Pro-inflammatory chemokine-chemokine receptor interactions within the Ewing sarcoma microenvironment determine CD8+ T-lymphocyte infiltration and affect tumour progression

2010 ◽  
Vol 223 (3) ◽  
pp. 347-357 ◽  
Author(s):  
Dagmar Berghuis ◽  
Susy J Santos ◽  
Hans J Baelde ◽  
Antonie HM Taminiau ◽  
R Maarten Egeler ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Chemokine Receptor ◽  
Ewing Sarcoma ◽  
Tumour Progression ◽  
Lymphocyte Infiltration ◽  
Cd8 T Lymphocyte ◽  
Receptor Interactions

CD8+T-Lymphocyte Infiltration and Apoptosis in Fulminant Epstein-Barr Virus Hepatitis in a Previously Healthy Girl

2000 ◽  
Vol 19 (6) ◽  
pp. 449-454
Author(s):  
Mayumi Koga ◽  
Tomomi Yoshitomi ◽  
Koichi Tanaka ◽  
Yukihiro Inomata ◽  
Tomoyuki Murakami ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Epstein Barr Virus ◽  
Lymphocyte Infiltration ◽  
Virus Hepatitis ◽  
Barr Virus ◽  
Cd8 T Lymphocyte ◽  
Epstein Barr

scholarly journals Overexpression ofGPC6andTMEM132Din Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Athanasios Karapetsas ◽  
Antonis Giannakakis ◽  
Denarda Dangaj ◽  
Evripidis Lanitis ◽  
Spyridon Kynigopoulos ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
T Lymphocyte ◽  
Early Stage ◽  
Mrna Levels ◽  
Lymphocyte Infiltration ◽  
Ovarian Cancer Cell Lines ◽  
Cd8 T Lymphocyte ◽  
Genes Encoding ◽  
Early Stage Ovarian Cancer

Infiltration of cytotoxic T-lymphocytes in ovarian cancer is a favorable prognostic factor. Employing a differential expression approach, we have recently identified a number of genes associated with CD8+ T-cell infiltration in early stage ovarian tumors. In the present study, we validated by qPCR the expression of two genes encoding the transmembrane proteins GPC6 and TMEM132D in a cohort of early stage ovarian cancer patients. The expression of both genes correlated positively with the mRNA levels ofCD8A, a marker of T-lymphocyte infiltration [Pearson coefficient: 0.427 (p=0.0067) and 0.861 (p<0.0001), resp.].GPC6andTMEM132Dexpression was also documented in a variety of ovarian cancer cell lines. Importantly, Kaplan-Meier survival analysis revealed that high mRNA levels of GPC6 and/or TMEM132D correlated significantly with increased overall survival of early stage ovarian cancer patients(p=0.032). Thus,GPC6andTMEM132Dmay serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis, prognosis, and tumor immunobattling.

CD8+ T lymphocyte infiltration of liver sinusoids could lead to nodular regenerative hyperplasia

2000 ◽  
Vol 32 ◽  
pp. 131
Author(s):  
M. Ziol ◽  
D. Mohand ◽  
V. Echlache ◽  
J. Feuillard ◽  
M. Raphael ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Nodular Regenerative Hyperplasia ◽  
Lymphocyte Infiltration ◽  
Liver Sinusoids ◽  
Cd8 T Lymphocyte

Tu1619 WATER AVOIDANCE STRESS PROMOTES MOUSE PANCREATIC CANCER GROWTH AND SUPPRESSES CD8+ T LYMPHOCYTE INFILTRATION IN PANCREAS.

2020 ◽  
Vol 158 (6) ◽  
pp. S-1139
Author(s):  
Shin Nishii ◽  
Yoshikiyo Okada ◽  
Suguru Ito ◽  
Rina Tanemoto ◽  
Akinori Mizoguchi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
T Lymphocyte ◽  
Cancer Growth ◽  
Lymphocyte Infiltration ◽  
Cd8 T Lymphocyte
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