scholarly journals High normal post-load plasma glucose, cardiometabolic risk factors and signs of organ damage in obese children

Obesity ◽  
2014 ◽  
Vol 22 (8) ◽  
pp. 1860-1864 ◽  
Author(s):  
Procolo Di Bonito ◽  
Maria Rosaria Licenziati ◽  
Marco Giorgio Baroni ◽  
Tiziana Congiu ◽  
Michela Incani ◽  
...  
Keyword(s):  
Risk Factors ◽  
Plasma Glucose ◽  
Cardiometabolic Risk ◽  
Organ Damage ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

Bisphenol A and cardiometabolic risk factors in obese children

2014 ◽  
Vol 470-471 ◽  
pp. 726-732 ◽  
Author(s):  
Naila Khalil ◽  
James R. Ebert ◽  
Lei Wang ◽  
Scott Belcher ◽  
Miryoung Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bisphenol A ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

Cardiometabolic risk factors, adipokine imbalance and target organ damage in women after hypertensive disorders during pregnancy

2019 ◽  
Vol 17 ◽  
pp. S10
Author(s):  
Vasilii Chulkov ◽  
Olesya Tarasova ◽  
Natalya Vereina ◽  
Vladislav Chulkov ◽  
Sergei Sinitsin
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Cardiometabolic Risk Factors ◽  
Hypertensive Disorders

scholarly journals Association between Circulating Osteocalcin and Cardiometabolic Risk Factors following a 4-Week Leafy Green Vitamin K-Rich Diet

2020 ◽  
Vol 76 (5) ◽  
pp. 361-367
Author(s):  
Alexander Tacey ◽  
Marc Sim ◽  
Cassandra Smith ◽  
Mary N. Woessner ◽  
Elizabeth Byrnes ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Arterial Stiffness ◽  
Plasma Glucose ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Cardiometabolic Health ◽  
Vitamin K1 ◽  
Low Responders ◽  
High Responders

<b><i>Background:</i></b> Evidence suggests that lower serum undercarboxylated osteocalcin (ucOC) may be negatively associated with cardiometabolic health. We investigated whether individuals with a suppression of ucOC following an increase in dietary vitamin K1 exhibit a relative worsening of cardiometabolic risk factors. <b><i>Materials and Methods:</i></b> Men (<i>n</i> = 20) and women (<i>n</i> = 10) aged 62 ± 10 years participated in a randomized, controlled, crossover study. The primary analysis involved using data obtained from participants following a high vitamin K1 diet (HK; 4-week intervention of increased leafy green vegetable intake). High and low responders were defined based on the median percent reduction (30%) in ucOC following the HK diet. Blood pressure (resting and 24 h), arterial stiffness, plasma glucose, lipid concentrations, and serum OC forms were assessed. <b><i>Results:</i></b> Following the HK diet, ucOC and ucOC/tOC were suppressed more (<i>p</i> &#x3c; 0.01) in high responders (41 and 29%) versus low responders (12 and 10%). The reduction in ucOC and ucOC/tOC was not associated with changes in blood pressure, arterial stiffness, plasma glucose, or lipid concentrations in the high responders (<i>p</i> &#x3e; 0.05). <b><i>Discussion/Conclusion:</i></b> Suppression of ucOC via consumption of leafy green vegetables has no negative effects on cardiometabolic health, perhaps, in part, because of cross-talk mechanisms.

scholarly journals Fasting Plasma Glucose and Clustering of Cardiometabolic Risk Factors in Normoglycemic Outpatient Children and Adolescents

Diabetes Care ◽  
2011 ◽  
Vol 34 (6) ◽  
pp. 1412-1414 ◽  
Author(s):  
P. Di Bonito ◽  
E. Sanguigno ◽  
C. Forziato ◽  
F. Saitta ◽  
M. R. Iardino ◽  
...  
Keyword(s):  
Risk Factors ◽  
Children And Adolescents ◽  
Plasma Glucose ◽  
Fasting Plasma Glucose ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Fasting Plasma ◽  
Outpatient Children

URIC ACID IS ASSOCIATED WITH CARDIOMETABOLIC RISK FACTORS IN OVERWEIGHT AND OBESE CHILDREN AND ADOLESCENTS

2018 ◽  
Vol 36 (Supplement 1) ◽  
pp. e18
Author(s):  
J. Alvarez ◽  
P. Redon ◽  
M. Torro ◽  
F. Aguilar ◽  
J. Redon ◽  
...  
Keyword(s):  
Risk Factors ◽  
Uric Acid ◽  
Children And Adolescents ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

scholarly journals O-052 25-hydroxy Vit D, Adiponectin Levels And Cardiometabolic Risk Factors In A Sample Of Obese Children

2014 ◽  
Vol 99 (Suppl 2) ◽  
pp. A41.3-A42
Author(s):  
S El-Masry ◽  
NE Hassan ◽  
RA El Banna ◽  
ER Abdel-Hamid ◽  
M Al-Tohamy
Keyword(s):  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Cardiometabolic Risk Factors ◽  
Obese Children

Concentrations of leptin, adiponectin and other metabolic parameters in non-obese children with Down syndrome

2017 ◽  
Vol 30 (8) ◽  
Author(s):  
Nikhil Tenneti ◽  
Devi Dayal ◽  
Sheetal Sharda ◽  
Inusha Panigrahi ◽  
Mohammed Didi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Down Syndrome ◽  
Cardiometabolic Risk ◽  
Fasting Glucose ◽  
Cardiometabolic Risk Factors ◽  
Morbidity And Mortality ◽  
Leptin Resistance ◽  
P Value ◽  
Obese Children ◽  
Lipid Parameters

AbstractBackground:Recent data indicates that adults with Down syndrome (DS) are at increased risk for cardiovascular disease (CVD) that significantly contributes to their morbidity and mortality. Although identification of cardiometabolic risk factors during childhood is desirable to design preventive interventions, the data on such risk factors in children with DS is scarce. The aim of this study was to study the cardiometabolic risk factors such as insulin resistance (IR), leptin and adiponectin concentrations, lipid abnormalities and leptin resistance in non-obese children with DS.Methods:This cross-sectional case control study included karyotype confirmed trisomy-21 DS children aged 2–12 years and their matched healthy controls. After detailed anthropometry, weight, height and body mass index (BMI) standard deviation scores (SDSs) were calculated with reference data. Laboratory evaluation included determination of fasting lipid parameters, insulin, glucose, leptin and adiponectin concentrations. The homeostasis model assessment method (HOMA-IR) was used to assess IR and the ratio of leptin to BMI was used as an index of leptin resistance.Results:Seventy-seven children (39 with DS and 38 controls) comprised the study cohort. The anthropometric parameters were similar in the two groups. Children with DS showed significantly higher mean leptin concentrations (2.098±1.68 ng/mL vs. 1.44±0.52 ng/mL, p-value: 0.00) and higher indices of leptin resistance (0.127±0.085 vs. 0.09±0.03, p-value: 0.001) as compared to controls. Fasting adiponectin concentrations were lower (20.64±19.87 ng/mL vs. 32.58±34.25 ng/mL, p-value: 0.21) and fasting glucose higher (89.25±8.12 mg/dL vs. 85.71±5.52 mg/dL, p-value: 0.06) in the DS group as compared to the controls but the differences did not reach statistical significance. The concentrations of insulin, various lipid parameters and calculated HOMA-IR values were similar in the two groups. In the DS group, five children were identified to have high (>75th centile) leptin levels and four as impaired fasting glucose as compared to none in the controls.Conclusions:Alterations of several cardiometabolic risk factors, in particular, leptin concentrations and leptin resistance are present in children with DS. The presence of hyperleptinemia without hyperinsulinemia suggests a probable inherent genetic basis for increased leptin resistance in patients with DS. There is a need for larger studies to further understand increased leptin resistance in DS that may contribute to increased CVD related morbidity and mortality in these patients.

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