Design, Synthesis and In Vivo Cardiovascular Evaluation of Some Novel Aryloxy Propanol Amino Acid Derivatives

2021 ◽  
Vol 6 (47) ◽  
pp. 13595-13600
Author(s):  
Ava Soltani Hekmat ◽  
Mojtaba Farjam ◽  
Kazem Javanmardi ◽  
Somayeh Behrouz ◽  
Elham Zarenezhad ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Cardiovascular Evaluation

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

Design, Synthesis, and SAR of Amino Acid Derivatives as Factor Xa Inhibitors

2001 ◽  
Vol 11 (22) ◽  
pp. 2947-2950 ◽  
Author(s):  
Ting Su ◽  
Yanhong Wu ◽  
Brandon Doughan ◽  
Zhaozhong J. Jia ◽  
John Woolfrey ◽  
...  
Keyword(s):  
Amino Acid ◽  
Factor Xa ◽  
Factor Xa Inhibitors ◽  
Amino Acid Derivatives ◽  
Design Synthesis

scholarly journals Research in vivo the qualities of potential antitumor amino-acid derivatives of glycosides of indolocarbazol

2017 ◽  
Vol 16 (4) ◽  
pp. 85-92 ◽  
Author(s):  
I. S. Golubeva ◽  
N. P. Yavorskaya ◽  
O. V. Goryunova
Keyword(s):  
Amino Acid ◽  
Antitumor Activity ◽  
Optimal Dose ◽  
Amino Acid Derivatives ◽  
Tumor Growth Inhibition ◽  
Active Metabolites ◽  
Derivatives Of ◽  
Potential Antitumor

Background. The addition of active metabolites (in particular, amino acids) to the molecule affects the physicochemical and prodrug properties of derivatives of indolocarbazoles. Using computed chemoinformatics, probability antitumor activity of amino-acid derivatives of glycosides of indolocarbazol (AADGI) is predicted with low probability of their cytotoxic activity in vitro. Based on these data, a study of these compounds in vivo is conducted. Objective: the assessment of AADGI as potential antitumor medications. Materials and methods. Research antitumor activity of AADGI was done using murine tumor models - cervical cancer CC-5. Investigated compounds were injected to mice СВА abdominally 5-times daily with interval of 24 h. Observation of animals were continued till their death. Antitumor effect of compounds was assessed by criteria of tumor growth inhibition and increase in life expectancy of mice comparing to control animals. Results. The optimal dose for these series of compounds was titrated and this dose is 100 mg/kg. Antitumor activity of AADGI was assessed on CC-5. Conclusions. Based on data received we suggest an extended study in vivo of antitumor qualities of selected 5 leader AADGI.

scholarly journals Amino Acid Derivatives as Palmitoylethanolamide Prodrugs: Synthesis, In Vitro Metabolism and In Vivo Plasma Profile in Rats

PLoS ONE ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. e0128699 ◽  
Author(s):  
Federica Vacondio ◽  
Michele Bassi ◽  
Claudia Silva ◽  
Riccardo Castelli ◽  
Caterina Carmi ◽  
...  
Keyword(s):  
Amino Acid ◽  
In Vitro Metabolism ◽  
Amino Acid Derivatives ◽  
Plasma Profile
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