albumin Microspheres ◽  
Novel Drug Delivery System ◽  
Novel Drug
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