Multiple acquisitions with global inversion cycling (MAGIC): A multislice technique for vascular-space-occupancy dependent fMRI

2003 ◽  
Vol 51 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Hanzhang Lu ◽  
Peter C.M. van Zijl ◽  
Jeroen Hendrikse ◽  
Xavier Golay
Keyword(s):  
Vascular Space ◽  
Multislice Technique

The Morphology of Vacuolated Cells in the Liver Following Administration of Vitamin A.

1973 ◽  
Vol 31 ◽  
pp. 408-409
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Vitamin A ◽  
Light And Electron Microscopy ◽  
Liver Cells ◽  
Prominent Feature ◽  
Vascular Space ◽  
Vacuolated Cell ◽  
Vacuolated Cells ◽  
Vacuolated Cytoplasm

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).

The Added Value of Inflow-Based Vascular-Space-Occupancy and Diffusion-Weighted Imaging in Preoperative Grading of Gliomas

2021 ◽  
pp. 1-8
Author(s):  
Haimei Cao ◽  
Xiang Xiao ◽  
Jun Hua ◽  
Guanglong Huang ◽  
Wenle He ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Roc Curve ◽  
Diffusion Weighted Imaging ◽  
Low Grade ◽  
High Grade ◽  
Mr Images ◽  
Vascular Space ◽  
Diffusion Weighted ◽  
High Grade Gliomas ◽  
And Diffusion

Objectives: The present study aimed to study whether combined inflow-based vascular-space-occupancy (iVASO) MR imaging (MRI) and diffusion-weighted imaging (DWI) improve the diagnostic accuracy in the preoperative grading of gliomas. Methods: Fifty-one patients with histopathologically confirmed diffuse gliomas underwent preoperative structural MRI, iVASO, and DWI. We performed 2 qualitative consensus reviews: (1) structural MR images alone and (2) structural MR images with iVASO and DWI. Relative arteriolar cerebral blood volume (rCBVa) and minimum apparent diffusion coefficient (mADC) were compared between low-grade and high-grade gliomas. Receiver operating characteristic (ROC) curve analysis was performed to compare the tumor grading efficiency of rCBVa, mADC, and the combination of the two parameters. Results: Two observers diagnosed accurate tumor grade in 40 of 51 (78.4%) patients in the first review and in 46 of 51 (90.2%) in the second review. Both rCBVa and mADC showed significant differences between low-grade and high-grade gliomas. ROC analysis gave a threshold value of 1.52 for rCBVa and 0.85 × 10−3 mm2/s for mADC to provide a sensitivity and specificity of 88.0 and 81.2% and 100.0 and 68.7%, respectively. The area under the ROC curve (AUC) was 0.87 and 0.85 for rCBVa and mADC, respectively. The combination of rCBVa and mADC values increased the AUC to 0.92. Conclusion: The combined application of iVASO and DWI may improve the diagnostic accuracy of glioma grading.

scholarly journals 37 Quantitative evaluation of lymph-vascular space invasion (LVSI) in patients affected by endometrial cancer: prognostic and clinical implications

2020 ◽  
Author(s):  
S Restaino ◽  
L Tortorella ◽  
E Perrone ◽  
G Monterossi ◽  
A Gioè ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Quantitative Evaluation ◽  
Clinical Implications ◽  
Vascular Space ◽  
Vascular Space Invasion

Conservative Surgical Treatment in Cervical Cancer with 3 to 5 mm Stromal Invasion in the Absence of Confluent invasion and Lymph-Vascular Space Involvement

1994 ◽  
Vol 54 (3) ◽  
pp. 333-337 ◽  
Author(s):  
Nobuo Yaegashi ◽  
Shinji Sato ◽  
Yoshiki Inoue ◽  
Kiichiro Noda ◽  
Akira Yajima
Keyword(s):  
Cervical Cancer ◽  
Surgical Treatment ◽  
Stromal Invasion ◽  
Vascular Space

scholarly journals On the measurement of absolute cerebral blood volume (CBV) using vascular-space-occupancy (VASO) MRI

2008 ◽  
Vol 61 (3) ◽  
pp. 659-667 ◽  
Author(s):  
Jinsoo Uh ◽  
Kelly Lewis-Amezcua ◽  
Rani Varghese ◽  
Hanzhang Lu
Keyword(s):  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Vascular Space

scholarly journals Prognostic parameters in FIGO stage I endometrial carcinoma of endometrioid type

2006 ◽  
Vol 63 (12) ◽  
pp. 1006-1010 ◽  
Author(s):  
Zorica Stanojevic ◽  
Biljana Djordjevic
Keyword(s):  
Endometrial Carcinoma ◽  
Myometrial Invasion ◽  
Figo Stage ◽  
Histologic Grade ◽  
Stage I ◽  
Prognostic Parameters ◽  
Vascular Space ◽  
Vascular Space Invasion ◽  
Pathologic Parameters

Background/Aim. Endometrial carcinoma is the most common malignant neoplasm of the female genital tract in developed countries. Endometrioid carcinoma represents about three-fourths of all endometrial carcinoma. The aim of this study was to examine pathologic parameters, age, and the 5-year survival of the patients with FIGO stage I endometrial carcinoma of endometrioid type and to assess the prognostic utility of age, depth of myometrial invasion, hystologic type (endometrioid or variant), histologic grade, nuclear grade, and lymph-vascular space invasion. Methods. Age, pathologic parameters, and survival data were retrospectively collected on 236 patients with FIGO stage I endometrial carcinoma of endometrioid type. All the patients underwent hysterectomy between 1996 and 2000 and follow-up until December 2005. Results. A total of 236 patients (mean age 58.0, range 40?79) were analyzed. During the 5-year period of follow-up, 59 (25.0%) patents died from the disease. An univariate analysis revealed that age, depth of myometrial invasion, histologic grade, nuclear grade, and lymph-vascular space invasion were associated significantly with the 5-year survival of the patients. A multivariate analysis revealed that age, lymph-vascular space invasion, and depth of myometrial invasion were associated significantly with the 5-year survival. Conclusion. Age, lymph-vascular space invasion, and depth of myometrial invasion are independent prognostic parameters for the 5-year survival of the patients with FIGO stage I endometrial carcinoma of endometrioid type.

scholarly journals Substantial lymph-vascular space invasion (LVSI) as predictor of distant relapse and poor prognosis in low-risk early-stage endometrial cancer

2021 ◽  
Vol 32 (2) ◽  
Author(s):  
Lucia Tortorella ◽  
Stefano Restaino ◽  
Gian Franco Zannoni ◽  
Giuseppe Vizzielli ◽  
Vito Chiantera ◽  
...  
Keyword(s):  
Endometrial Cancer ◽  
Poor Prognosis ◽  
Early Stage ◽  
Low Risk ◽  
Distant Relapse ◽  
Vascular Space ◽  
Early Stage Endometrial Cancer ◽  
Vascular Space Invasion

An immediate endothelial cell signaling response to lung ischemia

2001 ◽  
Vol 281 (4) ◽  
pp. L993-L1000 ◽  
Author(s):  
Chun Song ◽  
Abu B. Al-Mehdi ◽  
Aron B. Fisher
Keyword(s):  
Endothelial Cells ◽  
Shear Stress ◽  
Initial Response ◽  
Membrane Depolarization ◽  
Initial Increase ◽  
Amplex Red ◽  
Vascular Space ◽  
Endothelial Response ◽  
Intracellular Ca

Abrupt cessation of lung perfusion induces a rapid endothelial response that is not associated with anoxia but reflects loss of normal shear stress. This response includes membrane depolarization, H2O2generation, and increased intracellular Ca2+. We evaluated these parameters immediately upon nonhypoxic ischemia using fluorescence videomicroscopy to image in situ endothelial cells in isolated, ventilated rat lungs. Lungs labeled with 4-{2-[6-(dioctylamino)-2-naphthalenyl]ethenyl}1-(3-sulfopropyl)-pyridinium (di-8-ANEPPS; a membrane potential probe), Amplex Red (an extracellular H2O2probe), or fluo 3-AM (a Ca2+indicator) were subjected to control perfusion followed by global ischemia. Endothelial di-8-ANEPPS fluorescence increased significantly within the first second of ischemia and stabilized at 15 s, indicating membrane depolarization by ∼17 mV; depolarization was blocked by preperfusion with the K+channel agonist lemakalim. Increased H2O2, inhibitable by catalase, was detected in the vascular space at 1–2 s after the onset of ischemia. Increased intracellular Ca2+was detected 10–15 s after the onset of ischemia; the initial increase was inhibited by preperfusion with thapsigargin. Thus the temporal sequence of the initial response of endothelial cells in situ to loss of shear stress (i.e., ischemia) is as follows: membrane depolarization, H2O2release, and increased intracellular Ca2+.

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