Effect of guava (Psidium guajavaLinn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats

2008 ◽  
Vol 22 (11) ◽  
pp. 1458-1464 ◽  
Author(s):  
Szu-Chuan Shen ◽  
Fang-Chi Cheng ◽  
Ning-Jung Wu
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Rats ◽  
Soluble Solids ◽  
Type 2 Diabetic

scholarly journals AVE8134, a novel potent PPARα agonist, improves lipid profile and glucose metabolism in dyslipidemic mice and type 2 diabetic rats

2012 ◽  
Vol 33 (1) ◽  
pp. 82-90 ◽  
Author(s):  
Hans Ludwig Schäfer ◽  
Wolfgang Linz ◽  
Eugen Falk ◽  
Maike Glien ◽  
Heiner Glombik ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Lipid Profile ◽  
Diabetic Rats ◽  
Type 2 Diabetic ◽  
Pparα Agonist

Zhenqing Recipe Improves Glucose Metabolism and Insulin Sensitivity by Repressing Hepatic FOXO1 in Type 2 Diabetic Rats

2012 ◽  
Vol 40 (04) ◽  
pp. 721-733 ◽  
Author(s):  
Wenfan Huang ◽  
Jie Yu ◽  
Xuming Jia ◽  
Liang Xiong ◽  
Ningxu Li ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Metabolism ◽  
Mrna Expression ◽  
Diabetic Rats ◽  
Control Group ◽  
Oral Glucose ◽  
Sensitivity Index ◽  
Mrna Levels ◽  
Type 2 Diabetic

Forkhead box O1 (FOXO1) plays an important role in glucose metabolism at the gene transcription level. Increased FOXO1 activity results in hyperglycemia by promoting the expression of gluconeogenic enzymes such as phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), and inhibiting glucokinase (GK). This study evaluates the effect of Zhenqing Recipe (ZQR), a Chinese herbal medicine, on hyperglycemia and its molecular mechanisms. Type 2 diabetic rats, developed by high-fat diet combined with low-dose STZ injections, were randomly divided into untreated diabetic, ZQR and metformin group. Normal rats served as control. After an eight-week treatment, fasting blood glucose was significantly decreased and insulin sensitivity index was obviously increased in the ZQR group. ZQR also improved the oral glucose tolerance. Compared with the control group, the mRNA levels of PEPCK and G6Pase were significantly elevated, while GK mRNA expression was decreased in the liver of untreated diabetic rats. ZQR significantly reduced the mRNA levels of PEPCK and G6Pase, and increased GK mRNA expression. The hepatic mRNA and protein expression of FOXO1 in the untreated diabetic group was markedly increased compared to controls. The administration of ZQR significantly decreased the mRNA and protein levels of hepatic FOXO1. The data suggest that ZQR improves glucose metabolism and insulin sensitivity, which is accompanied with regulating mRNA expression of GK and gluconeogenic genes. This anti-diabetic effect of ZQR is due to its ability to repress hepatic FOXO1 at the mRNA and protein level.

Central galanin receptor 2 mediates galanin action to promote systemic glucose metabolism of type 2 diabetic rats

2018 ◽  
Vol 156 ◽  
pp. 241-247 ◽  
Author(s):  
Penghua Fang ◽  
Biao He ◽  
Mei Yu ◽  
Mingyi Shi ◽  
Yan Zhu ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Diabetic Rats ◽  
Galanin Receptor ◽  
Type 2 Diabetic

scholarly journals Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats

2017 ◽  
Vol 54 (8) ◽  
pp. 2260-2269 ◽  
Author(s):  
CuiFeng Zhu ◽  
Wei Zhang ◽  
Bo Mu ◽  
Fan Zhang ◽  
NanNan Lai ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Glucose Metabolism ◽  
Diabetic Rats ◽  
Collagen Peptides ◽  
Type 2 Diabetic
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