scholarly journals Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer

2013 ◽  
Vol 230 (2) ◽  
pp. 194-204 ◽  
Author(s):  
Yan Jia ◽  
Yunsheng Yang ◽  
Malcolm V Brock ◽  
Qimin Zhan ◽  
James G Herman ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Epigenetic Regulation ◽  
Human Lung ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Human Lung Cancer ◽  
Wnt Signalling Pathway

Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer

2021 ◽  
Author(s):  
Irlanda Peralta-Arrieta ◽  
Octavio A. Trejo-Villegas ◽  
Leonel Armas-López ◽  
Hugo A. Ceja-Rangel ◽  
María del Carmen Ordóñez-Luna ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Epigenetic Regulation ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Egfr Tki

Epigenetic regulation in the Wnt signalling pathway

2008 ◽  
Vol 2008 (Spring) ◽  
Author(s):  
Silke Götze ◽  
Sonja Sievers ◽  
Oliver Müller
Keyword(s):  
Epigenetic Regulation ◽  
Wnt Signalling ◽  
Signalling Pathway ◽  
Wnt Signalling Pathway

Anticancer activity of peptide extracted from edible mushroom; Lentinus squarrosulus in human lung cancer cells

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
S Sumkhemthong ◽  
M Suksomtip ◽  
P Chanvorachote ◽  
C Chaotham
Keyword(s):  
Lung Cancer ◽  
Anticancer Activity ◽  
Cancer Cells ◽  
Human Lung ◽  
Edible Mushroom ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Human Lung Cancer Cells

Ras Denitrosylation in Human Lung Cancer

2012 ◽  
Vol 3 (2) ◽  
pp. 135-139
Author(s):  
Benjamin Gaston ◽  
Nadzeya Marozkina
Keyword(s):  
Lung Cancer ◽  
Human Lung ◽  
Human Lung Cancer

MicroRNAs expression signature in human lung cancer cell

2014 ◽  
Author(s):  
Geyu Liang ◽  
Xikai Wang ◽  
Yanqiu Zhang ◽  
Yanyun Fu ◽  
Lihong Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Cell ◽  
Human Lung ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Human Lung Cancer Cell ◽  
Expression Signature

Inhibitory effects of Actinidia Chinensis planch root extracts (acRoots) on human lung cancer cells through retinoic acid receptor beta

2017 ◽  
Vol 5 (1) ◽  
Author(s):  
Lingyan Wang ◽  
Jiayun Hou ◽  
Minghuan Zheng ◽  
Lin Shi
Keyword(s):  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Retinoic Acid Receptor ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Inhibitory Effects ◽  
The Core ◽  
Human Lung Cancer Cells ◽  
Receptor Beta

Actinidia Chinensis Planch roots (acRoots) are used to treat many cancers, although the anti-tumor mechanism by which acRoots inhibit cancer cell growth remains unclear. The present study aims at investigating inhibitory effects of acRoots on human lung cancer cells and potential mechanisms. Our data demonstrate that the inhibitory effects of acRoots on lung cancer cells depend on genetic backgrounds and phenotypes of cells. We furthermore found the expression of metabolism-associated gene profiles varied between acRoots-hypersensitive (H460) or hyposensitive lung cancer cells (H1299) after screening lung cancer cells with different genetic backgrounds. We selected retinoic acid receptor beta (RARB) as the core target within metabolism-associated core gene networks and evaluated RARB changes and roles in cells treated with acRoots at different concentrations and timeframes. Hypersensitive cancer cells with the deletion of RARB expression did not response to the treatment with acRoots, while RARB deletion did not change effects of acRoots on hyposensitive cells. Thus, it seems that RARB as the core target within metabolism-associated networks plays important roles in the regulation of lung cancer cell sensitivity to acRoots.

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