scholarly journals Loss of Uncoupling Protein 3 Attenuates Western Diet–Induced Obesity, Systemic Inflammation, and Insulin Resistance in Rats

Obesity ◽  
2020 ◽  
Vol 28 (9) ◽  
pp. 1687-1697
Author(s):  
Tyler M. Lomax ◽  
Sadia Ashraf ◽  
Gizem Yilmaz ◽  
Romain Harmancey
Keyword(s):  
Insulin Resistance ◽  
Systemic Inflammation ◽  
Uncoupling Protein ◽  
Western Diet ◽  
Diet Induced Obesity ◽  
Uncoupling Protein 3

Lack of Uncoupling Protein 3 Protects from High‐Fat Diet‐Induced Obesity, Systemic Inflammation and Insulin Resistance in Rats

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Tyler Lomax ◽  
Sadia Ashraf ◽  
Gizem Yilmaz ◽  
Romain Harmancey
Keyword(s):  
Insulin Resistance ◽  
Systemic Inflammation ◽  
High Fat Diet ◽  
Uncoupling Protein ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Uncoupling Protein 3

scholarly journals Exposure to the Widely Used Pyrethroid Pesticide Deltamethrin, Does Not Exacerbate High Fat Diet Induced Obesity or Insulin Resistance in C57BL/6J Mice

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A45-A46
Author(s):  
Evangelia Evelyn Tsakiridis ◽  
Marisa Morrow ◽  
Andrea Llanos ◽  
Bo Wang ◽  
Alison Holloway ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glycemic Control ◽  
Metabolic Diseases ◽  
Uncoupling Protein ◽  
Diet Induced Obesity ◽  
Brown Adipose ◽  
Pyrethroid Pesticide ◽  
First Time

Abstract Deltamethrin is a commonly used pesticide for the control of mosquito populations. Despite widespread use, the effects of deltamethrin on adiposity and glucose homeostasis have been equivocal with some studies showing increased, decreased and no effect on adiposity and glycemic control. However, no study to date has investigated the effect of deltamethrin in mice housed at thermoneutral temperatures, which is important for modelling metabolic diseases in rodents due to reduced thermal stress and constitutive activation of brown adipose tissue. In the current study we demonstrate for the first time that deltamethrin reduces uncoupling protein-1 expression in brown adipocytes cultured in vitro at concentrations as low as 1pm. Meanwhile, in-vivo deltamethrin does not appear to alter glycemic control or promote adiposity at exposures equivalent to 0.01, 0.1 or 1.0 mg/kg/day. Together, our study demonstrates environmentally relevant exposure to deltamethrin does not exacerbate diet induced obesity or insulin resistance.

scholarly journals Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

2007 ◽  
Vol 117 (7) ◽  
pp. 1995-2003 ◽  
Author(s):  
Cheol Soo Choi ◽  
Jonathan J. Fillmore ◽  
Jason K. Kim ◽  
Zhen-Xiang Liu ◽  
Sheene Kim ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Uncoupling Protein ◽  
Uncoupling Protein 3

scholarly journals Reduction of diet-induced obesity in transgenic mice overexpressing uncoupling protein 3 in skeletal muscle

Diabetologia ◽  
2004 ◽  
Vol 47 (1) ◽  
pp. 47-54 ◽  
Author(s):  
C. Son ◽  
K. Hosoda ◽  
K. Ishihara ◽  
L. Bevilacqua ◽  
H. Masuzaki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Transgenic Mice ◽  
Uncoupling Protein ◽  
Diet Induced Obesity ◽  
Uncoupling Protein 3

scholarly journals Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism

2016 ◽  
Vol 30 (5) ◽  
pp. 533-542 ◽  
Author(s):  
Li Mo ◽  
Jing Shen ◽  
Qinhui Liu ◽  
Yuwei Zhang ◽  
Jiangying Kuang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Uncoupling Protein ◽  
Constitutive Androstane Receptor ◽  
Physiological Role ◽  
Glucose And Lipid Metabolism ◽  
Diet Induced Obesity ◽  
Fibronectin Type Iii ◽  
Glucose And Lipid Homeostasis ◽  
Fibronectin Type Iii Domain ◽  
Amp Activated Protein Kinase

Abstract Irisin, a hormone proteolytically processed from fibronectin type III domain-containing protein 5 (FNDC5), has been reported to induce the browning of sc adipocytes by increasing the level of uncoupling protein 1. In this study, we showed that activation of the nuclear receptor constitutive androstane receptor induced FNDC5 mRNA expression in the liver and increased the circulating level of irisin in mice. FNDC5/irisin is a direct transcriptional target of constitutive androstane receptor. Hepatic-released irisin functioned as a paracrine/autocrine factor that inhibited lipogenesis and gluconeogenesis via the Adenosine 5′-monophosphate (AMP)-activated protein kinase pathway. Adenovirus-overexpressed irisin improved hepatic steatosis and insulin resistance in genetic-induced obese mice. Irisin transgenic mice were also protected against high-fat diet-induced obesity and insulin resistance. In conclusion, our results reveal a novel pathway in regulating FNDC5/irisin expression and identify a physiological role for this hepatic hormone in glucose and lipid homeostasis.

NO-1886 (ibrolipim), a lipoprotein lipase activator, increases the expression of uncoupling protein 3 in skeletal muscle and suppresses fat accumulation in high-fat diet–induced obesity in rats

Metabolism ◽  
2005 ◽  
Vol 54 (12) ◽  
pp. 1587-1592 ◽  
Author(s):  
Masataka Kusunoki ◽  
Kazuhiko Tsutsumi ◽  
Koshi Iwata ◽  
Weidong Yin ◽  
Takao Nakamura ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Lipoprotein Lipase ◽  
High Fat Diet ◽  
Uncoupling Protein ◽  
High Fat ◽  
Fat Accumulation ◽  
Diet Induced Obesity ◽  
Uncoupling Protein 3

scholarly journals Acute inflammation is a predisposing factor for weight gain and insulin resistance

2019 ◽  
Author(s):  
Edson M. de Oliveira ◽  
Jacqueline C. Silva ◽  
Thais P. Ascar ◽  
Silvana Sandri ◽  
Alexandre F. Marchi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Weight Gain ◽  
Inflammatory Markers ◽  
Western Diet ◽  
List Type ◽  
Predisposing Factor ◽  
Amyloid A ◽  
Diet Induced Obesity

ABSTRACTAimIntense endotoxaemia and infection are able to reduce appetite and induce a catabolic state, therefore leading to weight loss. However, it is underexplored its late effects on energy homeostasis, regulation of body weight and glucose metabolism. Here we addressed whether serial intense endotoxaemia, characterized by an acute phase response and weight loss, could be an aggravating or predisposing factor to diet-induced obesity (DIO) and associated metabolic impairments.MethodsMale Swiss Webster mice were submitted to 8 consecutive doses of lipopolysaccharide (LPS - 10 mg/kg), followed by 10 weeks in high-fat diet (HFD).ResultsAfter the end of the acute endotoxaemia period, mice under chow diet recovered their weight rapidly, within one-week recovery period, which remained similar to its control counterparts. However, acute endotoxaemia caused a long-lasting adipose tissue expression of the inflammatory markers TLR-4, CD14 and serum amyloid A (SAA) and, when challenged by a HFD, LPS-treated mice gained more weight, showed increased fat depots, leptin and insulin levels, and also impaired insulin sensitivity.ConclusionsLPS-treated mice showed a higher susceptibility to the harmful effects of a subsequent HFD. Conditions leading to intense and recurrent endotoxaemia, such as common childhood bacterial infections, may resound for a long time and aggravate the effects of a western diet. If confirmed in humans, infections should be considered an additional factor contributing to obesity and type 2 diabetes epidemics and additionally impose more rigorous dietary recommendations for patients in post-infection recovery.Bullet pointsIntense endotoxemia causes a long-lasting increase in the expression of inflammatory markers in adipose tissue.Intense endotoxemia is a predisposing factor to diet-induced obesity and insulin resistance.Infections may contribute to weight gain when associated to a western diet.

scholarly journals UCP3 gene polymorphism and insulin resistance in obese female adolescents

2012 ◽  
Vol 52 (3) ◽  
pp. 152 ◽  
Author(s):  
Dian Eurike ◽  
Harry Freitag Luglio Muhammad ◽  
Rina Susilowati ◽  
Madarina Julia
Keyword(s):  
Insulin Resistance ◽  
Uncoupling Protein ◽  
Cross Sectional Study ◽  
Insulin Concentration ◽  
Female Adolescents ◽  
Cross Sectional ◽  
Obese Female ◽  
Ucp3 Gene ◽  
Uncoupling Protein 3 ◽  
Pcr Rflp

Background A previous study on obese female adolescents inYogyakarta done in the year 2007 suggests that genetic factorsmight influence insulin resistance. One genetic factor that hasbeen associated \\lith insulin resistance in other populations isthe 􀁐55C;T polymorphism in the uncoupling protein 3 (UCP3)gene.Objective To investigate an association between the 􀁐55C;Tpolymorphism in the UCP3 gene and insulin resistance in obesefemale adolescents in Yogyakarta.Methods A total of79 obese female adolescents were enrolled inthis cross􀁐sectional study. Genotyping of the 􀁐 5 SC/T polymorphismin the UCP3 gene was performed by polymerase chain reaction􀁐restriction fragment length polymorphism (PCR􀁐RFLP).Results The TiT homozygous individuals had a higher risk ofinsulin resistance (OR 2.3; 95% CI 0.4 to 14.1), as well as higherfasting insulin concentration and homeostatic model assessmentfor insulin resistance (HOMA􀁐IR) compared to individuals v.ithother genotypes. The T allele carriers also had a higher risk ofinsulin resistance (OR 1.3; 95% CI 0.7 to 2.5), as well as higherfasting insulin concentration and HOMA􀁐 IR compared to Callele carriers. However, none of these results were statisticallysignificant (P > 0.05).Conclusion The TiT genotype and T allele of the UCP3 gene􀁐55CiT polymorphism was not significantly associated increasedrisk of insulin resistance in obese female adolescents in Yogyakarta.[Paediatr lndanes. 2012;52:152-6].

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