Ultrasound‐Assisted Expeditious Catalyst‐Free Green Approach towards Diastereoselective Synthesis of Spiro[indoline‐3,2′‐pyrido[2,1‐
            b
            ][1,3]oxazine]‐3′,4′‐dicarboxylate Scaffolds

This review presents the detailed picture of current knowledge on ultrasound assisted chemical reactions and its green approach in chemical synthesis. This article illustrates the theoretical background and details about ultrasound, its mechanism (cavitation, the driving force) in chemical synthesis, types of reactions with different systems and its utility. All the reported applications have shown that Sonochemistry, ultrasound assisted chemical reaction is a green and economical viable approach for drug, impurity or chemical intermediate synthesis. Keywords: Cavitation, Sonocatalysis, Sonochemistry Ultrasound

Download Full-text

Ultrasound Assisted One-Pot Synthesis of Tetrahydropyrimidne Deriva-tives through Biginelli Condensation: A Catalyst Free Green Chemistry Approach

Letters in Organic Chemistry ◽

10.2174/1570178617999201105162851 ◽

2020 ◽

Vol 17 ◽

Author(s):

Ashish Patel ◽

Jinagna Shah ◽

Kesha Patel ◽

Krishna Patel ◽

Harit Patel ◽

...

Keyword(s):

Aromatic Aldehydes ◽

Green Technology ◽

Sustainable Chemistry ◽

Structural Variants ◽

One Pot ◽

The Past ◽

Catalyst Free ◽

Classical Methodology ◽

Ultrasound Assisted ◽

Biginelli Condensation

: The chemical applications of ultrasound, "sonochemistry", has become an exciting new field of research during the past decade as it can increase reactivities by nearly a million fold. Owing to the increasing use of Green technology approach, due to its various merits over Classical methodology and as a need for sustainable Chemistry, this reaction has received renewed interest for preparing tetrahydropyrimidine (THPM) through Biginelii condensation in an environmentally thoughtful manner with improved yields. The classical reaction has been modified in the recent past with/without various catalysts and several structural variants in different solvents to synthesize a large number of Biginelli type compounds due to its diverse pharmacological properties. We reported ultrasound assisted one-pot catalyst free procedure for the synthesis of 6-Aryl substituted-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-Carbonitrile from various aromatic aldehydes, ethyl cyano-acetate and urea under a basic condition with affording isolated yield up to 99% within a reaction time of 5-20 min under mild condition. The synthesized products were characterized by MP, IR, NMR and Mass spectroscopies.

Download Full-text

A pot-economical and diastereoselective synthesis involving catalyst-free click reaction for fused-triazolobenzodiazepines

Green Chemistry ◽

10.1039/c6gc00497k ◽

2016 ◽

Vol 18 (9) ◽

pp. 2642-2646 ◽

Cited By ~ 35

Author(s):

Xiaofeng Zhang ◽

Sanjun Zhi ◽

Wei Wang ◽

Shuai Liu ◽

Jerry P. Jasinski ◽

...

Keyword(s):

Click Reaction ◽

Diastereoselective Synthesis ◽

Polycyclic Compounds ◽

Catalyst Free

A pot-economical synthesis involving two [3 + 2] cycloadditions for diastereoselective synthesis of novel triazolobenzodiazepine-containing polycyclic compounds.

Download Full-text

An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes

Chemical Communications ◽

10.1039/c8cc00180d ◽

2018 ◽

Vol 54 (23) ◽

pp. 2870-2873 ◽

Cited By ~ 16

Author(s):

Bo Cao ◽

Yin Wei ◽

Min Shi

Keyword(s):

Indole Derivatives ◽

Diastereoselective Synthesis ◽

Free Atmosphere ◽

Catalyst Free ◽

Wide Range

A catalyst-free atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes and alkynes was developed, which provided a wide range of cyclobuta- and cyclopenta[b]indole derivatives in good yields.

Download Full-text